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Advanced Lung Small Cell Carcinoma

MedGen UID:
1705311
Concept ID:
C5205119
Neoplastic Process

Definition

Small cell lung carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Lung Small Cell Carcinoma

Professional guidelines

PubMed

Terashima T, Morizane C, Hiraoka N, Tsuda H, Tamura T, Shimada Y, Kaneko S, Kushima R, Ueno H, Kondo S, Ikeda M, Okusaka T
Neuroendocrinology 2012;96(4):324-32. Epub 2012 Aug 28 doi: 10.1159/000338794. PMID: 22572060

Recent clinical studies

Etiology

Abbosh C, Frankell AM, Harrison T, Kisistok J, Garnett A, Johnson L, Veeriah S, Moreau M, Chesh A, Chaunzwa TL, Weiss J, Schroeder MR, Ward S, Grigoriadis K, Shahpurwalla A, Litchfield K, Puttick C, Biswas D, Karasaki T, Black JRM, Martínez-Ruiz C, Bakir MA, Pich O, Watkins TBK, Lim EL, Huebner A, Moore DA, Godin-Heymann N, L'Hernault A, Bye H, Odell A, Roberts P, Gomes F, Patel AJ, Manzano E, Hiley CT, Carey N, Riley J, Cook DE, Hodgson D, Stetson D, Barrett JC, Kortlever RM, Evan GI, Hackshaw A, Daber RD, Shaw JA, Aerts HJWL, Licon A, Stahl J, Jamal-Hanjani M; TRACERx Consortium, Birkbak NJ, McGranahan N, Swanton C
Nature 2023 Apr;616(7957):553-562. Epub 2023 Apr 13 doi: 10.1038/s41586-023-05776-4. PMID: 37055640Free PMC Article
de Scordilli M, Michelotti A, Bertoli E, De Carlo E, Del Conte A, Bearz A
Int J Mol Sci 2022 Jun 29;23(13) doi: 10.3390/ijms23137222. PMID: 35806230Free PMC Article
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C, Zhou Y
Mol Cancer 2021 Aug 20;20(1):105. doi: 10.1186/s12943-021-01398-4. PMID: 34416901Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article

Diagnosis

Megyesfalvi Z, Gay CM, Popper H, Pirker R, Ostoros G, Heeke S, Lang C, Hoetzenecker K, Schwendenwein A, Boettiger K, Bunn PA Jr, Renyi-Vamos F, Schelch K, Prosch H, Byers LA, Hirsch FR, Dome B
CA Cancer J Clin 2023 Nov-Dec;73(6):620-652. Epub 2023 Jun 17 doi: 10.3322/caac.21785. PMID: 37329269
Zhu Y, Cui Y, Zheng X, Zhao Y, Sun G
Biochim Biophys Acta Mol Basis Dis 2022 Dec 1;1868(12):166557. Epub 2022 Sep 24 doi: 10.1016/j.bbadis.2022.166557. PMID: 36162624
Yin X, Li Y, Wang H, Jia T, Wang E, Luo Y, Wei Y, Qin Z, Ma X
Semin Cancer Biol 2022 Nov;86(Pt 2):595-606. Epub 2022 Mar 8 doi: 10.1016/j.semcancer.2022.03.006. PMID: 35276343
Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS
Lancet 2021 Aug 7;398(10299):535-554. Epub 2021 Jul 21 doi: 10.1016/S0140-6736(21)00312-3. PMID: 34273294
Rudin CM, Brambilla E, Faivre-Finn C, Sage J
Nat Rev Dis Primers 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0. PMID: 33446664Free PMC Article

