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KRAS Gene Rearrangement

MedGen UID:
1709180
•Concept ID:
C5238913
•
Cell or Molecular Dysfunction
Synonyms: c-K-ras Gene Rearrangement; KRAS Rearrangement; KRAS-2 Gene Rearrangement; KRAS2 Gene Rearrangement; v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the KRAS gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKRAS Gene Rearrangement

Professional guidelines

PubMed

Practical considerations in screening for genetic alterations in cholangiocarcinoma.
Bekaii-Saab TS, Bridgewater J, Normanno N
Ann Oncol 2021 Sep;32(9):1111-1126. Epub 2021 Apr 28 doi: 10.1016/j.annonc.2021.04.012. PMID: 33932504
Recent progress in systemic treatment for lung cancer.
Clark JW, Longo DL
Curr Opin Pulm Med 2018 Jul;24(4):355-366. doi: 10.1097/MCP.0000000000000493. PMID: 29697418
Diagnosis and management of differentiated thyroid cancer using molecular biology.
Witt RL, Ferris RL, Pribitkin EA, Sherman SI, Steward DL, Nikiforov YE
Laryngoscope 2013 Apr;123(4):1059-64. Epub 2013 Feb 12 doi: 10.1002/lary.23838. PMID: 23404751

Recent clinical studies

Therapy

Transformation of primate cells by chemicals and oncogenes: requirements for multiple factors.
Khoobyarian N, Marczynska B
Anticancer Res 1989 Sep-Oct;9(5):1367-76. PMID: 2556070

Supplemental Content

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