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Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

MedGen UID:
1705089
Concept ID:
C5203866
Neoplastic Process

Definition

A prostate adenocarcinoma characterized by the presence of cells with eosinophilic cytoplasmic granules that are positive for neuroendocrine markers by immunohistochemistry. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

Professional guidelines

PubMed

Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087

Recent clinical studies

Etiology

Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Salles DC, Mata DA, Epstein JI
Hum Pathol 2020 Aug;102:7-12. Epub 2020 May 20 doi: 10.1016/j.humpath.2020.05.003. PMID: 32445653
Park K, Chen Z, MacDonald TY, Siddiqui J, Ye H, Erbersdobler A, Shevchuk MM, Robinson BD, Sanda MG, Chinnaiyan AM, Beltran H, Rubin MA, Mosquera JM
Hum Pathol 2014 Oct;45(10):2136-43. Epub 2014 Jun 26 doi: 10.1016/j.humpath.2014.06.008. PMID: 25128228Free PMC Article
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969
Adlakha H, Bostwick DG
Hum Pathol 1994 Feb;25(2):135-9. doi: 10.1016/0046-8177(94)90268-2. PMID: 7509774

Diagnosis

Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Galea LA, Mow C, Fine SW, Manohar P
Int J Surg Pathol 2022 Apr;30(2):232-236. Epub 2021 Aug 2 doi: 10.1177/10668969211035844. PMID: 34338584Free PMC Article
So JS, Gordetsky J, Epstein JI
Hum Pathol 2014 Dec;45(12):2388-93. Epub 2014 Aug 23 doi: 10.1016/j.humpath.2014.08.004. PMID: 25277321
Chen YB, Epstein JI
Am J Surg Pathol 2011 Mar;35(3):442-6. doi: 10.1097/PAS.0b013e318208f96a. PMID: 21317716
Lee TK, Miller JS, Epstein JI
Pathology 2010 Jun;42(4):319-24. doi: 10.3109/00313021003767314. PMID: 20438402

Therapy

Galea LA, Mow C, Fine SW, Manohar P
Int J Surg Pathol 2022 Apr;30(2):232-236. Epub 2021 Aug 2 doi: 10.1177/10668969211035844. PMID: 34338584Free PMC Article
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969

Prognosis

Gopalan A, Al-Ahmadie H, Chen YB, Sarungbam J, Sirintrapun SJ, Tickoo SK, Reuter VE, Fine SW
Histopathology 2022 Aug;81(2):246-254. Epub 2022 Jul 11 doi: 10.1111/his.14707. PMID: 35758203Free PMC Article
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Salles DC, Mata DA, Epstein JI
Hum Pathol 2020 Aug;102:7-12. Epub 2020 May 20 doi: 10.1016/j.humpath.2020.05.003. PMID: 32445653
So JS, Gordetsky J, Epstein JI
Hum Pathol 2014 Dec;45(12):2388-93. Epub 2014 Aug 23 doi: 10.1016/j.humpath.2014.08.004. PMID: 25277321
Park K, Chen Z, MacDonald TY, Siddiqui J, Ye H, Erbersdobler A, Shevchuk MM, Robinson BD, Sanda MG, Chinnaiyan AM, Beltran H, Rubin MA, Mosquera JM
Hum Pathol 2014 Oct;45(10):2136-43. Epub 2014 Jun 26 doi: 10.1016/j.humpath.2014.06.008. PMID: 25128228Free PMC Article

Clinical prediction guides

Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
So JS, Gordetsky J, Epstein JI
Hum Pathol 2014 Dec;45(12):2388-93. Epub 2014 Aug 23 doi: 10.1016/j.humpath.2014.08.004. PMID: 25277321
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969
Weaver MG, Abdul-Karim FW, Srigley J, Bostwick DG, Ro JY, Ayala AG
Am J Surg Pathol 1992 Jan;16(1):62-8. doi: 10.1097/00000478-199201000-00009. PMID: 1370193

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