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CBFB Gene Rearrangement

MedGen UID:
1705104
Concept ID:
C5204022
Cell or Molecular Dysfunction
Synonyms: CBF-Beta Gene Rearrangement; CBFB Rearrangement; Core-Binding Factor Subunit Beta Gene Rearrangement; PEBP2B Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the CBFB gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCBFB Gene Rearrangement

Professional guidelines

PubMed

Saal RJ, Marlton PV, Timson G, Gill DS, Waugh M, Springall F, Iland H
Pathology 2004 Aug;36(4):335-42. doi: 10.1080/0031302042000224593. PMID: 15370133

Recent clinical studies

Etiology

Mansoor N, Javed O, Rafiq N, Aali A, Meraj F
J Hematop 2023 Mar;16(1):49-55. Epub 2023 Mar 1 doi: 10.1007/s12308-023-00535-w. PMID: 38175376
Assaf N, Lefebvre C, Raggueneau V, Guignedoux G, Marceau-Renaut A, Chevalier S, Tondeur S, Bories D, Benramdane R, Rousselot P, Terré C
Hematology 2022 Dec;27(1):636-641. doi: 10.1080/16078454.2022.2078027. PMID: 35622005
Matthijssens F, Sharma ND, Nysus M, Nickl CK, Kang H, Perez DR, Lintermans B, Van Loocke W, Roels J, Peirs S, Demoen L, Pieters T, Reunes L, Lammens T, De Moerloose B, Van Nieuwerburgh F, Deforce DL, Cheung LC, Kotecha RS, Risseeuw MD, Van Calenbergh S, Takarada T, Yoneda Y, van Delft FW, Lock RB, Merkley SD, Chigaev A, Sklar LA, Mullighan CG, Loh ML, Winter SS, Hunger SP, Goossens S, Castillo EF, Ornatowski W, Van Vlierberghe P, Matlawska-Wasowska K
J Clin Invest 2021 Mar 15;131(6) doi: 10.1172/JCI141566. PMID: 33555272Free PMC Article
Hara Y, Shiba N, Yamato G, Ohki K, Tabuchi K, Sotomatsu M, Tomizawa D, Kinoshita A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, Hayashi Y
Br J Haematol 2020 Feb;188(4):528-539. Epub 2019 Oct 14 doi: 10.1111/bjh.16203. PMID: 31612466
Langabeer SE, Grimwade D, Walker H, Rogers JR, Burnett AK, Goldstone AH, Linch DC
Br J Haematol 1998 May;101(2):338-40. doi: 10.1046/j.1365-2141.1998.00686.x. PMID: 9609531

Diagnosis

Mansoor N, Javed O, Rafiq N, Aali A, Meraj F
J Hematop 2023 Mar;16(1):49-55. Epub 2023 Mar 1 doi: 10.1007/s12308-023-00535-w. PMID: 38175376
Assaf N, Lefebvre C, Raggueneau V, Guignedoux G, Marceau-Renaut A, Chevalier S, Tondeur S, Bories D, Benramdane R, Rousselot P, Terré C
Hematology 2022 Dec;27(1):636-641. doi: 10.1080/16078454.2022.2078027. PMID: 35622005
Dembitz V, Lalic H, Tomic B, Smoljo T, Batinic J, Dubravcic K, Batinic D, Bedalov A, Visnjic D
Int J Hematol 2022 Jan;115(1):43-53. Epub 2021 Sep 21 doi: 10.1007/s12185-021-03224-5. PMID: 34546543
Khalil SH
Saudi Med J 2005 Oct;26(10):1516-22. PMID: 16228048
Boeckx N, Willemse MJ, Szczepanski T, van der Velden VH, Langerak AW, Vandekerckhove P, van Dongen JJ
Leukemia 2002 Mar;16(3):368-75. doi: 10.1038/sj.leu.2402387. PMID: 11896540

