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Signet Ring Cell/Histiocytoid Carcinoma

MedGen UID:
1709314
•Concept ID:
C5238498
•
Neoplastic Process
Synonyms: Signet-Ring Cell/Histiocytoid Carcinoma; Signet=Ring Cell/Histiocytoid Carcinoma

Definition

A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignet Ring Cell/Histiocytoid Carcinoma

Recent clinical studies

Diagnosis

Primary Adnexal Signet-Ring Cell/Histiocytoid Carcinoma.
Stewart S, Houghton J, Kamalarajah S, Curragh D
Ophthalmic Plast Reconstr Surg 2021 Jul-Aug 01;37(4):e134-e136. doi: 10.1097/IOP.0000000000001909. PMID: 33315842
Signet-ring cell/histiocytoid carcinoma in the axilla: A case report with genetic analysis using next-generation sequencing.
Ito Y, Ishida M, Ohe C, Miyasaka C, Tsuta K
J Cutan Pathol 2021 Jan;48(1):102-105. Epub 2020 Sep 30 doi: 10.1111/cup.13838. PMID: 32770562
Molecular profiling of a primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid.
Raghavan SS, Clark M, Louie CY, Jensen KC, Dietrich B, Beadle BM, El-Sawy T, Baik F, Kunder CA, Brown RA
J Cutan Pathol 2020 Sep;47(9):860-864. Epub 2020 Jun 15 doi: 10.1111/cup.13733. PMID: 32358805
Signet-ring cell/histiocytoid carcinoma of the eyelid: a case report and review of the literature.
Tanboon J, Uiprasertkul M, Luemsamran P
Am J Dermatopathol 2013 Feb;35(1):e1-5. doi: 10.1097/DAD.0b013e318264991c. PMID: 22885554
Primary signet-ring cell/histiocytoid carcinoma of the eyelid: a clinicopathologic study of 5 cases and review of the literature.
Requena L, Prieto VG, Requena C, Sarasa JL, Manzano R, Seco M, Rütten A, Kazakov DV, Cerroni L, Kutzner H
Am J Surg Pathol 2011 Mar;35(3):378-91. doi: 10.1097/PAS.0b013e318209cac7. PMID: 21317710

Therapy

Molecular profiling of a primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid.
Raghavan SS, Clark M, Louie CY, Jensen KC, Dietrich B, Beadle BM, El-Sawy T, Baik F, Kunder CA, Brown RA
J Cutan Pathol 2020 Sep;47(9):860-864. Epub 2020 Jun 15 doi: 10.1111/cup.13733. PMID: 32358805

Prognosis

Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid: A "Binocle" Presentation of the "Monocle Tumor".
Bernárdez C, Macías Del Toro E, Ramírez Bellver JL, Martinez Menchón T, Martinez Barba E, Molina-Ruiz AM, Requena L
Am J Dermatopathol 2016 Aug;38(8):623-7. doi: 10.1097/DAD.0000000000000564. PMID: 27391452
Signet-ring cell/histiocytoid carcinoma of the eyelid: a case report and review of the literature.
Tanboon J, Uiprasertkul M, Luemsamran P
Am J Dermatopathol 2013 Feb;35(1):e1-5. doi: 10.1097/DAD.0b013e318264991c. PMID: 22885554

Clinical prediction guides

Signet-ring cell/histiocytoid carcinoma in the axilla: A case report with genetic analysis using next-generation sequencing.
Ito Y, Ishida M, Ohe C, Miyasaka C, Tsuta K
J Cutan Pathol 2021 Jan;48(1):102-105. Epub 2020 Sep 30 doi: 10.1111/cup.13838. PMID: 32770562
Signet-ring cell/histiocytoid carcinoma of the eyelid: a case report and review of the literature.
Tanboon J, Uiprasertkul M, Luemsamran P
Am J Dermatopathol 2013 Feb;35(1):e1-5. doi: 10.1097/DAD.0b013e318264991c. PMID: 22885554
A case of primary signet-ring cell/histiocytoid carcinoma of the eyelid: immunohistochemical comparison with the normal sweat gland and review of the literature.
Iwaya M, Uehara T, Yoshizawa A, Kobayashi Y, Momose M, Honda T, Ota H
Am J Dermatopathol 2012 Dec;34(8):e139-45. doi: 10.1097/DAD.0b013e3182590ec1. PMID: 22935888

Recent systematic reviews

Signet-Ring Cell/Histiocytoid Carcinoma: Report of Two Cases and Systematic Review of the Literature on the Epidemiology, Clinical Characteristics, and Pathological and Molecular Findings.
Michalek IM, Caetano Dos Santos FL, Zwolinski J, Olszewski W, Gałazka A, Prochorec-Sobieszek M, Durzynska M
Am J Dermatopathol 2023 Sep 1;45(9):626-630. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002495. PMID: 37506279

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