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Grade 3b Follicular Lymphoma

MedGen UID:
1709353
•Concept ID:
C3647833
•
Neoplastic Process
Synonyms: Follicular Lymphoma Grade 3b; Follicular lymphoma grade 3b; Follicular lymphoma grade IIIb; Follicular non-Hodgkin lymphoma grade 3b
SNOMED CT: Follicular lymphoma grade 3b (1155957006); Follicular lymphoma grade IIIb (1155957006); Follicular lymphoma grade 3b (1148845007); Follicular lymphoma grade IIIb (1148845007); Follicular non-Hodgkin lymphoma grade 3b (1148845007)

Definition

A grade 3 follicular lymphoma composed of solid sheets of centroblasts. [from NCI]

Professional guidelines

PubMed

Lisocabtagene maraleucel in the treatment of relapsed/refractory large B-cell lymphoma.
St-Pierre F, Gordon LI
Future Oncol 2023 Jan;19(1):19-28. Epub 2023 Jan 18 doi: 10.2217/fon-2022-0774. PMID: 36651471
A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group.
Pardal E, Díez Baeza E, Salas Q, García T, Sancho JM, Monzón E, Moraleda JM, Córdoba R, de la Cruz F, Queizán JA, Rodríguez MJ, Navarro B, Hernández JA, Díez R, Vahi M, Viguria MC, Canales M, Peñarrubia MJ, González-López TJ, Montes-Moreno S, González-Barca E, Caballero D, Martín A; GELTAMO Spanish Collaborative Group
Am J Hematol 2018 Jul;93(7):867-873. Epub 2018 May 6 doi: 10.1002/ajh.25107. PMID: 29658143

Recent clinical studies

Etiology

Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance.
Barraclough A, England JT, Villa D, Wight J, Hapgood G, Conn J, Doo NW, Li EW, Gilbertson M, Shaw B, Bishton MJ, Saeed M, Ratnasingam S, Abeyakoon C, Chong G, Wai SH, Ku M, Lee HP, Fleming K, Tam C, Douglas G, Cheah CY, Ng ZY, Rolfe T, Mills AK, Hamad N, Cashman H, Gleeson M, Narayana M, Hawkes EA
Haematologica 2023 Sep 1;108(9):2444-2453. doi: 10.3324/haematol.2022.281375. PMID: 36815381Free PMC Article
Risk of a second cancer and infection in patients with indolent B-cell lymphoma exposed to first-line bendamustine plus rituximab: A retrospective analysis of an administrative claims database.
Dote S, Inose R, Goto R, Kobayashi Y, Muraki Y
Hematol Oncol 2023 Aug;41(3):354-362. Epub 2023 Feb 21 doi: 10.1002/hon.3128. PMID: 36792059
A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.
Phillips T, Barr PM, Park SI, Kolibaba K, Caimi PF, Chhabra S, Kingsley EC, Boyd T, Chen R, Carret AS, Gartner EM, Li H, Yu C, Smith DC
Invest New Drugs 2019 Apr;37(2):297-306. Epub 2018 Aug 22 doi: 10.1007/s10637-018-0655-0. PMID: 30132271Free PMC Article
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times.
Wahlin BE, Yri OE, Kimby E, Holte H, Delabie J, Smeland EB, Sundström C, Christensson B, Sander B
Br J Haematol 2012 Jan;156(2):225-33. Epub 2011 Nov 30 doi: 10.1111/j.1365-2141.2011.08942.x. PMID: 22126847
Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive.
Bosga-Bouwer AG, van Imhoff GW, Boonstra R, van der Veen A, Haralambieva E, van den Berg A, de Jong B, Krause V, Palmer MC, Coupland R, Kluin PM, van den Berg E, Poppema S
Blood 2003 Feb 1;101(3):1149-54. doi: 10.1182/blood.V101.3.1149. PMID: 12529293

