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Focal motor seizure with dystonia

MedGen UID:
1709514
•Concept ID:
C5397728
•
Disease or Syndrome
HPO: HP:0032718

Definition

A focal motor seizure in which the initial semiological manifestation is the sustained contraction of both agonist and antagonist muscles producing athetoid or twisting movements, which produces abnormal postures. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal motor seizure with dystonia

Professional guidelines

PubMed

Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Effects of antiepileptic treatment on sleep and seizures in nocturnal frontal lobe epilepsy.
De Paolis F, Colizzi E, Milioli G, Grassi A, Riccardi S, Puligheddu M, Terzano MG, Marrosu F, Parrino L
Sleep Med 2013 Jul;14(7):597-604. Epub 2013 Jun 7 doi: 10.1016/j.sleep.2013.02.014. PMID: 23746822

Recent clinical studies

Etiology

Long-term seizure outcomes in patients with anti-Leucine-rich glioma-inactivated 1 encephalitis.
Lin N, Liu Q, Chen J, Jin L, Huang Y, Lu Q, Guan H
Epilepsy Behav 2021 Sep;122:108159. Epub 2021 Jul 3 doi: 10.1016/j.yebeh.2021.108159. PMID: 34229158
Movement disorders phenomenology in focal motor seizures.
Fasano A, Di Bonaventura C, Bove F, Espay AJ, Morgante F, Fabbrini G, Munhoz RP, Andrade D, Borlot F, Bui E, Di Gennaro G, Iorio R, Katzberg H, Luigetti M, Striano P, Defazio G, Berardelli A
Parkinsonism Relat Disord 2019 Apr;61:161-165. Epub 2018 Oct 16 doi: 10.1016/j.parkreldis.2018.10.021. PMID: 30361137
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Olanzapine-related repetitive focal seizures with lingual dystonia.
Anzellotti F, Capasso M, Frazzini V, Onofrj M
Epileptic Disord 2016 Mar;18(1):83-6. doi: 10.1684/epd.2016.0805. PMID: 26898965
Ictal motor sequences: Lateralization and localization values.
Marashly A, Ewida A, Agarwal R, Younes K, Lüders HO
Epilepsia 2016 Mar;57(3):369-75. Epub 2016 Feb 11 doi: 10.1111/epi.13322. PMID: 26864781

Diagnosis

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Movement disorders phenomenology in focal motor seizures.
Fasano A, Di Bonaventura C, Bove F, Espay AJ, Morgante F, Fabbrini G, Munhoz RP, Andrade D, Borlot F, Bui E, Di Gennaro G, Iorio R, Katzberg H, Luigetti M, Striano P, Defazio G, Berardelli A
Parkinsonism Relat Disord 2019 Apr;61:161-165. Epub 2018 Oct 16 doi: 10.1016/j.parkreldis.2018.10.021. PMID: 30361137
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
From nocturnal frontal lobe epilepsy to Sleep-Related Hypermotor Epilepsy: A 35-year diagnostic challenge.
Tinuper P, Bisulli F
Seizure 2017 Jan;44:87-92. Epub 2016 Dec 15 doi: 10.1016/j.seizure.2016.11.023. PMID: 28027860
MTLE with hippocampal sclerosis in adult as a syndrome.
Baulac M
Rev Neurol (Paris) 2015 Mar;171(3):259-66. Epub 2015 Feb 26 doi: 10.1016/j.neurol.2015.02.004. PMID: 25727907

Therapy

Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Olanzapine-related repetitive focal seizures with lingual dystonia.
Anzellotti F, Capasso M, Frazzini V, Onofrj M
Epileptic Disord 2016 Mar;18(1):83-6. doi: 10.1684/epd.2016.0805. PMID: 26898965
Infantile epileptic syndromes and metabolic etiologies.
Vigevano F, Bartuli A
J Child Neurol 2002 Dec;17 Suppl 3:3S9-13; discussion 3S14. PMID: 12597051
Exercise induced steroid dependent dystonia, ataxia, and alternating hemiplegia associated with epilepsy.
Neville BG, Besag FM, Marsden CD
J Neurol Neurosurg Psychiatry 1998 Aug;65(2):241-4. doi: 10.1136/jnnp.65.2.241. PMID: 9703179Free PMC Article

Prognosis

Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Ictal motor sequences: Lateralization and localization values.
Marashly A, Ewida A, Agarwal R, Younes K, Lüders HO
Epilepsia 2016 Mar;57(3):369-75. Epub 2016 Feb 11 doi: 10.1111/epi.13322. PMID: 26864781
MTLE with hippocampal sclerosis in adult as a syndrome.
Baulac M
Rev Neurol (Paris) 2015 Mar;171(3):259-66. Epub 2015 Feb 26 doi: 10.1016/j.neurol.2015.02.004. PMID: 25727907
The phenotypic spectrum of SCN8A encephalopathy.
Larsen J, Carvill GL, Gardella E, Kluger G, Schmiedel G, Barisic N, Depienne C, Brilstra E, Mang Y, Nielsen JE, Kirkpatrick M, Goudie D, Goldman R, Jähn JA, Jepsen B, Gill D, Döcker M, Biskup S, McMahon JM, Koeleman B, Harris M, Braun K, de Kovel CG, Marini C, Specchio N, Djémié T, Weckhuysen S, Tommerup N, Troncoso M, Troncoso L, Bevot A, Wolff M, Hjalgrim H, Guerrini R, Scheffer IE, Mefford HC, Møller RS; EuroEPINOMICS RES Consortium CRP
Neurology 2015 Feb 3;84(5):480-9. Epub 2015 Jan 7 doi: 10.1212/WNL.0000000000001211. PMID: 25568300Free PMC Article

Clinical prediction guides

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Automated video analysis of emotion and dystonia in epileptic seizures.
Hou JC, Thonnat M, Bartolomei F, McGonigal A
Epilepsy Res 2022 Aug;184:106953. Epub 2022 May 28 doi: 10.1016/j.eplepsyres.2022.106953. PMID: 35753205
Myoclonus-dystonia (DYT11, DYT-SGCE) - a channelopathy?
Wictorin K, Puschmann A
Neurol Neurochir Pol 2020;54(1):3-5. doi: 10.5603/PJNNS.a2020.0013. PMID: 32115676
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article

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