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Metastatic Unresectable Pituitary Neuroendocrine Tumor

MedGen UID:
1709938
•Concept ID:
C5235849
•
Neoplastic Process
Synonyms: Unresectable Metastatic PitNET; Unresectable Metastatic Pituitary Neuroendocrine Tumor; Unresectable Pituitary Gland Carcinoma

Definition

Metastatic pituitary neuroendocrine tumor that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Unresectable Pituitary Neuroendocrine Tumor

Recent clinical studies

Etiology

Head-to-Head Comparison of (68)Ga-DOTA-JR11 and (68)Ga-DOTATATE PET/CT in Patients with Metastatic, Well-Differentiated Neuroendocrine Tumors: A Prospective Study.
Zhu W, Cheng Y, Wang X, Yao S, Bai C, Zhao H, Jia R, Xu J, Huo L
J Nucl Med 2020 Jun;61(6):897-903. Epub 2019 Nov 1 doi: 10.2967/jnumed.119.235093. PMID: 31676731Free PMC Article
Dose escalation and pharmacokinetic study of AEZS-108 (AN-152), an LHRH agonist linked to doxorubicin, in women with LHRH receptor-positive tumors.
Emons G, Kaufmann M, Gorchev G, Tsekova V, Gründker C, Günthert AR, Hanker LC, Velikova M, Sindermann H, Engel J, Schally AV
Gynecol Oncol 2010 Dec;119(3):457-61. Epub 2010 Sep 9 doi: 10.1016/j.ygyno.2010.08.003. PMID: 20828803
Biliary manifestation of Erdheim-Chester disease mimicking Klatskin's carcinoma.
Gundling F, Nerlich A, Heitland WU, Schepp W
Am J Gastroenterol 2007 Feb;102(2):452-4. Epub 2006 Oct 13 doi: 10.1111/j.1572-0241.2006.00893.x. PMID: 17037989
Metastatic proclivities and patterns among APUD cell neoplasms.
Moffat FL Jr, Ketcham AS
Semin Surg Oncol 1993 Sep-Oct;9(5):443-52. doi: 10.1002/ssu.2980090512. PMID: 7902611

Diagnosis

Metachronous immune-related adverse events involving type 1 diabetes and isolated adrenocorticotropic hormone deficiency associated with pembrolizumab monotherapy for metastatic head and neck cancer: a case report.
Iijima H, Sakai A, Ebisumoto K, Yamauchi M, Teramura T, Yamazaki A, Inagi T, Okami K
J Med Case Rep 2023 Sep 12;17(1):387. doi: 10.1186/s13256-023-04106-6. PMID: 37697390Free PMC Article
Head-to-Head Comparison of (68)Ga-DOTA-JR11 and (68)Ga-DOTATATE PET/CT in Patients with Metastatic, Well-Differentiated Neuroendocrine Tumors: A Prospective Study.
Zhu W, Cheng Y, Wang X, Yao S, Bai C, Zhao H, Jia R, Xu J, Huo L
J Nucl Med 2020 Jun;61(6):897-903. Epub 2019 Nov 1 doi: 10.2967/jnumed.119.235093. PMID: 31676731Free PMC Article
Nivolumab-induced Adrenal Insufficiency in Patients With Renal Cell Carcinoma.
Suzuki K, Terakawa T, Furukawa J, Harada K, Hinata N, Nakano Y, Fujisawa M
J Immunother 2020 Jan;43(1):38-42. doi: 10.1097/CJI.0000000000000299. PMID: 31567704
Advanced therapeutic strategy for radiation-induced osteosarcoma in the skull base: a case report and review.
Yamada SM, Ishii Y, Yamada S, Kuribayashi S, Kumita S, Matsuno A
Radiat Oncol 2012 Aug 10;7:136. doi: 10.1186/1748-717X-7-136. PMID: 22883312Free PMC Article
Biliary manifestation of Erdheim-Chester disease mimicking Klatskin's carcinoma.
Gundling F, Nerlich A, Heitland WU, Schepp W
Am J Gastroenterol 2007 Feb;102(2):452-4. Epub 2006 Oct 13 doi: 10.1111/j.1572-0241.2006.00893.x. PMID: 17037989

