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Increased helper T cell proportion

MedGen UID:
1708381
Concept ID:
C5398014
Finding
Synonyms: Elevated helper T cell proportion; Increased proportion T-helper cells
 
HPO: HP:0500264

Definition

Increased proportion of helper T cells relative to the total number of T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased helper T cell proportion

Professional guidelines

PubMed

Zhao J, Chen Y, Li L, Yin H, Song S, Wang Y, Feng X, Fan X, Gao C, Gao L, Zhan Y, Zhao M, Li X, Lu Q
Int J Biol Sci 2024;20(6):2168-2186. Epub 2024 Mar 25 doi: 10.7150/ijbs.92514. PMID: 38617532Free PMC Article
Maeda S, Hashimoto H, Maeda T, Tamechika SY, Isogai S, Naniwa T, Niimi A
Lupus Sci Med 2023 Oct;10(2) doi: 10.1136/lupus-2023-000976. PMID: 37802602Free PMC Article
Lucas C, Perdriger A, Amé P
Semin Arthritis Rheum 2020 Oct;50(5):867-872. Epub 2020 Jul 13 doi: 10.1016/j.semarthrit.2020.06.021. PMID: 32896702

Recent clinical studies

Etiology

Papadopoulos NG, Bacharier LB, Jackson DJ, Deschildre A, Phipatanakul W, Szefler SJ, Gall R, Ledanois O, Jacob-Nara JA, Sacks H
J Allergy Clin Immunol Pract 2024 Sep;12(9):2310-2324. Epub 2024 Jun 13 doi: 10.1016/j.jaip.2024.06.010. PMID: 38878861
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P
Cell 2020 Nov 25;183(5):1340-1353.e16. Epub 2020 Oct 5 doi: 10.1016/j.cell.2020.10.001. PMID: 33096020Free PMC Article
Osborne LM, Gilden J, Kamperman AM, Hoogendijk WJG, Spicer J, Drexhage HA, Bergink V
Brain Behav Immun 2020 Jul;87:397-403. Epub 2020 Jan 8 doi: 10.1016/j.bbi.2020.01.007. PMID: 31926288Free PMC Article
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

Diagnosis

Papadopoulos NG, Bacharier LB, Jackson DJ, Deschildre A, Phipatanakul W, Szefler SJ, Gall R, Ledanois O, Jacob-Nara JA, Sacks H
J Allergy Clin Immunol Pract 2024 Sep;12(9):2310-2324. Epub 2024 Jun 13 doi: 10.1016/j.jaip.2024.06.010. PMID: 38878861
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Kresovich JK, Xu Z, O'Brien KM, Parks CG, Weinberg CR, Sandler DP, Taylor JA
Hypertension 2023 Jan;80(1):43-53. Epub 2022 Oct 19 doi: 10.1161/HYPERTENSIONAHA.122.20001. PMID: 36259385Free PMC Article
Sifnaios E, Mastorakos G, Psarra K, Panagopoulos ND, Panoulis K, Vitoratos N, Rizos D, Creatsas G
In Vivo 2019 Jan-Feb;33(1):31-40. doi: 10.21873/invivo.11435. PMID: 30587599Free PMC Article
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article

Therapy

Papadopoulos NG, Bacharier LB, Jackson DJ, Deschildre A, Phipatanakul W, Szefler SJ, Gall R, Ledanois O, Jacob-Nara JA, Sacks H
J Allergy Clin Immunol Pract 2024 Sep;12(9):2310-2324. Epub 2024 Jun 13 doi: 10.1016/j.jaip.2024.06.010. PMID: 38878861
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article
Xu C, He X, Liu W, Chen Y, Zhou C, Duan Z, Lu Q, Yan X, Zhang Z, Zheng R
Int Immunopharmacol 2017 May;46:9-15. Epub 2017 Feb 27 doi: 10.1016/j.intimp.2017.02.024. PMID: 28246054
Şahin E, Bafaqeeh SA, Güven SG, Çetinkaya EA, Muluk NB, Coşkun ZO, Lopatin A, Kar M, Pinarbasli MO, Cingi C
Am J Rhinol Allergy 2016 Sep 1;30(5):1-3. doi: 10.2500/ajra.2016.30.4367. PMID: 27658024

Prognosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Lucas C, Perdriger A, Amé P
Semin Arthritis Rheum 2020 Oct;50(5):867-872. Epub 2020 Jul 13 doi: 10.1016/j.semarthrit.2020.06.021. PMID: 32896702
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M
Eur Respir J 2018 Mar;51(3) Epub 2018 Mar 1 doi: 10.1183/13993003.01124-2017. PMID: 29449421
Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J
Gastroenterology 2017 Dec;153(6):1621-1633.e6. Epub 2017 Aug 18 doi: 10.1053/j.gastro.2017.08.022. PMID: 28823860

Clinical prediction guides

Jin SP, Lee K, Bang YJ, Jeon YH, Jung S, Choi SJ, Lee JS, Kim J, Guttman-Yassky E, Park CG, Kim HJ, Hong S, Lee DH
Allergy 2024 Jun;79(6):1584-1597. doi: 10.1111/all.16121. PMID: 38817208
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P
Cell 2020 Nov 25;183(5):1340-1353.e16. Epub 2020 Oct 5 doi: 10.1016/j.cell.2020.10.001. PMID: 33096020Free PMC Article
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J
Gastroenterology 2017 Dec;153(6):1621-1633.e6. Epub 2017 Aug 18 doi: 10.1053/j.gastro.2017.08.022. PMID: 28823860
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L
Cell Mol Immunol 2017 May;14(5):423-431. Epub 2015 Oct 5 doi: 10.1038/cmi.2015.89. PMID: 26435067Free PMC Article

Recent systematic reviews

Huang J, Li X, Zhu Q, Wang M, Xie Z, Zhao T
Front Immunol 2024;15:1425847. Epub 2024 Jul 17 doi: 10.3389/fimmu.2024.1425847. PMID: 39086480Free PMC Article
Mao Y, Yang C, Tang L, Liu G, Cheng L, Chen M
Ann Palliat Med 2021 Dec;10(12):12801-12809. doi: 10.21037/apm-21-3590. PMID: 35016438
Burns G, Carroll G, Mathe A, Horvat J, Foster P, Walker MM, Talley NJ, Keely S
Am J Gastroenterol 2019 Mar;114(3):429-436. doi: 10.1038/s41395-018-0377-0. PMID: 30839392

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