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Anal Canal Squamous Papilloma

MedGen UID:
1705646
•Concept ID:
C2019511
•
Neoplastic Process
Synonym: Anal Canal Squamous Cell Papilloma

Definition

A benign epithelial neoplasm that arises from the anal canal. It is characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Canal Squamous Papilloma

Professional guidelines

PubMed

Anal intraepithelial neoplasia: a review of terminology, differential diagnoses, and patient management.
Vyas M, Gonzalez RS
Hum Pathol 2023 Feb;132:56-64. Epub 2022 Jul 16 doi: 10.1016/j.humpath.2022.07.005. PMID: 35843339
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Optimal treatment strategies for anal cancer.
Ahmed S, Eng C
Curr Treat Options Oncol 2014 Sep;15(3):443-55. doi: 10.1007/s11864-014-0298-0. PMID: 25008956

Recent clinical studies

Etiology

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.
Wei F, Gaisa MM, D'Souza G, Xia N, Giuliano AR, Hawes SE, Gao L, Cheng SH, Donà MG, Goldstone SE, Schim van der Loeff MF, Neukam K, Meites E, Poynten IM, Dai J, Combes JD, Wieland U, Burgos J, Wilkin TJ, Hernandez AL, Iribarren Díaz M, Hidalgo-Tenorio C, Valencia Arredondo M, Nyitray AG, Wentzensen N, Chow EP, Smelov V, Nowak RG, Phanuphak N, Woo YL, Choi Y, Hu Y, Schofield AM, Woestenberg PJ, Chikandiwa AT, Hickey AC, de Pokomandy A, Murenzi G, Péré H, Del Pino M, Ortiz AP, Charnot-Katsikas A, Liu X, Chariyalertsak S, Strong C, Ong JJ, Yunihastuti E, Etienney I, Ferré VM, Zou H, Segondy M, Chinyowa S, Alberts CJ, Clifford GM
Lancet HIV 2021 Sep;8(9):e531-e543. Epub 2021 Jul 30 doi: 10.1016/S2352-3018(21)00108-9. PMID: 34339628Free PMC Article
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Anal Intraepithelial Neoplasia.
Limoges-Gonzalez M, Al-Juburi A
J Clin Gastroenterol 2017 Mar;51(3):203-207. doi: 10.1097/MCG.0000000000000721. PMID: 27749636

Diagnosis

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Pathology of Anal Cancer.
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
High-risk human papilloma virus, precancerous lesions and cancer in anal condylomas.
Albuquerque A, Cappello C, Stirrup O
AIDS 2021 Oct 1;35(12):1939-1948. doi: 10.1097/QAD.0000000000002975. PMID: 34101627
Therapeutic Vaccines Against Human Papilloma Viruses: Achievements and Prospects.
Vonsky MS, Runov AL, Gordeychuk IV, Isaguliants MG
Biochemistry (Mosc) 2019 Jul;84(7):800-816. doi: 10.1134/S0006297919070101. PMID: 31509730
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Investigational drugs for treating anal cancer and future perspectives.
Bustamante L, Frakes J, Hoffe S, Kim R
Expert Opin Investig Drugs 2016;25(1):51-62. Epub 2015 Dec 11 doi: 10.1517/13543784.2016.1116518. PMID: 26560877

Prognosis

Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.
Wei F, Gaisa MM, D'Souza G, Xia N, Giuliano AR, Hawes SE, Gao L, Cheng SH, Donà MG, Goldstone SE, Schim van der Loeff MF, Neukam K, Meites E, Poynten IM, Dai J, Combes JD, Wieland U, Burgos J, Wilkin TJ, Hernandez AL, Iribarren Díaz M, Hidalgo-Tenorio C, Valencia Arredondo M, Nyitray AG, Wentzensen N, Chow EP, Smelov V, Nowak RG, Phanuphak N, Woo YL, Choi Y, Hu Y, Schofield AM, Woestenberg PJ, Chikandiwa AT, Hickey AC, de Pokomandy A, Murenzi G, Péré H, Del Pino M, Ortiz AP, Charnot-Katsikas A, Liu X, Chariyalertsak S, Strong C, Ong JJ, Yunihastuti E, Etienney I, Ferré VM, Zou H, Segondy M, Chinyowa S, Alberts CJ, Clifford GM
Lancet HIV 2021 Sep;8(9):e531-e543. Epub 2021 Jul 30 doi: 10.1016/S2352-3018(21)00108-9. PMID: 34339628Free PMC Article
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Anal Neoplasia in Inflammatory Bowel Disease: Classification Proposal, Epidemiology, Carcinogenesis, and Risk Management Perspectives.
Wisniewski A, Fléjou JF, Siproudhis L, Abramowitz L, Svrcek M, Beaugerie L
J Crohns Colitis 2017 Aug 1;11(8):1011-1018. doi: 10.1093/ecco-jcc/jjx035. PMID: 28379306
Pathology of Anal Cancer.
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037

