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Increased circulating mannose-binding protein concentration

MedGen UID:
1706367
•Concept ID:
C5139262
•
Finding
Synonym: Increased mannose-binding protein level
 
HPO: HP:0032306

Definition

An abnormal elevation above the normal concentration of mannose-binding protein in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating mannose-binding protein concentration

Recent clinical studies

Etiology

Circulating mannose-binding lectin concentration in patients with stable coronary artery disease is associated with heart failure and renal function.
Yu TH, Wu CC, Tsai IT, Hsuan CF, Lee TL, Wang CP, Wei CT, Chung FM, Lee YJ, Hung WC, Tang WH
Clin Chim Acta 2023 Aug 1;548:117528. Epub 2023 Aug 26 doi: 10.1016/j.cca.2023.117528. PMID: 37640132
l-ficolin-MASP arm of the complement system in schizophrenia.
Mayilyan KR, Krarup A, Soghoyan AF, Jensenius JC, Sim RB
Immunobiology 2023 Mar;228(2):152349. Epub 2023 Feb 15 doi: 10.1016/j.imbio.2023.152349. PMID: 36805857
Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.
Østergaard JA, Thiel S, Hoffmann-Petersen IT, Hovind P, Parving HH, Tarnow L, Rossing P, Hansen TK
Diabetes Metab Res Rev 2017 Jul;33(5) Epub 2017 Apr 11 doi: 10.1002/dmrr.2895. PMID: 28303635
Mannose-Binding Lectin: Biologic Characteristics and Role in the Susceptibility to Infections and Ischemia-Reperfusion Related Injury in Critically Ill Neonates.
Auriti C, Prencipe G, Moriondo M, Bersani I, Bertaina C, Mondì V, Inglese R
J Immunol Res 2017;2017:7045630. Epub 2017 Jan 26 doi: 10.1155/2017/7045630. PMID: 28246614Free PMC Article
Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal J, Malla B, Steffensen R, Costa L, Egli A, Trendelenburg M, Blasi F, Kostikas K, Welte T, Torres A, Louis R, Boersma W, Milenkovic B, Aerts J, Rohde GG, Lacoma A, Rentsch K, Roth M, Tamm M, Stolz D
Respir Res 2015 Dec 18;16:150. doi: 10.1186/s12931-015-0306-3. PMID: 26684757Free PMC Article

Diagnosis

l-ficolin-MASP arm of the complement system in schizophrenia.
Mayilyan KR, Krarup A, Soghoyan AF, Jensenius JC, Sim RB
Immunobiology 2023 Mar;228(2):152349. Epub 2023 Feb 15 doi: 10.1016/j.imbio.2023.152349. PMID: 36805857
Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel.
Zachar R, Thiel S, Hansen S, Henriksen ML, Skjoedt MO, Skjodt K, Hamzaei Z, Madsen K, Lund L, Hummler E, Svenningsen P, Jensen BL
Sci Rep 2022 Sep 24;12(1):15955. doi: 10.1038/s41598-022-20213-8. PMID: 36153401Free PMC Article
Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.
Østergaard JA, Thiel S, Hoffmann-Petersen IT, Hovind P, Parving HH, Tarnow L, Rossing P, Hansen TK
Diabetes Metab Res Rev 2017 Jul;33(5) Epub 2017 Apr 11 doi: 10.1002/dmrr.2895. PMID: 28303635
Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal J, Malla B, Steffensen R, Costa L, Egli A, Trendelenburg M, Blasi F, Kostikas K, Welte T, Torres A, Louis R, Boersma W, Milenkovic B, Aerts J, Rohde GG, Lacoma A, Rentsch K, Roth M, Tamm M, Stolz D
Respir Res 2015 Dec 18;16:150. doi: 10.1186/s12931-015-0306-3. PMID: 26684757Free PMC Article
Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency.
Schafranski MD, Stier A, Nisihara R, Messias-Reason IJ
Clin Exp Immunol 2004 Dec;138(3):521-5. doi: 10.1111/j.1365-2249.2004.02645.x. PMID: 15544631Free PMC Article

