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Sural nerve atrophy

MedGen UID:
1706390
•Concept ID:
C5139159
•
Pathologic Function
Synonym: Atrophy of sural nerve
 
HPO: HP:0032145

Definition

Wasting of the sural nerve, a sensory nerve in the calf region of the leg. [from HPO]

Professional guidelines

PubMed

Primary achilles tendon repair with mini-dorsolateral incision technique and accelerated rehabilitation.
Hrnack SA, Crates JM, Barber FA
Foot Ankle Int 2012 Oct;33(10):848-51. doi: 10.3113/FAI.2012.0848. PMID: 23050708
MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2.
Verhoeven K, Claeys KG, Züchner S, Schröder JM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec R, Saifi GM, Szigeti K, Mancias P, Butler IJ, Kochanski A, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N, Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev I, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen HJ, Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V
Brain 2006 Aug;129(Pt 8):2093-102. Epub 2006 May 19 doi: 10.1093/brain/awl126. PMID: 16714318
Correlation of neuromuscular pathology in acquired immune deficiency syndrome patients with cytomegalovirus infection and zidovudine treatment.
Cornford ME, Ho HW, Vinters HV
Acta Neuropathol 1992;84(5):516-29. doi: 10.1007/BF00304471. PMID: 1334328

Recent clinical studies

Etiology

Nerve ultrasound detects abnormally small nerves in patients with spinal and bulbar muscular atrophy.
Pelosi L, Ghosh A, Leadbetter R, Lance S, Rodrigues M, Roxburgh R
Muscle Nerve 2022 May;65(5):599-602. Epub 2022 Feb 14 doi: 10.1002/mus.27509. PMID: 35092036
Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.
Rong Z, Shen F, Wang Y, Sun L, Wu J, Zhang H, Yuan Y, Jiang W, Li X, Ji P, Zhang K
Neurosci Lett 2021 Jun 21;756:135964. Epub 2021 May 19 doi: 10.1016/j.neulet.2021.135964. PMID: 34022266
Cranial nerve involvement in Charcot-Marie-Tooth Disease.
Das N, Kandalaft S, Wu X, Malhotra A
J Clin Neurosci 2017 Mar;37:59-62. Epub 2016 Nov 22 doi: 10.1016/j.jocn.2016.10.049. PMID: 27884603
Peripheral nerve abnormalities in pediatric patients with spinal muscular atrophy.
Yonekawa T, Komaki H, Saito Y, Sugai K, Sasaki M
Brain Dev 2013 Feb;35(2):165-71. Epub 2012 Apr 17 doi: 10.1016/j.braindev.2012.03.009. PMID: 22512990
Microsurgical management of hypoglossal schwannomas over 3 decades: a modified grading scale to guide surgical approach.
Nonaka Y, Grossi PM, Bulsara KR, Taniguchi RM, Friedman AH, Fukushima T
Neurosurgery 2011 Dec;69(2 Suppl Operative):ons121-40; discussion ons140. doi: 10.1227/NEU.0b013e31822a547b. PMID: 21709593

Diagnosis

A TRPV4 mutation caused Charcot-Marie-Tooth disease type 2C with scapuloperoneal muscular atrophy overlap syndrome and scapuloperoneal spinal muscular atrophy in one family: a case report and literature review.
Chen H, Sun C, Zheng Y, Yin J, Gao M, Zhao C, Lin J
BMC Neurol 2023 Jun 30;23(1):250. doi: 10.1186/s12883-023-03260-0. PMID: 37391745Free PMC Article
Evaluation of simultaneous muscle and nerve biopsies for the diagnosis of neuromuscular diseases.
Chen DJ, Prayson RA
Ann Diagn Pathol 2014 Oct;18(5):282-5. Epub 2014 Aug 8 doi: 10.1016/j.anndiagpath.2014.08.001. PMID: 25178852
Peripheral nerve entrapments.
Hirose CB, McGarvey WC
Foot Ankle Clin 2004 Jun;9(2):255-69. doi: 10.1016/j.fcl.2004.02.001. PMID: 15165581
Current principles in microsurgical nerve repair.
Hausamen JE, Schmelzeisen R
Br J Oral Maxillofac Surg 1996 Apr;34(2):143-57. doi: 10.1016/s0266-4356(96)90369-1. PMID: 8861290
Churg-Strauss syndrome.
Gargulinski RB, Simpson DA, Wishnow R, Rentz LE, Jones MZ
J Am Osteopath Assoc 1996 Jul;96(7):428-32. PMID: 8758878

