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Elevated cancer Ag 19-9 level

MedGen UID:
1706180
•Concept ID:
C5139284
•
Finding
HPO: HP:0032345

Definition

An abnormal increased in the amount of the carbohydrate antigen 19-9, a recognizable sialo-ganglioside in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated cancer Ag 19-9 level

Professional guidelines

PubMed

Serum Carboxypeptidase Activity and Genotype-Stratified CA19-9 to Detect Early-Stage Pancreatic Cancer.
Tanaka H, Tamura K, Abe T, Yoshida T, Macgregor-Das A, Dbouk M, Blackford AL, Borges M, Lennon AM, He J, Burkhart R, Canto MI, Goggins M
Clin Gastroenterol Hepatol 2022 Oct;20(10):2267-2275.e2. Epub 2021 Oct 12 doi: 10.1016/j.cgh.2021.10.008. PMID: 34648951Free PMC Article
Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer.
Rah B, Banday MA, Bhat GR, Shah OJ, Jeelani H, Kawoosa F, Yousuf T, Afroze D
World J Gastroenterol 2021 Sep 28;27(36):6093-6109. doi: 10.3748/wjg.v27.i36.6093. PMID: 34629822Free PMC Article
Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis.
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article

Recent clinical studies

Etiology

Etiologies of remarkably elevated serum levels of carbohydrate antigen 19-9.
Zhang H, Jia L, Xu Y
J BUON 2021 Jul-Aug;26(4):1653-1658. PMID: 34565032
Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF).
Bourdel N, Huchon C, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:492-501. Epub 2020 Nov 20 doi: 10.1016/j.ejogrb.2020.11.045. PMID: 33262005
Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer.
Feng F, Tian Y, Xu G, Liu Z, Liu S, Zheng G, Guo M, Lian X, Fan D, Zhang H
BMC Cancer 2017 Nov 9;17(1):737. doi: 10.1186/s12885-017-3738-y. PMID: 29121872Free PMC Article
The clinical significance of elevated levels of serum CA 19-9.
Pavai S, Yap SF
Med J Malaysia 2003 Dec;58(5):667-72. PMID: 15190651

Diagnosis

Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Dilemma of elevated CA 19-9 in biliary pathology.
Tsen A, Barbara M, Rosenkranz L
Pancreatology 2018 Dec;18(8):862-867. Epub 2018 Sep 18 doi: 10.1016/j.pan.2018.09.004. PMID: 30249386
Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer.
Feng F, Tian Y, Xu G, Liu Z, Liu S, Zheng G, Guo M, Lian X, Fan D, Zhang H
BMC Cancer 2017 Nov 9;17(1):737. doi: 10.1186/s12885-017-3738-y. PMID: 29121872Free PMC Article
CA 19-9: Biochemical and Clinical Aspects.
Scarà S, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:247-60. doi: 10.1007/978-94-017-7215-0_15. PMID: 26530370
The clinical significance of elevated levels of serum CA 19-9.
Pavai S, Yap SF
Med J Malaysia 2003 Dec;58(5):667-72. PMID: 15190651

Therapy

Predictive Factors for Elevated Postoperative Carbohydrate Antigen 19-9 Levels in Patients With Resected Pancreatic Cancer.
Takagi C, Kikuchi Y, Shirakawa H, Hoshimoto S, Tomikawa M, Ozawa I, Hishinuma S, Ogata Y
Anticancer Res 2019 Jun;39(6):3177-3183. doi: 10.21873/anticanres.13455. PMID: 31177164
Elevated Pretreatment CEA and CA19-9 Levels are Related to Early Treatment Failure in Esophageal Adenocarcinoma.
van der Kaaij RT, Voncken FEM, van Dieren JM, Snaebjornsson P, Korse CM, Grootscholten C, Aleman BMP, van Sandick JW
Am J Clin Oncol 2019 Apr;42(4):345-350. doi: 10.1097/COC.0000000000000525. PMID: 30724779
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease.
Hong JY, Jang SH, Kim SY, Chung KS, Song JH, Park MS, Kim YS, Kim SK, Chang J, Kang YA
Braz J Infect Dis 2016 Jan-Feb;20(1):26-32. Epub 2015 Nov 22 doi: 10.1016/j.bjid.2015.09.005. PMID: 26613892Free PMC Article
Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis.
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article
Autoimmune cholangitis and cholangiocarcinoma.
Li J, Zhao C, Shen Y
J Gastroenterol Hepatol 2012 Dec;27(12):1783-9. doi: 10.1111/j.1440-1746.2012.07287.x. PMID: 23034143

Prognosis

Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Dilemma of elevated CA 19-9 in biliary pathology.
Tsen A, Barbara M, Rosenkranz L
Pancreatology 2018 Dec;18(8):862-867. Epub 2018 Sep 18 doi: 10.1016/j.pan.2018.09.004. PMID: 30249386
Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer.
Feng F, Tian Y, Xu G, Liu Z, Liu S, Zheng G, Guo M, Lian X, Fan D, Zhang H
BMC Cancer 2017 Nov 9;17(1):737. doi: 10.1186/s12885-017-3738-y. PMID: 29121872Free PMC Article
CA 19-9: Biochemical and Clinical Aspects.
Scarà S, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:247-60. doi: 10.1007/978-94-017-7215-0_15. PMID: 26530370
The clinical significance of elevated levels of serum CA 19-9.
Pavai S, Yap SF
Med J Malaysia 2003 Dec;58(5):667-72. PMID: 15190651

Clinical prediction guides

Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF).
Bourdel N, Huchon C, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:492-501. Epub 2020 Nov 20 doi: 10.1016/j.ejogrb.2020.11.045. PMID: 33262005
Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Elevated CEA and CA19-9 serum levels independently predict advanced pancreatic cancer at diagnosis.
van Manen L, Groen JV, Putter H, Vahrmeijer AL, Swijnenburg RJ, Bonsing BA, Mieog JSD
Biomarkers 2020 Mar;25(2):186-193. Epub 2020 Feb 13 doi: 10.1080/1354750X.2020.1725786. PMID: 32009482
CA 19-9: Biochemical and Clinical Aspects.
Scarà S, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:247-60. doi: 10.1007/978-94-017-7215-0_15. PMID: 26530370
Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis.
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article

Recent systematic reviews

Elevated serum CA 19-9 level associated with a splenic cyst: which is the actual clinical management? Review of the literature.
Bresadola V, Pravisani R, Terrosu G, Risaliti A
Ann Ital Chir 2015 Jan-Feb;86(1):22-9. PMID: 25819406
Systematic review of prognostic factors related to overall survival in patients with stage IV colorectal cancer and unresectable metastases.
Stillwell AP, Ho YH, Veitch C
World J Surg 2011 Mar;35(3):684-92. doi: 10.1007/s00268-010-0891-8. PMID: 21181473
Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer.
Goonetilleke KS, Siriwardena AK
Eur J Surg Oncol 2007 Apr;33(3):266-70. Epub 2006 Nov 9 doi: 10.1016/j.ejso.2006.10.004. PMID: 17097848

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