Therapy

Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2.
Nielsen TL, Pilely K, Lund KP, Warming PE, Plesner LL, Iversen KK, Garred P
Hemodial Int 2021 Oct;25(4):479-488. Epub 2021 Jun 16 doi: 10.1111/hdi.12948. PMID: 34132045
Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial.
Lindberg-Larsen V, Kehlet H, Pilely K, Bagger J, Rovsing ML, Garred P
Clin Exp Immunol 2018 Mar;191(3):356-362. Epub 2017 Nov 9 doi: 10.1111/cei.13071. PMID: 29119559Free PMC Article
Mannose-Binding Lectin: Biologic Characteristics and Role in the Susceptibility to Infections and Ischemia-Reperfusion Related Injury in Critically Ill Neonates.
Auriti C, Prencipe G, Moriondo M, Bersani I, Bertaina C, Mondì V, Inglese R
J Immunol Res 2017;2017:7045630. Epub 2017 Jan 26 doi: 10.1155/2017/7045630. PMID: 28246614Free PMC Article
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction.
Ueland T, Espevik T, Kjekshus J, Gullestad L, Omland T, Squire IB, Frøland SS, Mollnes TE, Dickstein K, Aukrust P
J Card Fail 2006 Oct;12(8):659-63. doi: 10.1016/j.cardfail.2006.07.002. PMID: 17045187
Mannan-binding lectin and hepatitis C infection.
Kilpatrick DC, Delahooke TE, Koch C, Turner ML, Hayes PC
Clin Exp Immunol 2003 Apr;132(1):92-5. doi: 10.1046/j.1365-2249.2003.02122.x. PMID: 12653842Free PMC Article

Prognosis

Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.
Østergaard JA, Thiel S, Hoffmann-Petersen IT, Hovind P, Parving HH, Tarnow L, Rossing P, Hansen TK
Diabetes Metab Res Rev 2017 Jul;33(5) Epub 2017 Apr 11 doi: 10.1002/dmrr.2895. PMID: 28303635
Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal J, Malla B, Steffensen R, Costa L, Egli A, Trendelenburg M, Blasi F, Kostikas K, Welte T, Torres A, Louis R, Boersma W, Milenkovic B, Aerts J, Rohde GG, Lacoma A, Rentsch K, Roth M, Tamm M, Stolz D
Respir Res 2015 Dec 18;16:150. doi: 10.1186/s12931-015-0306-3. PMID: 26684757Free PMC Article
Mannose-binding lectin levels and variation during invasive candidiasis.
Damiens S, Poissy J, François N, Salleron J, Jawhara S, Jouault T, Poulain D, Sendid B
J Clin Immunol 2012 Dec;32(6):1317-23. Epub 2012 Jul 26 doi: 10.1007/s10875-012-9748-2. PMID: 22833166
Serum mannan-binding lectin levels in patients with celiac disease: an analysis of clinical and autoimmune features.
de Carvalho EG, da Rosa Utiyama SR, da Silva Kotze LM, de Messias Reason IT
Dig Dis Sci 2007 Sep;52(9):2145-51. Epub 2007 Mar 28 doi: 10.1007/s10620-007-9792-6. PMID: 17393323
Mannan-binding lectin and hepatitis C infection.
Kilpatrick DC, Delahooke TE, Koch C, Turner ML, Hayes PC
Clin Exp Immunol 2003 Apr;132(1):92-5. doi: 10.1046/j.1365-2249.2003.02122.x. PMID: 12653842Free PMC Article

Clinical prediction guides

l-ficolin-MASP arm of the complement system in schizophrenia.
Mayilyan KR, Krarup A, Soghoyan AF, Jensenius JC, Sim RB
Immunobiology 2023 Mar;228(2):152349. Epub 2023 Feb 15 doi: 10.1016/j.imbio.2023.152349. PMID: 36805857
Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal J, Malla B, Steffensen R, Costa L, Egli A, Trendelenburg M, Blasi F, Kostikas K, Welte T, Torres A, Louis R, Boersma W, Milenkovic B, Aerts J, Rohde GG, Lacoma A, Rentsch K, Roth M, Tamm M, Stolz D
Respir Res 2015 Dec 18;16:150. doi: 10.1186/s12931-015-0306-3. PMID: 26684757Free PMC Article
Functional interaction of cockroach allergens and mannose receptor (CD206) in human circulating fibrocytes.
Tsai YM, Hsu SC, Zhang J, Zhou YF, Plunkett B, Huang SK, Gao PS
PLoS One 2013;8(5):e64105. Epub 2013 May 29 doi: 10.1371/journal.pone.0064105. PMID: 23734186Free PMC Article
Mannose-binding lectin levels and variation during invasive candidiasis.
Damiens S, Poissy J, François N, Salleron J, Jawhara S, Jouault T, Poulain D, Sendid B
J Clin Immunol 2012 Dec;32(6):1317-23. Epub 2012 Jul 26 doi: 10.1007/s10875-012-9748-2. PMID: 22833166
Functional analysis of the mannose-binding lectin complement pathway in normal pregnancy and preeclampsia.
Csuka D, Molvarec A, Derzsy Z, Varga L, Füst G, Rigó J Jr, Prohászka Z
J Reprod Immunol 2010 Dec;87(1-2):90-6. Epub 2010 Oct 16 doi: 10.1016/j.jri.2010.07.004. PMID: 20952075

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