Therapy

Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.
Sevilla T, Lupo V, Martínez-Rubio D, Sancho P, Sivera R, Chumillas MJ, García-Romero M, Pascual-Pascual SI, Muelas N, Dopazo J, Vílchez JJ, Palau F, Espinós C
Brain 2016 Jan;139(Pt 1):62-72. Epub 2015 Oct 24 doi: 10.1093/brain/awv311. PMID: 26497905
Churg-Strauss syndrome.
Gargulinski RB, Simpson DA, Wishnow R, Rentz LE, Jones MZ
J Am Osteopath Assoc 1996 Jul;96(7):428-32. PMID: 8758878
What causes neuropathic pain?
Boulton A
J Diabetes Complications 1992 Jan-Mar;6(1):58-63. doi: 10.1016/1056-8727(92)90050-u. PMID: 1562760
Ethylene oxide polyneuropathy.
Kuzuhara S, Kanazawa I, Nakanishi T, Egashira T
Neurology 1983 Mar;33(3):377-80. doi: 10.1212/wnl.33.3.377. PMID: 6298660
Glue sniffer's neuropathy.
Towfighi J, Gonatas NK, Pleasure D, Cooper HS, McCree L
Neurology 1976 Mar;26(3):238-43. doi: 10.1212/wnl.26.3.238. PMID: 175315

Prognosis

Clinical, neurophysiological and morphological study of dominant intermediate Charcot-Marie-Tooth type C neuropathy.
Thomas FP, Guergueltcheva V, Gondim FA, Tournev I, Rao CV, Ishpekova B, Kinsella LJ, Pan Y, Geller TJ, Litvinenko I, De Jonghe P, Scherer SS, Jordanova A
J Neurol 2016 Mar;263(3):467-76. Epub 2016 Jan 2 doi: 10.1007/s00415-015-7989-8. PMID: 26725087
Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.
Lossos A, Elazar N, Lerer I, Schueler-Furman O, Fellig Y, Glick B, Zimmerman BE, Azulay H, Dotan S, Goldberg S, Gomori JM, Ponger P, Newman JP, Marreed H, Steck AJ, Schaeren-Wiemers N, Mor N, Harel M, Geiger T, Eshed-Eisenbach Y, Meiner V, Peles E
Brain 2015 Sep;138(Pt 9):2521-36. Epub 2015 Jul 15 doi: 10.1093/brain/awv204. PMID: 26179919Free PMC Article
Muscle atrophy in chronic inflammatory demyelinating polyneuropathy: a computed tomography assessment.
Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G
Eur J Neurol 2014 Jul;21(7):1002-10. Epub 2014 Mar 29 doi: 10.1111/ene.12426. PMID: 24684299
Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy.
Chance PF
Neuromolecular Med 2006;8(1-2):159-74. doi: 10.1385/NMM:8:1:159. PMID: 16775374
Peripheral nerve entrapments.
Hirose CB, McGarvey WC
Foot Ankle Clin 2004 Jun;9(2):255-69. doi: 10.1016/j.fcl.2004.02.001. PMID: 15165581

Clinical prediction guides

Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.
Rong Z, Shen F, Wang Y, Sun L, Wu J, Zhang H, Yuan Y, Jiang W, Li X, Ji P, Zhang K
Neurosci Lett 2021 Jun 21;756:135964. Epub 2021 May 19 doi: 10.1016/j.neulet.2021.135964. PMID: 34022266
Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy.
Higuchi Y, Okunushi R, Hara T, Hashiguchi A, Yuan J, Yoshimura A, Murayama K, Ohtake A, Ando M, Hiramatsu Y, Ishihara S, Tanabe H, Okamoto Y, Matsuura E, Ueda T, Toda T, Yamashita S, Yamada K, Koide T, Yaguchi H, Mitsui J, Ishiura H, Yoshimura J, Doi K, Morishita S, Sato K, Nakagawa M, Yamaguchi M, Tsuji S, Takashima H
Brain 2018 Jun 1;141(6):1622-1636. doi: 10.1093/brain/awy104. PMID: 29718187Free PMC Article
Genetic and clinical characteristics of NEFL-related Charcot-Marie-Tooth disease.
Horga A, Laurà M, Jaunmuktane Z, Jerath NU, Gonzalez MA, Polke JM, Poh R, Blake JC, Liu YT, Wiethoff S, Bettencourt C, Lunn MP, Manji H, Hanna MG, Houlden H, Brandner S, Züchner S, Shy M, Reilly MM
J Neurol Neurosurg Psychiatry 2017 Jul;88(7):575-585. Epub 2017 May 13 doi: 10.1136/jnnp-2016-315077. PMID: 28501821Free PMC Article
Overview of hereditary neuropathy with liability to pressure palsies.
Chance PF
Ann N Y Acad Sci 1999 Sep 14;883:14-21. PMID: 10586225
What causes neuropathic pain?
Boulton A
J Diabetes Complications 1992 Jan-Mar;6(1):58-63. doi: 10.1016/1056-8727(92)90050-u. PMID: 1562760

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