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Refractory Small Cell Glioblastoma

MedGen UID:
1708479
•Concept ID:
C5235850
•
Neoplastic Process

Definition

A small cell glioblastoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Small Cell Glioblastoma

Professional guidelines

PubMed

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.
Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG
Genome Res 2015 Mar;25(3):316-27. Epub 2015 Feb 3 doi: 10.1101/gr.180612.114. PMID: 25650244Free PMC Article
Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.
Triscott J, Rose Pambid M, Dunn SE
Stem Cells 2015 Apr;33(4):1042-6. doi: 10.1002/stem.1956. PMID: 25588723
OSU-03012 in the treatment of glioblastoma.
McCubrey JA, Lahair MM, Franklin RA
Mol Pharmacol 2006 Aug;70(2):437-9. Epub 2006 May 4 doi: 10.1124/mol.106.026252. PMID: 16675657

Recent clinical studies

Etiology

The effect of hypoxia on photodynamic therapy with 5-aminolevulinic acid in malignant gliomas.
Ihata T, Nonoguchi N, Fujishiro T, Omura N, Kawabata S, Kajimoto Y, Wanibuchi M
Photodiagnosis Photodyn Ther 2022 Dec;40:103056. Epub 2022 Aug 6 doi: 10.1016/j.pdpdt.2022.103056. PMID: 35944845
High-level Sp1 is Associated with Proliferation, Invasion, and Poor Prognosis in Astrocytoma.
Chen YT, Tsai HP, Wu CC, Chen CY, Chai CY, Kwan AL
Pathol Oncol Res 2019 Jul;25(3):1003-1013. Epub 2018 Jun 9 doi: 10.1007/s12253-018-0422-8. PMID: 29948615
INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201.
Drugs R D 2007;8(3):176-87. doi: 10.2165/00126839-200708030-00005. PMID: 17472413
In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines.
Avramis IA, Christodoulopoulos G, Suzuki A, Laug WE, Gonzalez-Gomez I, McNamara G, Sausville EA, Avramis VI
Cancer Chemother Pharmacol 2002 Dec;50(6):479-89. Epub 2002 Oct 17 doi: 10.1007/s00280-002-0507-6. PMID: 12451475
Effect of ionizing radiation on partial seizures attributable to malignant cerebral tumors.
Chalifoux R, Elisevich K
Stereotact Funct Neurosurg 1996-1997;67(3-4):169-82. doi: 10.1159/000099446. PMID: 9311074

Diagnosis

Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines.
Yamaki A, Akiyama R, Murakami C, Takao S, Murakami Y, Mizuno S, Takahashi D, Kado S, Taketomi A, Shirai Y, Goto K, Sakane F
J Cell Biochem 2019 Jun;120(6):10043-10056. Epub 2018 Dec 9 doi: 10.1002/jcb.28288. PMID: 30536880
Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors.
Garrigue P, Tang J, Ding L, Bouhlel A, Tintaru A, Laurini E, Huang Y, Lyu Z, Zhang M, Fernandez S, Balasse L, Lan W, Mas E, Marson D, Weng Y, Liu X, Giorgio S, Iovanna J, Pricl S, Guillet B, Peng L
Proc Natl Acad Sci U S A 2018 Nov 6;115(45):11454-11459. Epub 2018 Oct 22 doi: 10.1073/pnas.1812938115. PMID: 30348798Free PMC Article
Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.
Triscott J, Rose Pambid M, Dunn SE
Stem Cells 2015 Apr;33(4):1042-6. doi: 10.1002/stem.1956. PMID: 25588723
The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms.
Loew S, Schmidt U, Unterberg A, Halatsch ME
Anticancer Agents Med Chem 2009 Jul;9(6):703-15. doi: 10.2174/187152009788680019. PMID: 19601750
INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201.
Drugs R D 2007;8(3):176-87. doi: 10.2165/00126839-200708030-00005. PMID: 17472413