Therapy

Yang X, Liu Q, Zhang R, Yang X, Wang L, Zhang Z, Li Y, Lin L
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):865-867. doi: 10.4103/ijpm.ijpm_415_22. PMID: 38084551
Dembitz V, Lalic H, Tomic B, Smoljo T, Batinic J, Dubravcic K, Batinic D, Bedalov A, Visnjic D
Int J Hematol 2022 Jan;115(1):43-53. Epub 2021 Sep 21 doi: 10.1007/s12185-021-03224-5. PMID: 34546543
Thys RG, Lehman CE, Pierce LC, Wang YH
Mutat Res 2015 Sep;779:86-95. Epub 2015 Jun 27 doi: 10.1016/j.mrfmmm.2015.06.011. PMID: 26163765Free PMC Article
Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA
Blood 2013 Sep 5;122(10):1761-9. Epub 2013 Jul 22 doi: 10.1182/blood-2013-01-476473. PMID: 23878140
Dissing M, Le Beau MM, Pedersen-Bjergaard J
J Clin Oncol 1998 May;16(5):1890-6. doi: 10.1200/JCO.1998.16.5.1890. PMID: 9586906

Prognosis

Mansoor N, Javed O, Rafiq N, Aali A, Meraj F
J Hematop 2023 Mar;16(1):49-55. Epub 2023 Mar 1 doi: 10.1007/s12308-023-00535-w. PMID: 38175376
Assaf N, Lefebvre C, Raggueneau V, Guignedoux G, Marceau-Renaut A, Chevalier S, Tondeur S, Bories D, Benramdane R, Rousselot P, Terré C
Hematology 2022 Dec;27(1):636-641. doi: 10.1080/16078454.2022.2078027. PMID: 35622005
Kim T, Moon JH, Ahn JS, Ahn SY, Jung SH, Yang DH, Lee JJ, Shin MG, Choi SH, Lee JY, Tyndel MS, Lee HY, Kim KH, Cai Y, Lee YJ, Sohn SK, Min YH, Cheong JW, Kim HJ, Zhang Z, Kim DDH
Sci Rep 2020 Nov 18;10(1):20119. doi: 10.1038/s41598-020-76933-2. PMID: 33208771Free PMC Article
Metzeler KH, Bloomfield CD
Adv Exp Med Biol 2017;962:175-199. doi: 10.1007/978-981-10-3233-2_12. PMID: 28299658
Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA
Blood 2013 Sep 5;122(10):1761-9. Epub 2013 Jul 22 doi: 10.1182/blood-2013-01-476473. PMID: 23878140

Clinical prediction guides

Dembitz V, Lalic H, Tomic B, Smoljo T, Batinic J, Dubravcic K, Batinic D, Bedalov A, Visnjic D
Int J Hematol 2022 Jan;115(1):43-53. Epub 2021 Sep 21 doi: 10.1007/s12185-021-03224-5. PMID: 34546543
Thys RG, Lehman CE, Pierce LC, Wang YH
Mutat Res 2015 Sep;779:86-95. Epub 2015 Jun 27 doi: 10.1016/j.mrfmmm.2015.06.011. PMID: 26163765Free PMC Article
Park TS, Lee ST, Song J, Lee KA, Lee JH, Kim J, Lee HJ, Han JH, Kim JK, Cho SR, Choi JR
Cancer Genet Cytogenet 2009 Mar;189(2):87-92. doi: 10.1016/j.cancergencyto.2008.10.012. PMID: 19215788
Cascavilla N, Melillo L, D'Arena G, Greco MM, Carella AM, Sajeva MR, Perla G, Matera R, Minervini MM, Carotenuto M
Leuk Lymphoma 2000 Mar;37(1-2):105-13. doi: 10.3109/10428190009057633. PMID: 10721774
Dissing M, Le Beau MM, Pedersen-Bjergaard J
J Clin Oncol 1998 May;16(5):1890-6. doi: 10.1200/JCO.1998.16.5.1890. PMID: 9586906

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