Clinical prediction guides

Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.
Wei F, Gaisa MM, D'Souza G, Xia N, Giuliano AR, Hawes SE, Gao L, Cheng SH, Donà MG, Goldstone SE, Schim van der Loeff MF, Neukam K, Meites E, Poynten IM, Dai J, Combes JD, Wieland U, Burgos J, Wilkin TJ, Hernandez AL, Iribarren Díaz M, Hidalgo-Tenorio C, Valencia Arredondo M, Nyitray AG, Wentzensen N, Chow EP, Smelov V, Nowak RG, Phanuphak N, Woo YL, Choi Y, Hu Y, Schofield AM, Woestenberg PJ, Chikandiwa AT, Hickey AC, de Pokomandy A, Murenzi G, Péré H, Del Pino M, Ortiz AP, Charnot-Katsikas A, Liu X, Chariyalertsak S, Strong C, Ong JJ, Yunihastuti E, Etienney I, Ferré VM, Zou H, Segondy M, Chinyowa S, Alberts CJ, Clifford GM
Lancet HIV 2021 Sep;8(9):e531-e543. Epub 2021 Jul 30 doi: 10.1016/S2352-3018(21)00108-9. PMID: 34339628Free PMC Article
Pathology of Anal Cancer.
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037
Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up.
Glynne-Jones R, Nilsson PJ, Aschele C, Goh V, Peiffert D, Cervantes A, Arnold D; European Society for Medical Oncology (ESMO); European Society of Surgical Oncology (ESSO); European Society of Radiotherapy and Oncology (ESTRO)
Eur J Surg Oncol 2014 Oct;40(10):1165-76. doi: 10.1016/j.ejso.2014.07.030. PMID: 25239441
Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up.
Glynne-Jones R, Nilsson PJ, Aschele C, Goh V, Peiffert D, Cervantes A, Arnold D; ESMO; ESSO; ESTRO
Radiother Oncol 2014 Jun;111(3):330-9. Epub 2014 Jun 16 doi: 10.1016/j.radonc.2014.04.013. PMID: 24947004
Diagnostic problems in anal pathology.
Longacre TA, Kong CS, Welton ML
Adv Anat Pathol 2008 Sep;15(5):263-78. doi: 10.1097/PAP.0b013e318183234b. PMID: 18724100

Recent systematic reviews

Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.
Wei F, Gaisa MM, D'Souza G, Xia N, Giuliano AR, Hawes SE, Gao L, Cheng SH, Donà MG, Goldstone SE, Schim van der Loeff MF, Neukam K, Meites E, Poynten IM, Dai J, Combes JD, Wieland U, Burgos J, Wilkin TJ, Hernandez AL, Iribarren Díaz M, Hidalgo-Tenorio C, Valencia Arredondo M, Nyitray AG, Wentzensen N, Chow EP, Smelov V, Nowak RG, Phanuphak N, Woo YL, Choi Y, Hu Y, Schofield AM, Woestenberg PJ, Chikandiwa AT, Hickey AC, de Pokomandy A, Murenzi G, Péré H, Del Pino M, Ortiz AP, Charnot-Katsikas A, Liu X, Chariyalertsak S, Strong C, Ong JJ, Yunihastuti E, Etienney I, Ferré VM, Zou H, Segondy M, Chinyowa S, Alberts CJ, Clifford GM
Lancet HIV 2021 Sep;8(9):e531-e543. Epub 2021 Jul 30 doi: 10.1016/S2352-3018(21)00108-9. PMID: 34339628Free PMC Article

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