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Renal interstitial deposits

MedGen UID:
1709193
•Concept ID:
C5397661
•
Finding
HPO: HP:0032644

Definition

Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney. [from HPO]

Professional guidelines

PubMed

A nomogram prediction model for treatment failure in primary membranous nephropathy.
Geng C, Huang L, Li Q, Li G, Li Y, Zhang P, Feng Y
Ren Fail 2023;45(2):2265159. Epub 2023 Oct 5 doi: 10.1080/0886022X.2023.2265159. PMID: 37795790Free PMC Article
Rituximab for the Treatment of IgG4-Related Tubulointerstitial Nephritis: Case Report and Review of the Literature.
McMahon BA, Novick T, Scheel PJ, Bagnasco S, Atta MG
Medicine (Baltimore) 2015 Aug;94(32):e1366. doi: 10.1097/MD.0000000000001366. PMID: 26266393Free PMC Article
Diagnosis and management of gout.
Pittman JR, Bross MH
Am Fam Physician 1999 Apr 1;59(7):1799-806, 1810. PMID: 10208700

Recent clinical studies

Etiology

Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
Idiopathic hypercalciuria and formation of calcium renal stones.
Coe FL, Worcester EM, Evan AP
Nat Rev Nephrol 2016 Sep;12(9):519-33. Epub 2016 Jul 25 doi: 10.1038/nrneph.2016.101. PMID: 27452364Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Renal complications of Fabry disease.
Basic-Jukic N, Kes P, Coric M, Basic-Kes V
Curr Pharm Des 2013;19(33):6046-50. doi: 10.2174/13816128113199990346. PMID: 23448456
Hyperuricemia and gout.
German DC, Holmes EW
Med Clin North Am 1986 Mar;70(2):419-36. doi: 10.1016/s0025-7125(16)30961-0. PMID: 3512932

Diagnosis

Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis.
Kmochová T, Kidd KO, Orr A, Hnízda A, Hartmannová H, Hodaňová K, Vyleťal P, Naušová K, Brinsa V, Trešlová H, Sovová J, Barešová V, Svojšová K, Vrbacká A, Stránecký V, Robins VC, Taylor A, Martin L, Rivas-Chavez A, Payne R, Bleyer HA, Williams A, Rennke HG, Weins A, Short PJ, Agrawal V, Storsley LJ, Waikar SS, McPhail ED, Dasari S, Leung N, Hewlett T, Yorke J, Gaston D, Geldenhuys L, Samuels M, Levine AP, West M, Hůlková H, Pompach P, Novák P, Weinberg RB, Bedard K, Živná M, Sikora J, Bleyer AJ Sr, Kmoch S
Kidney Int 2024 Apr;105(4):799-811. Epub 2023 Dec 12 doi: 10.1016/j.kint.2023.11.021. PMID: 38096951
Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
Hyperuricemia and gout.
German DC, Holmes EW
Med Clin North Am 1986 Mar;70(2):419-36. doi: 10.1016/s0025-7125(16)30961-0. PMID: 3512932

Therapy

Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
Li R, Guo Y, Zhang Y, Zhang X, Zhu L, Yan T
Int J Mol Sci 2019 Mar 4;20(5) doi: 10.3390/ijms20051103. PMID: 30836660Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
Hyperuricemia and gout.
German DC, Holmes EW
Med Clin North Am 1986 Mar;70(2):419-36. doi: 10.1016/s0025-7125(16)30961-0. PMID: 3512932

Prognosis

Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis.
Kmochová T, Kidd KO, Orr A, Hnízda A, Hartmannová H, Hodaňová K, Vyleťal P, Naušová K, Brinsa V, Trešlová H, Sovová J, Barešová V, Svojšová K, Vrbacká A, Stránecký V, Robins VC, Taylor A, Martin L, Rivas-Chavez A, Payne R, Bleyer HA, Williams A, Rennke HG, Weins A, Short PJ, Agrawal V, Storsley LJ, Waikar SS, McPhail ED, Dasari S, Leung N, Hewlett T, Yorke J, Gaston D, Geldenhuys L, Samuels M, Levine AP, West M, Hůlková H, Pompach P, Novák P, Weinberg RB, Bedard K, Živná M, Sikora J, Bleyer AJ Sr, Kmoch S
Kidney Int 2024 Apr;105(4):799-811. Epub 2023 Dec 12 doi: 10.1016/j.kint.2023.11.021. PMID: 38096951
IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis.
Wang Z, Ni X, Zhu S, Yue S
Am J Med Sci 2020 Sep;360(3):287-292. Epub 2020 Apr 17 doi: 10.1016/j.amjms.2020.04.010. PMID: 32387117
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
Diagnostic criteria of antibody-mediated rejection in kidney transplants.
Mosquera Reboredo JM, Vázquez Martul E
Nefrologia 2011;31(4):382-91. doi: 10.3265/Nefrologia.pre2011.Apr.10740. PMID: 21738242

Clinical prediction guides

Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis.
Kmochová T, Kidd KO, Orr A, Hnízda A, Hartmannová H, Hodaňová K, Vyleťal P, Naušová K, Brinsa V, Trešlová H, Sovová J, Barešová V, Svojšová K, Vrbacká A, Stránecký V, Robins VC, Taylor A, Martin L, Rivas-Chavez A, Payne R, Bleyer HA, Williams A, Rennke HG, Weins A, Short PJ, Agrawal V, Storsley LJ, Waikar SS, McPhail ED, Dasari S, Leung N, Hewlett T, Yorke J, Gaston D, Geldenhuys L, Samuels M, Levine AP, West M, Hůlková H, Pompach P, Novák P, Weinberg RB, Bedard K, Živná M, Sikora J, Bleyer AJ Sr, Kmoch S
Kidney Int 2024 Apr;105(4):799-811. Epub 2023 Dec 12 doi: 10.1016/j.kint.2023.11.021. PMID: 38096951
Extraglomerular immune complex deposition in lupus nephritis.
Papa V, Brainer J, Henriksen KJ, Cenacchi G, Chang A
Lupus 2022 Jan;31(1):19-27. Epub 2021 Dec 15 doi: 10.1177/09612033211062535. PMID: 34911399
Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
Familial hyperuricemic nephropathy.
Reiter L, Brown MA, Edmonds J
Am J Kidney Dis 1995 Feb;25(2):235-41. doi: 10.1016/0272-6386(95)90004-7. PMID: 7847350

Recent systematic reviews

Biopsy-proven kidney involvement in hypocomplementemic urticarial vasculitis.
Corthier A, Jachiet M, Bertin D, Servais A, Barbet C, Bigot A, Doutre MS, Bessis D, Bouffandeau A, Moranne O, Jarrot PA, Bardin N, Terrier B, Burtey S, Puéchal X, Daniel L, Jourde-Chiche N
BMC Nephrol 2022 Feb 16;23(1):67. doi: 10.1186/s12882-022-02689-8. PMID: 35172758Free PMC Article
Renal lithiasis and inflammatory bowel diseases, an update on pediatric population.
Bianchi L, Gaiani F, Bizzarri B, Minelli R, Cortegoso Valdivia P, Leandro G, Di Mario F, De' Angelis GL, Ruberto C
Acta Biomed 2018 Dec 17;89(9-S):76-80. doi: 10.23750/abm.v89i9-S.7908. PMID: 30561398Free PMC Article

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