Therapy

Megyesfalvi Z, Gay CM, Popper H, Pirker R, Ostoros G, Heeke S, Lang C, Hoetzenecker K, Schwendenwein A, Boettiger K, Bunn PA Jr, Renyi-Vamos F, Schelch K, Prosch H, Byers LA, Hirsch FR, Dome B
CA Cancer J Clin 2023 Nov-Dec;73(6):620-652. Epub 2023 Jun 17 doi: 10.3322/caac.21785. PMID: 37329269
Abbosh C, Frankell AM, Harrison T, Kisistok J, Garnett A, Johnson L, Veeriah S, Moreau M, Chesh A, Chaunzwa TL, Weiss J, Schroeder MR, Ward S, Grigoriadis K, Shahpurwalla A, Litchfield K, Puttick C, Biswas D, Karasaki T, Black JRM, Martínez-Ruiz C, Bakir MA, Pich O, Watkins TBK, Lim EL, Huebner A, Moore DA, Godin-Heymann N, L'Hernault A, Bye H, Odell A, Roberts P, Gomes F, Patel AJ, Manzano E, Hiley CT, Carey N, Riley J, Cook DE, Hodgson D, Stetson D, Barrett JC, Kortlever RM, Evan GI, Hackshaw A, Daber RD, Shaw JA, Aerts HJWL, Licon A, Stahl J, Jamal-Hanjani M; TRACERx Consortium, Birkbak NJ, McGranahan N, Swanton C
Nature 2023 Apr;616(7957):553-562. Epub 2023 Apr 13 doi: 10.1038/s41586-023-05776-4. PMID: 37055640Free PMC Article
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Yin X, Li Y, Wang H, Jia T, Wang E, Luo Y, Wei Y, Qin Z, Ma X
Semin Cancer Biol 2022 Nov;86(Pt 2):595-606. Epub 2022 Mar 8 doi: 10.1016/j.semcancer.2022.03.006. PMID: 35276343
Bogart JA, Waqar SN, Mix MD
J Clin Oncol 2022 Feb 20;40(6):661-670. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01639. PMID: 34985935Free PMC Article

Prognosis

Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Zhu Y, Cui Y, Zheng X, Zhao Y, Sun G
Biochim Biophys Acta Mol Basis Dis 2022 Dec 1;1868(12):166557. Epub 2022 Sep 24 doi: 10.1016/j.bbadis.2022.166557. PMID: 36162624
Yin X, Li Y, Wang H, Jia T, Wang E, Luo Y, Wei Y, Qin Z, Ma X
Semin Cancer Biol 2022 Nov;86(Pt 2):595-606. Epub 2022 Mar 8 doi: 10.1016/j.semcancer.2022.03.006. PMID: 35276343
Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS
Lancet 2021 Aug 7;398(10299):535-554. Epub 2021 Jul 21 doi: 10.1016/S0140-6736(21)00312-3. PMID: 34273294
Rudin CM, Brambilla E, Faivre-Finn C, Sage J
Nat Rev Dis Primers 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0. PMID: 33446664Free PMC Article

Clinical prediction guides

Liu Q, Zhang J, Guo C, Wang M, Wang C, Yan Y, Sun L, Wang D, Zhang L, Yu H, Hou L, Wu C, Zhu Y, Jiang G, Zhu H, Zhou Y, Fang S, Zhang T, Hu L, Li J, Liu Y, Zhang H, Zhang B, Ding L, Robles AI, Rodriguez H, Gao D, Ji H, Zhou H, Zhang P
Cell 2024 Jan 4;187(1):184-203.e28. doi: 10.1016/j.cell.2023.12.004. PMID: 38181741
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Mamdani H, Matosevic S, Khalid AB, Durm G, Jalal SI
Front Immunol 2022;13:823618. Epub 2022 Feb 9 doi: 10.3389/fimmu.2022.823618. PMID: 35222404Free PMC Article
Bogart JA, Waqar SN, Mix MD
J Clin Oncol 2022 Feb 20;40(6):661-670. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01639. PMID: 34985935Free PMC Article
Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS
Lancet 2021 Aug 7;398(10299):535-554. Epub 2021 Jul 21 doi: 10.1016/S0140-6736(21)00312-3. PMID: 34273294

Recent systematic reviews

Rousseau A, Parisi C, Barlesi F
ESMO Open 2023 Apr;8(2):101184. Epub 2023 Mar 16 doi: 10.1016/j.esmoop.2023.101184. PMID: 36933320Free PMC Article
Cozma A, Sporis ND, Lazar AL, Buruiana A, Ganea AM, Malinescu TV, Berechet BM, Fodor A, Sitar-Taut AV, Vlad VC, Negrean V, Orasan OH
Int J Mol Sci 2022 Sep 19;23(18) doi: 10.3390/ijms231810948. PMID: 36142866Free PMC Article
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
John T, Taylor A, Wang H, Eichinger C, Freeman C, Ahn MJ
Cancer Epidemiol 2022 Feb;76:102080. Epub 2021 Dec 15 doi: 10.1016/j.canep.2021.102080. PMID: 34922050
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308

Supplemental Content

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    Practice guidelines

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