Diagnosis

Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance.
Barraclough A, England JT, Villa D, Wight J, Hapgood G, Conn J, Doo NW, Li EW, Gilbertson M, Shaw B, Bishton MJ, Saeed M, Ratnasingam S, Abeyakoon C, Chong G, Wai SH, Ku M, Lee HP, Fleming K, Tam C, Douglas G, Cheah CY, Ng ZY, Rolfe T, Mills AK, Hamad N, Cashman H, Gleeson M, Narayana M, Hawkes EA
Haematologica 2023 Sep 1;108(9):2444-2453. doi: 10.3324/haematol.2022.281375. PMID: 36815381Free PMC Article
Risk of a second cancer and infection in patients with indolent B-cell lymphoma exposed to first-line bendamustine plus rituximab: A retrospective analysis of an administrative claims database.
Dote S, Inose R, Goto R, Kobayashi Y, Muraki Y
Hematol Oncol 2023 Aug;41(3):354-362. Epub 2023 Feb 21 doi: 10.1002/hon.3128. PMID: 36792059
The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma.
Barraclough A, Bishton M, Cheah CY, Villa D, Hawkes EA
Br J Haematol 2021 Oct;195(1):15-24. Epub 2021 Mar 11 doi: 10.1111/bjh.17404. PMID: 33704790
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times.
Wahlin BE, Yri OE, Kimby E, Holte H, Delabie J, Smeland EB, Sundström C, Christensson B, Sander B
Br J Haematol 2012 Jan;156(2):225-33. Epub 2011 Nov 30 doi: 10.1111/j.1365-2141.2011.08942.x. PMID: 22126847
t(14;18)-negative follicular lymphomas are associated with a high frequency of BCL6 rearrangement at the alternative breakpoint region.
Gu K, Fu K, Jain S, Liu Z, Iqbal J, Li M, Sanger WG, Weisenburger DD, Greiner TC, Aoun P, Dave BJ, Chan WC
Mod Pathol 2009 Sep;22(9):1251-7. Epub 2009 May 22 doi: 10.1038/modpathol.2009.81. PMID: 19465899Free PMC Article

Therapy

Risk of a second cancer and infection in patients with indolent B-cell lymphoma exposed to first-line bendamustine plus rituximab: A retrospective analysis of an administrative claims database.
Dote S, Inose R, Goto R, Kobayashi Y, Muraki Y
Hematol Oncol 2023 Aug;41(3):354-362. Epub 2023 Feb 21 doi: 10.1002/hon.3128. PMID: 36792059
The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma.
Barraclough A, Bishton M, Cheah CY, Villa D, Hawkes EA
Br J Haematol 2021 Oct;195(1):15-24. Epub 2021 Mar 11 doi: 10.1111/bjh.17404. PMID: 33704790
A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.
Phillips T, Barr PM, Park SI, Kolibaba K, Caimi PF, Chhabra S, Kingsley EC, Boyd T, Chen R, Carret AS, Gartner EM, Li H, Yu C, Smith DC
Invest New Drugs 2019 Apr;37(2):297-306. Epub 2018 Aug 22 doi: 10.1007/s10637-018-0655-0. PMID: 30132271Free PMC Article
A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group.
Pardal E, Díez Baeza E, Salas Q, García T, Sancho JM, Monzón E, Moraleda JM, Córdoba R, de la Cruz F, Queizán JA, Rodríguez MJ, Navarro B, Hernández JA, Díez R, Vahi M, Viguria MC, Canales M, Peñarrubia MJ, González-López TJ, Montes-Moreno S, González-Barca E, Caballero D, Martín A; GELTAMO Spanish Collaborative Group
Am J Hematol 2018 Jul;93(7):867-873. Epub 2018 May 6 doi: 10.1002/ajh.25107. PMID: 29658143
Combination of rituximab and nonpegylated liposomal doxorubicin (R-NPLD) as front-line therapy for aggressive non-Hodgkin lymphoma (NHL) in patients 80 years of age or older: a single-center retrospective study.
Ricciuti G, Finolezzi E, Luciani S, Ranucci E, Federico M, Di Nicola M, Zecca IAL, Angrilli F
Hematol Oncol 2018 Feb;36(1):44-48. Epub 2017 Feb 3 doi: 10.1002/hon.2386. PMID: 28156055

