U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased specific antibody response to protein-conjugated polysaccharide vaccine

MedGen UID:
1708120
•Concept ID:
C5139465
•
Finding
HPO: HP:0410302

Definition

A reduced ability to synthesize postvaccination antibodies against protein-conjugated polysaccharides in vaccines, as measured by antibody titer determination following vaccination. [from HPO]

Conditions with this feature

Immunodeficiency, common variable, 15
MedGen UID:
1847802
•Concept ID:
C5882741
•
Disease or Syndrome
Common variable immunodeficiency-15 (CVID15) is an autosomal dominant immunologic disorder characterized by the onset of severe recurrent infections in infancy or early childhood. Laboratory studies show hypogammaglobulinemia with antibody deficiencies of IgM, IgG, and IgA due to impaired plasma cell homeostasis, although other B cell subset numbers are normal. T and NK cells are also normal. Treatment with IV Ig results in a favorable clinical response to recurrent infections (Schubert et al., 2018). For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (607594).
See: Condition Record
Immunodeficiency, common variable, 15

Recent clinical studies

Therapy

Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells.
Clutterbuck EA, Lazarus R, Yu LM, Bowman J, Bateman EA, Diggle L, Angus B, Peto TE, Beverley PC, Mant D, Pollard AJ
J Infect Dis 2012 May 1;205(9):1408-16. Epub 2012 Mar 29 doi: 10.1093/infdis/jis212. PMID: 22457293Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On
    • Decreased specific antibody response to protein-conjugated polysaccharide vaccin...
      Decreased specific antibody response to protein-conjugated polysaccharide vaccine
      MedGen
    • Granuloma, Lethal Midline
      Granuloma, Lethal Midline
      A condition that is characterized by inflammation, ulceration, and perforation of the nose and the PALATE with progressive destruction of midline facial structures. This syndr...<br/>Year introduced: 1965
      MeSH
    • Fibromuscular Dysplasia
      Fibromuscular Dysplasia
      An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of ...<br/>Year introduced: 1991(1978)
      MeSH
    • Anterior Compartment Syndrome
      Anterior Compartment Syndrome
      Rapid swelling, increased tension, pain, and ischemic necrosis of the muscles of the anterior tibial compartment of the leg, often following excessive PHYSICAL EXERTION....<br/>Year introduced: 1991(1981)1972
      MeSH
    • Gram-Negative Bacterial Infections
      Gram-Negative Bacterial Infections
      Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.<br/>Year introduced: 1992
      MeSH

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...