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Bladder Granular Cell Tumor

MedGen UID:
1704182
•Concept ID:
C5204621
•
Neoplastic Process

Definition

A rare granular cell tumor arising from the bladder. Most tumors are benign. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Granular Cell Tumor

Recent clinical studies

Etiology

Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
Lee C, Kim B, Song B, Park JH, Moon KC
Int J Surg Pathol 2018 May;26(3):221-228. Epub 2017 Nov 26 doi: 10.1177/1066896917742722. PMID: 29172920
Granular Cell Tumor of the Bladder: A Rare Neoplasm Managed With Robotic Partial Cystectomy Using Near-infrared Filter Guidance.
Yarlagadda VK, Benson DG, Gordetsky JB, Rais-Bahrami S
Urology 2017 May;103:7-11. Epub 2016 Nov 25 doi: 10.1016/j.urology.2016.11.024. PMID: 27894977
Granular cell tumors of the urinary bladder.
Abbas F, Memon A, Siddiqui T, Kayani N, Ahmad NA
World J Surg Oncol 2007 Mar 13;5:33. doi: 10.1186/1477-7819-5-33. PMID: 17355632Free PMC Article
Small cell neuroendocrine carcinoma of the urinary bladder. A clinicopathologic study with emphasis on cytologic features.
Ali SZ, Reuter VE, Zakowski MF
Cancer 1997 Jan 15;79(2):356-61. doi: 10.1002/(sici)1097-0142(19970115)79:2<356::aid-cncr19>3.0.co;2-#. PMID: 9010109

Diagnosis

Perivascular Epithelioid Cell Tumor of Urinary Bladder.
Wu YL, Lang L, Ma Q, Wu F, Zhang Y, Chen W, Yan XC, Duan GJ
Am J Clin Pathol 2021 Jun 17;156(1):56-71. doi: 10.1093/ajcp/aqaa204. PMID: 33336255
Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
Lee C, Kim B, Song B, Park JH, Moon KC
Int J Surg Pathol 2018 May;26(3):221-228. Epub 2017 Nov 26 doi: 10.1177/1066896917742722. PMID: 29172920
Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature.
Knez VM, Barrow W, Lucia MS, Wilson S, La Rosa FG
J Med Case Rep 2014 Aug 14;8:275. doi: 10.1186/1752-1947-8-275. PMID: 25124389Free PMC Article
Perineurial cells in granular cell tumors and neoplasms with perineural invasion: an immunohistochemical study.
Izquierdo F, Suárez-Vilela D, Honrado E
Am J Dermatopathol 2012 Dec;34(8):800-9. doi: 10.1097/DAD.0b013e31824ba93b. PMID: 22668577

Therapy

Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer.
Hammam OA, Aziz AA, Roshdy MS, Abdel Hadi AM
Medscape J Med 2008 Mar 11;10(3):60. PMID: 18449376Free PMC Article
Ultrastructural analysis of nucleolar transcription in cells microinjected with 5-bromo-UTP.
Cmarko D, Verschure PJ, Rothblum LI, Hernandez-Verdun D, Amalric F, van Driel R, Fakan S
Histochem Cell Biol 2000 Mar;113(3):181-7. doi: 10.1007/s004180050437. PMID: 10817672
Determination and reversal of resistance to epirubicin intravesical chemotherapy. A confocal imaging study.
Duffy PM, Hayes MC, Gatrell SK, Cooper A, Smart CJ
Br J Urol 1996 Jun;77(6):824-9. doi: 10.1046/j.1464-410x.1996.09539.x. PMID: 8705215
Activation by the protein-bound polysaccharide PSK (krestin) of cytotoxic lymphocytes that act on fresh autologous tumor cells and T24 human urinary bladder transitional carcinoma cell line in patients with urinary bladder cancer.
Mizutani Y, Yoshida O
J Urol 1991 May;145(5):1082-7. doi: 10.1016/s0022-5347(17)38539-7. PMID: 2016797

Prognosis

Perivascular Epithelioid Cell Tumor of Urinary Bladder.
Wu YL, Lang L, Ma Q, Wu F, Zhang Y, Chen W, Yan XC, Duan GJ
Am J Clin Pathol 2021 Jun 17;156(1):56-71. doi: 10.1093/ajcp/aqaa204. PMID: 33336255
Granular Cell Tumor of the Bladder: A Report of Six Cases.
Sun Y, Reuter VE, Magi-Galluzzi C, Sankin A, Epstein JI
Urology 2018 Nov;121:203.e1-203.e5. Epub 2018 Aug 29 doi: 10.1016/j.urology.2018.08.018. PMID: 30170086Free PMC Article
Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
Lee C, Kim B, Song B, Park JH, Moon KC
Int J Surg Pathol 2018 May;26(3):221-228. Epub 2017 Nov 26 doi: 10.1177/1066896917742722. PMID: 29172920
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma.
Eandi JA, Asuncion A, Vandewalker KN, Javidan J
Int J Urol 2007 Sep;14(9):862-4. doi: 10.1111/j.1442-2042.2007.01827.x. PMID: 17760758
Small cell neuroendocrine carcinoma with skeletal muscle differentiation: report of three cases.
Eusebi V, Damiani S, Pasquinelli G, Lorenzini P, Reuter VE, Rosai J
Am J Surg Pathol 2000 Feb;24(2):223-30. doi: 10.1097/00000478-200002000-00008. PMID: 10680890

Clinical prediction guides

Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature.
Knez VM, Barrow W, Lucia MS, Wilson S, La Rosa FG
J Med Case Rep 2014 Aug 14;8:275. doi: 10.1186/1752-1947-8-275. PMID: 25124389Free PMC Article
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma.
Eandi JA, Asuncion A, Vandewalker KN, Javidan J
Int J Urol 2007 Sep;14(9):862-4. doi: 10.1111/j.1442-2042.2007.01827.x. PMID: 17760758
Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm.
Pan CC, Jong YJ, Chai CY, Huang SH, Chen YJ
Hum Pathol 2006 May;37(5):606-12. doi: 10.1016/j.humpath.2006.01.008. PMID: 16647959
Immunohistochemical localization of hTERT protein in human tissues.
Yan P, Benhattar J, Seelentag W, Stehle JC, Bosman FT
Histochem Cell Biol 2004 May;121(5):391-7. Epub 2004 May 7 doi: 10.1007/s00418-004-0645-5. PMID: 15138842
Diagnostic utility of renal cell carcinoma marker in cytopathology.
Gokden N, Mukunyadzi P, James JD, Gokden M
Appl Immunohistochem Mol Morphol 2003 Jun;11(2):116-9. doi: 10.1097/00129039-200306000-00004. PMID: 12777993

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