Therapy

Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.
Triscott J, Rose Pambid M, Dunn SE
Stem Cells 2015 Apr;33(4):1042-6. doi: 10.1002/stem.1956. PMID: 25588723
Targeting ErbB receptors in high-grade glioma.
Berezowska S, Schlegel J
Curr Pharm Des 2011;17(23):2468-87. doi: 10.2174/138161211797249233. PMID: 21827413
The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms.
Loew S, Schmidt U, Unterberg A, Halatsch ME
Anticancer Agents Med Chem 2009 Jul;9(6):703-15. doi: 10.2174/187152009788680019. PMID: 19601750
INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201.
Drugs R D 2007;8(3):176-87. doi: 10.2165/00126839-200708030-00005. PMID: 17472413
OSU-03012 in the treatment of glioblastoma.
McCubrey JA, Lahair MM, Franklin RA
Mol Pharmacol 2006 Aug;70(2):437-9. Epub 2006 May 4 doi: 10.1124/mol.106.026252. PMID: 16675657

Prognosis

Novel therapies hijack the blood-brain barrier to eradicate glioblastoma cancer stem cells.
Vengoji R, Ponnusamy MP, Rachagani S, Mahapatra S, Batra SK, Shonka N, Macha MA
Carcinogenesis 2019 Mar 12;40(1):2-14. doi: 10.1093/carcin/bgy171. PMID: 30475990Free PMC Article
High-level Sp1 is Associated with Proliferation, Invasion, and Poor Prognosis in Astrocytoma.
Chen YT, Tsai HP, Wu CC, Chen CY, Chai CY, Kwan AL
Pathol Oncol Res 2019 Jul;25(3):1003-1013. Epub 2018 Jun 9 doi: 10.1007/s12253-018-0422-8. PMID: 29948615
Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.
Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi MA, McFarlane N, Subapanditha M, Nolte SM, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, Provias JP, Reddy K, Murty NK, Doble BW, Bhatia M, Hassell JA, Singh SK
Clin Cancer Res 2015 Dec 1;21(23):5324-37. Epub 2015 Jul 7 doi: 10.1158/1078-0432.CCR-14-3147. PMID: 26152745
The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms.
Loew S, Schmidt U, Unterberg A, Halatsch ME
Anticancer Agents Med Chem 2009 Jul;9(6):703-15. doi: 10.2174/187152009788680019. PMID: 19601750
Gefitinib (Iressa, ZD1839) and tyrosine kinase inhibitors: the wave of the future in cancer therapy.
Penne K, Bohlin C, Schneider S, Allen D
Cancer Nurs 2005 Nov-Dec;28(6):481-6. doi: 10.1097/00002820-200511000-00012. PMID: 16330971

Clinical prediction guides

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells.
Moujalled D, Southon AG, Saleh E, Brinkmann K, Ke F, Iliopoulos M, Cross RS, Jenkins MR, Nhu D, Wang Z, Shi MX, Kluck RM, Lessene G, Grabow S, Bush AI, Strasser A
Cell Death Differ 2022 Jul;29(7):1335-1348. Epub 2022 Mar 24 doi: 10.1038/s41418-022-00977-2. PMID: 35332309Free PMC Article
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.
Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG
Genome Res 2015 Mar;25(3):316-27. Epub 2015 Feb 3 doi: 10.1101/gr.180612.114. PMID: 25650244Free PMC Article
The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms.
Loew S, Schmidt U, Unterberg A, Halatsch ME
Anticancer Agents Med Chem 2009 Jul;9(6):703-15. doi: 10.2174/187152009788680019. PMID: 19601750
In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines.
Avramis IA, Christodoulopoulos G, Suzuki A, Laug WE, Gonzalez-Gomez I, McNamara G, Sausville EA, Avramis VI
Cancer Chemother Pharmacol 2002 Dec;50(6):479-89. Epub 2002 Oct 17 doi: 10.1007/s00280-002-0507-6. PMID: 12451475
Effect of ionizing radiation on partial seizures attributable to malignant cerebral tumors.
Chalifoux R, Elisevich K
Stereotact Funct Neurosurg 1996-1997;67(3-4):169-82. doi: 10.1159/000099446. PMID: 9311074

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