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Increased peripheral blast count

MedGen UID:
1705169
•Concept ID:
C5139302
•
Finding
Synonyms: Elevated blast count; Elevated circulating blasts; Increased peripheral myeloblast count
 
HPO: HP:0032372

Definition

An increased count in the peripheral blood of cells that are precursors to mature circulating blood cells such as neutrophiles, monocytes, lymphocutes, and erythrocytes. Blasts are not usually found in significant numbers in the peripheral blood circulation, but can be observed in hematopoietic neoplasms such as leukemia, severe infections, and as a result of certain medications. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased peripheral blast count

Professional guidelines

PubMed

Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888
Signal transduction inhibitors in treatment of myelodysplastic syndromes.
Bachegowda L, Gligich O, Mantzaris I, Schinke C, Wyville D, Carrillo T, Braunschweig I, Steidl U, Verma A
J Hematol Oncol 2013 Jul 10;6:50. doi: 10.1186/1756-8722-6-50. PMID: 23841999Free PMC Article
ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse?
Thakar MS, Forman SJ
Hematology Am Soc Hematol Educ Program 2009:414-8. doi: 10.1182/asheducation-2009.1.414. PMID: 20008227

Recent clinical studies

Etiology

Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome.
Carlsten M, Baumann BC, Simonsson M, Jädersten M, Forsblom AM, Hammarstedt C, Bryceson YT, Ljunggren HG, Hellström-Lindberg E, Malmberg KJ
Leukemia 2010 Sep;24(9):1607-16. Epub 2010 Jul 8 doi: 10.1038/leu.2010.149. PMID: 20613786
Transient leukemia in newborns with Down syndrome.
Massey GV
Pediatr Blood Cancer 2005 Jan;44(1):29-32. doi: 10.1002/pbc.20141. PMID: 15558701
Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Hoelzer D, Gökbuget N, Ottmann OG
Semin Hematol 2002 Oct;39(4 Suppl 3):32-7. doi: 10.1053/shem.2002.36927. PMID: 12447850
Prognostic factors in the myelodysplastic syndromes.
Tricot GJ
Leuk Res 1992;16(1):109-15. doi: 10.1016/0145-2126(92)90109-k. PMID: 1732663

Diagnosis

Peripheral Blasts in a Patient Receiving Chemotherapy.
Kshattry S, Parker TL, Huntington SF
JAMA 2023 Oct 24;330(16):1581-1582. doi: 10.1001/jama.2023.17117. PMID: 37801303
Interference of blast cell fragments with automated platelet counting.
Frotscher B, Salignac S, Muller M, Latger-Cannard V, Feugier P, Lesesve JF
Int J Lab Hematol 2015 Oct;37(5):613-9. Epub 2015 Apr 28 doi: 10.1111/ijlh.12371. PMID: 25923507
Leukocytosis.
Chabot-Richards DS, George TI
Int J Lab Hematol 2014 Jun;36(3):279-88. doi: 10.1111/ijlh.12212. PMID: 24750674
Prognostic factors in the myelodysplastic syndromes.
Tricot GJ
Leuk Res 1992;16(1):109-15. doi: 10.1016/0145-2126(92)90109-k. PMID: 1732663
The myelodysplastic syndrome: analysis of laboratory characteristics in relation to the FAB classification.
May SJ, Smith SA, Jacobs A, Williams A, Bailey-Wood R
Br J Haematol 1985 Feb;59(2):311-9. doi: 10.1111/j.1365-2141.1985.tb02996.x. PMID: 3970859

Therapy

Peripheral Blasts in a Patient Receiving Chemotherapy.
Kshattry S, Parker TL, Huntington SF
JAMA 2023 Oct 24;330(16):1581-1582. doi: 10.1001/jama.2023.17117. PMID: 37801303
Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse?
Thakar MS, Forman SJ
Hematology Am Soc Hematol Educ Program 2009:414-8. doi: 10.1182/asheducation-2009.1.414. PMID: 20008227
Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Hoelzer D, Gökbuget N, Ottmann OG
Semin Hematol 2002 Oct;39(4 Suppl 3):32-7. doi: 10.1053/shem.2002.36927. PMID: 12447850
Blast transformation in vivo and in vitro in carbamazepin hypersensitivity.
Virolainen M
Clin Exp Immunol 1971 Sep;9(3):429-35. PMID: 5571058Free PMC Article

Prognosis

Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Expansion of effector memory regulatory T cells represents a novel prognostic factor in lower risk myelodysplastic syndrome.
Mailloux AW, Sugimori C, Komrokji RS, Yang L, Maciejewski JP, Sekeres MA, Paquette R, Loughran TP Jr, List AF, Epling-Burnette PK
J Immunol 2012 Sep 15;189(6):3198-208. Epub 2012 Aug 8 doi: 10.4049/jimmunol.1200602. PMID: 22875800Free PMC Article
Transient leukemia in newborns with Down syndrome.
Massey GV
Pediatr Blood Cancer 2005 Jan;44(1):29-32. doi: 10.1002/pbc.20141. PMID: 15558701
Patterns of failure with increasing intensification of induction chemotherapy for acute myeloid leukaemia.
Matthews JP, Bishop JF, Young GA, Juneja SK, Lowenthal RM, Garson OM, Cobcroft RG, Dodds AJ, Enno A, Gillett EA, Hermann RP, Joshua DE, Ma DD, Szer J, Taylor KM, Wolf M, Bradstock KF; Australian Leukemia Study Group
Br J Haematol 2001 Jun;113(3):727-36. doi: 10.1046/j.1365-2141.2001.02756.x. PMID: 11380464
Prognostic factors in the myelodysplastic syndromes.
Tricot GJ
Leuk Res 1992;16(1):109-15. doi: 10.1016/0145-2126(92)90109-k. PMID: 1732663

Clinical prediction guides

Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Interference of blast cell fragments with automated platelet counting.
Frotscher B, Salignac S, Muller M, Latger-Cannard V, Feugier P, Lesesve JF
Int J Lab Hematol 2015 Oct;37(5):613-9. Epub 2015 Apr 28 doi: 10.1111/ijlh.12371. PMID: 25923507
A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia.
Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM, Kulkarni S, Abboud CN, Cashen AF, Stockerl-Goldstein KE, Vij R, Westervelt P, DiPersio JF
Blood 2012 Apr 26;119(17):3917-24. Epub 2012 Feb 2 doi: 10.1182/blood-2011-10-383406. PMID: 22308295Free PMC Article
Copper deficiency with increased hematogones mimicking refractory anemia with excess blasts.
Koca E, Buyukasik Y, Cetiner D, Yilmaz R, Sayinalp N, Yasavul U, Uner A
Leuk Res 2008 Mar;32(3):495-9. Epub 2007 Aug 13 doi: 10.1016/j.leukres.2007.06.023. PMID: 17706281
Prognostic factors in the myelodysplastic syndromes.
Tricot GJ
Leuk Res 1992;16(1):109-15. doi: 10.1016/0145-2126(92)90109-k. PMID: 1732663

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