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Bladder Embryonal Rhabdomyosarcoma

MedGen UID:
1707365
•Concept ID:
C2212625
•
Neoplastic Process

Definition

An embryonal rhabdomyosarcoma arising from the bladder. It is the most common type of rhabdomyosarcoma of the bladder affecting young children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Embryonal Rhabdomyosarcoma

Professional guidelines

PubMed

Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma.
Zhan XK, Zhang S, Cao BW, Wang JW, Li JL, Sun YK, Zhang W, Yang L, Zhou AP, Chi YH, Li YX, Ma JH, Li CL
World J Surg Oncol 2015 May 28;13:190. doi: 10.1186/s12957-015-0574-x. PMID: 26018798Free PMC Article
Management of stage I cervical sarcoma botryoides in childhood and adolescence.
Gruessner SE, Omwandho CO, Dreyer T, Blütters-Sawatzki R, Reiter A, Tinneberg HR, Bohle RM
Eur J Pediatr 2004 Aug;163(8):452-6. Epub 2004 Jun 2 doi: 10.1007/s00431-004-1469-y. PMID: 15173941
Management of embryonal rhabdomyosarcoma in children.
Exelby PR
Surg Clin North Am 1974 Aug;54(4):849-57. doi: 10.1016/s0039-6109(16)40388-9. PMID: 4610841

Recent clinical studies

Etiology

Bladder function after conservative surgery and high-dose rate brachytherapy for bladder-prostate rhabdomyosarcoma.
Lobo S, Gaze MN, Slater O, Hoskin P, Sands G, Sullivan T, Cho A, Eminowicz G, Smeulders N
Pediatr Blood Cancer 2022 Aug;69(8):e29574. Epub 2022 Jan 19 doi: 10.1002/pbc.29574. PMID: 35044080
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644
Pelvic neoplasms in children.
Groff DB
J Surg Oncol 2001 May;77(1):65-71. doi: 10.1002/jso.1068. PMID: 11344486
Bladder/prostate rhabdomyosarcoma: results of the multi-institutional trials of the Intergroup Rhabdomyosarcoma Study.
Hays DM
Semin Surg Oncol 1993 Nov-Dec;9(6):520-3. doi: 10.1002/ssu.2980090610. PMID: 8284571

Diagnosis

Defining an embryonal rhabdomyosarcoma endotype.
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Neurofibromatosis-1 and Rhabdomyosarcoma: An Unusual Recurrence.
Halstead NV, Cost NG, Hecht SL, Walker JP
Urology 2020 Mar;137:168-172. Epub 2019 Nov 30 doi: 10.1016/j.urology.2019.11.026. PMID: 31794814
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644
Pelvic neoplasms in children.
Groff DB
J Surg Oncol 2001 May;77(1):65-71. doi: 10.1002/jso.1068. PMID: 11344486
Ureteral rhabdomyosarcoma.
Townsend MF 3rd, Gal AA, Thoms WW, Newman JL, Eble JN, Graham SD Jr
Urology 1999 Sep;54(3):561. doi: 10.1016/s0090-4295(99)00161-2. PMID: 10754139

Therapy

Bladder function after conservative surgery and high-dose rate brachytherapy for bladder-prostate rhabdomyosarcoma.
Lobo S, Gaze MN, Slater O, Hoskin P, Sands G, Sullivan T, Cho A, Eminowicz G, Smeulders N
Pediatr Blood Cancer 2022 Aug;69(8):e29574. Epub 2022 Jan 19 doi: 10.1002/pbc.29574. PMID: 35044080
Disease Control and Patterns of Failure After Proton Beam Therapy for Rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Int J Radiat Oncol Biol Phys 2021 Mar 1;109(3):718-725. doi: 10.1016/j.ijrobp.2020.09.050. PMID: 33516439
Defining an embryonal rhabdomyosarcoma endotype.
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Nov;66(11):e27952. Epub 2019 Aug 9 doi: 10.1002/pbc.27952. PMID: 31397065
Bladder/prostate rhabdomyosarcoma: results of the multi-institutional trials of the Intergroup Rhabdomyosarcoma Study.
Hays DM
Semin Surg Oncol 1993 Nov-Dec;9(6):520-3. doi: 10.1002/ssu.2980090610. PMID: 8284571

Prognosis

Defining an embryonal rhabdomyosarcoma endotype.
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Future directions in risk stratification and therapy for advanced pediatric genitourinary rhabdomyosarcoma.
Harel M, Ferrer FA, Shapiro LH, Makari JH
Urol Oncol 2016 Feb;34(2):103-15. Epub 2015 Oct 28 doi: 10.1016/j.urolonc.2015.09.013. PMID: 26519985
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know.
Faure A, Atkinson J, Bouty A, O'Brien M, Levard G, Hutson J, Heloury Y
J Pediatr Urol 2016 Feb;12(1):5-10. Epub 2015 Sep 26 doi: 10.1016/j.jpurol.2015.08.012. PMID: 26454454
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Clinical prediction guides

Disease Control and Patterns of Failure After Proton Beam Therapy for Rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Int J Radiat Oncol Biol Phys 2021 Mar 1;109(3):718-725. doi: 10.1016/j.ijrobp.2020.09.050. PMID: 33516439
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Nov;66(11):e27952. Epub 2019 Aug 9 doi: 10.1002/pbc.27952. PMID: 31397065
Patterns of Failure in Pediatric Rhabdomyosarcoma After Proton Therapy.
Vern-Gross TZ, Indelicato DJ, Bradley JA, Rotondo RL
Int J Radiat Oncol Biol Phys 2016 Dec 1;96(5):1070-1077. Epub 2016 Aug 30 doi: 10.1016/j.ijrobp.2016.08.028. PMID: 27742542
Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma.
Zhan XK, Zhang S, Cao BW, Wang JW, Li JL, Sun YK, Zhang W, Yang L, Zhou AP, Chi YH, Li YX, Ma JH, Li CL
World J Surg Oncol 2015 May 28;13:190. doi: 10.1186/s12957-015-0574-x. PMID: 26018798Free PMC Article
Primary mesenchymal tumors of the urinary bladder. A histological and immunohistochemical study of 30 cases.
Kunze E, Theuring F, Krüger G
Pathol Res Pract 1994 Apr;190(4):311-32. doi: 10.1016/S0344-0338(11)80404-8. PMID: 8078801

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