U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Pancreatic Adenocarcinoma

MedGen UID:
1704860
Concept ID:
C5206249
Neoplastic Process

Definition

Pancreatic adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Pancreatic Adenocarcinoma

Recent clinical studies

Etiology

Hines OJ, Pandol SJ
BMJ 2024 Feb 26;384:e070920. doi: 10.1136/bmj-2023-070920. PMID: 38408777
Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Vouros D, Bramis K, Alexakis N, Kotsarinis V, Antonakis P, Memos N, Konstadoulakis M, Toutouzas K
Am Surg 2023 Dec;89(12):6134-6146. Epub 2023 Jun 9 doi: 10.1177/00031348231183121. PMID: 37295804
Dev R, Fortuno ES 3rd, Amaram-Davila JS, Haider A, Bruera E
Ann Palliat Med 2023 May;12(3):600-606. Epub 2023 Mar 14 doi: 10.21037/apm-22-1167. PMID: 37038067
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141

Diagnosis

Hines OJ, Pandol SJ
BMJ 2024 Feb 26;384:e070920. doi: 10.1136/bmj-2023-070920. PMID: 38408777
Sato H, Sasaki K, Hara T, Tsuji Y, Arao Y, Otsuka C, Hamano Y, Ogita M, Kobayashi S, di Luccio E, Hirotsu T, Doki Y, Eguchi H, Satoh T, Uchida S, Ishii H
Biomolecules 2022 Oct 17;12(10) doi: 10.3390/biom12101503. PMID: 36291712Free PMC Article
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article

Therapy

Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Bardia A, Messersmith WA, Kio EA, Berlin JD, Vahdat L, Masters GA, Moroose R, Santin AD, Kalinsky K, Picozzi V, O'Shaughnessy J, Gray JE, Komiya T, Lang JM, Chang JC, Starodub A, Goldenberg DM, Sharkey RM, Maliakal P, Hong Q, Wegener WA, Goswami T, Ocean AJ
Ann Oncol 2021 Jun;32(6):746-756. Epub 2021 Mar 16 doi: 10.1016/j.annonc.2021.03.005. PMID: 33741442
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article
Morello A, Sadelain M, Adusumilli PS
Cancer Discov 2016 Feb;6(2):133-46. Epub 2015 Oct 26 doi: 10.1158/2159-8290.CD-15-0583. PMID: 26503962Free PMC Article

Prognosis

Yamamoto Y, Kasashima H, Fukui Y, Tsujio G, Yashiro M, Maeda K
Cancer Sci 2023 Jan;114(1):16-24. Epub 2022 Oct 19 doi: 10.1111/cas.15609. PMID: 36197901Free PMC Article
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ
Cancer Discov 2021 Mar;11(3):736-753. Epub 2020 Nov 6 doi: 10.1158/2159-8290.CD-20-0519. PMID: 33158848Free PMC Article

Clinical prediction guides

Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Zhang Y, Liu Q, Cui M, Wang M, Hua S, Gao J, Liao Q
Front Immunol 2021;12:774435. Epub 2022 Jan 3 doi: 10.3389/fimmu.2021.774435. PMID: 35046938Free PMC Article
Lin J, Cao Y, Yang X, Li G, Shi Y, Wang D, Long J, Song Y, Mao J, Xie F, Bai Y, Zhang L, Yang X, Wan X, Wang A, Guan M, Zhao L, Hu K, Pan J, Huo L, Lu X, Mao Y, Sang X, Zhang H, Wang K, Wang X, Zhao H
Theranostics 2021;11(10):4585-4598. Epub 2021 Mar 4 doi: 10.7150/thno.56539. PMID: 33754015Free PMC Article
Liudahl SM, Betts CB, Sivagnanam S, Morales-Oyarvide V, da Silva A, Yuan C, Hwang S, Grossblatt-Wait A, Leis KR, Larson W, Lavoie MB, Robinson P, Dias Costa A, Väyrynen SA, Clancy TE, Rubinson DA, Link J, Keith D, Horton W, Tempero MA, Vonderheide RH, Jaffee EM, Sheppard B, Goecks J, Sears RC, Park BS, Mori M, Nowak JA, Wolpin BM, Coussens LM
Cancer Discov 2021 Aug;11(8):2014-2031. Epub 2021 Mar 16 doi: 10.1158/2159-8290.CD-20-0841. PMID: 33727309Free PMC Article

Recent systematic reviews

Vouros D, Bramis K, Alexakis N, Kotsarinis V, Antonakis P, Memos N, Konstadoulakis M, Toutouzas K
Am Surg 2023 Dec;89(12):6134-6146. Epub 2023 Jun 9 doi: 10.1177/00031348231183121. PMID: 37295804
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...