Prognosis

Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance.
Barraclough A, England JT, Villa D, Wight J, Hapgood G, Conn J, Doo NW, Li EW, Gilbertson M, Shaw B, Bishton MJ, Saeed M, Ratnasingam S, Abeyakoon C, Chong G, Wai SH, Ku M, Lee HP, Fleming K, Tam C, Douglas G, Cheah CY, Ng ZY, Rolfe T, Mills AK, Hamad N, Cashman H, Gleeson M, Narayana M, Hawkes EA
Haematologica 2023 Sep 1;108(9):2444-2453. doi: 10.3324/haematol.2022.281375. PMID: 36815381Free PMC Article
The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma.
Barraclough A, Bishton M, Cheah CY, Villa D, Hawkes EA
Br J Haematol 2021 Oct;195(1):15-24. Epub 2021 Mar 11 doi: 10.1111/bjh.17404. PMID: 33704790
A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.
Phillips T, Barr PM, Park SI, Kolibaba K, Caimi PF, Chhabra S, Kingsley EC, Boyd T, Chen R, Carret AS, Gartner EM, Li H, Yu C, Smith DC
Invest New Drugs 2019 Apr;37(2):297-306. Epub 2018 Aug 22 doi: 10.1007/s10637-018-0655-0. PMID: 30132271Free PMC Article
A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group.
Pardal E, Díez Baeza E, Salas Q, García T, Sancho JM, Monzón E, Moraleda JM, Córdoba R, de la Cruz F, Queizán JA, Rodríguez MJ, Navarro B, Hernández JA, Díez R, Vahi M, Viguria MC, Canales M, Peñarrubia MJ, González-López TJ, Montes-Moreno S, González-Barca E, Caballero D, Martín A; GELTAMO Spanish Collaborative Group
Am J Hematol 2018 Jul;93(7):867-873. Epub 2018 May 6 doi: 10.1002/ajh.25107. PMID: 29658143
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times.
Wahlin BE, Yri OE, Kimby E, Holte H, Delabie J, Smeland EB, Sundström C, Christensson B, Sander B
Br J Haematol 2012 Jan;156(2):225-33. Epub 2011 Nov 30 doi: 10.1111/j.1365-2141.2011.08942.x. PMID: 22126847

Clinical prediction guides

A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.
Phillips T, Barr PM, Park SI, Kolibaba K, Caimi PF, Chhabra S, Kingsley EC, Boyd T, Chen R, Carret AS, Gartner EM, Li H, Yu C, Smith DC
Invest New Drugs 2019 Apr;37(2):297-306. Epub 2018 Aug 22 doi: 10.1007/s10637-018-0655-0. PMID: 30132271Free PMC Article
A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group.
Pardal E, Díez Baeza E, Salas Q, García T, Sancho JM, Monzón E, Moraleda JM, Córdoba R, de la Cruz F, Queizán JA, Rodríguez MJ, Navarro B, Hernández JA, Díez R, Vahi M, Viguria MC, Canales M, Peñarrubia MJ, González-López TJ, Montes-Moreno S, González-Barca E, Caballero D, Martín A; GELTAMO Spanish Collaborative Group
Am J Hematol 2018 Jul;93(7):867-873. Epub 2018 May 6 doi: 10.1002/ajh.25107. PMID: 29658143
Impact of prior rituximab on outcomes of autologous stem-cell transplantation in patients with relapsed or refractory aggressive B-cell lymphoma: a multicentre retrospective Spanish group of lymphoma/autologous bone marrow transplant study.
Redondo AM, Pomares H, Vidal MJ, Pascual MJ, Quereda B, Sancho JM, Polo M, López J, Conde E, Jarque I, Alonso N, Ramírez MJ, Fernández P, Sayas MJ, Requena MJ, Salar A, González JD, González-Barca E, Arranz R, Caballero D, Martín A
Br J Haematol 2014 Mar;164(5):668-74. Epub 2013 Nov 26 doi: 10.1111/bjh.12676. PMID: 24274082

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