Therapy

Nivolumab-induced Adrenal Insufficiency in Patients With Renal Cell Carcinoma.
Suzuki K, Terakawa T, Furukawa J, Harada K, Hinata N, Nakano Y, Fujisawa M
J Immunother 2020 Jan;43(1):38-42. doi: 10.1097/CJI.0000000000000299. PMID: 31567704
Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma.
Okano Y, Satoh T, Horiguchi K, Toyoda M, Osaki A, Matsumoto S, Tomaru T, Nakajima Y, Ishii S, Ozawa A, Shibusawa N, Shimada T, Higuchi T, Chikamatsu K, Yamada M
Endocr J 2016 Oct 29;63(10):905-912. Epub 2016 Jul 20 doi: 10.1507/endocrj.EJ16-0161. PMID: 27440480
Advanced therapeutic strategy for radiation-induced osteosarcoma in the skull base: a case report and review.
Yamada SM, Ishii Y, Yamada S, Kuribayashi S, Kumita S, Matsuno A
Radiat Oncol 2012 Aug 10;7:136. doi: 10.1186/1748-717X-7-136. PMID: 22883312Free PMC Article
Dose escalation and pharmacokinetic study of AEZS-108 (AN-152), an LHRH agonist linked to doxorubicin, in women with LHRH receptor-positive tumors.
Emons G, Kaufmann M, Gorchev G, Tsekova V, Gründker C, Günthert AR, Hanker LC, Velikova M, Sindermann H, Engel J, Schally AV
Gynecol Oncol 2010 Dec;119(3):457-61. Epub 2010 Sep 9 doi: 10.1016/j.ygyno.2010.08.003. PMID: 20828803
Mifepristone. Auxiliary therapeutic use in cancer and related disorders.
Koide SS
J Reprod Med 1998 Jul;43(7):551-60. PMID: 9693404

Prognosis

Advanced therapeutic strategy for radiation-induced osteosarcoma in the skull base: a case report and review.
Yamada SM, Ishii Y, Yamada S, Kuribayashi S, Kumita S, Matsuno A
Radiat Oncol 2012 Aug 10;7:136. doi: 10.1186/1748-717X-7-136. PMID: 22883312Free PMC Article
Biliary manifestation of Erdheim-Chester disease mimicking Klatskin's carcinoma.
Gundling F, Nerlich A, Heitland WU, Schepp W
Am J Gastroenterol 2007 Feb;102(2):452-4. Epub 2006 Oct 13 doi: 10.1111/j.1572-0241.2006.00893.x. PMID: 17037989
Mifepristone. Auxiliary therapeutic use in cancer and related disorders.
Koide SS
J Reprod Med 1998 Jul;43(7):551-60. PMID: 9693404
Metastatic proclivities and patterns among APUD cell neoplasms.
Moffat FL Jr, Ketcham AS
Semin Surg Oncol 1993 Sep-Oct;9(5):443-52. doi: 10.1002/ssu.2980090512. PMID: 7902611

Clinical prediction guides

Metachronous immune-related adverse events involving type 1 diabetes and isolated adrenocorticotropic hormone deficiency associated with pembrolizumab monotherapy for metastatic head and neck cancer: a case report.
Iijima H, Sakai A, Ebisumoto K, Yamauchi M, Teramura T, Yamazaki A, Inagi T, Okami K
J Med Case Rep 2023 Sep 12;17(1):387. doi: 10.1186/s13256-023-04106-6. PMID: 37697390Free PMC Article
Nivolumab-induced Adrenal Insufficiency in Patients With Renal Cell Carcinoma.
Suzuki K, Terakawa T, Furukawa J, Harada K, Hinata N, Nakano Y, Fujisawa M
J Immunother 2020 Jan;43(1):38-42. doi: 10.1097/CJI.0000000000000299. PMID: 31567704
Dose escalation and pharmacokinetic study of AEZS-108 (AN-152), an LHRH agonist linked to doxorubicin, in women with LHRH receptor-positive tumors.
Emons G, Kaufmann M, Gorchev G, Tsekova V, Gründker C, Günthert AR, Hanker LC, Velikova M, Sindermann H, Engel J, Schally AV
Gynecol Oncol 2010 Dec;119(3):457-61. Epub 2010 Sep 9 doi: 10.1016/j.ygyno.2010.08.003. PMID: 20828803
Biliary manifestation of Erdheim-Chester disease mimicking Klatskin's carcinoma.
Gundling F, Nerlich A, Heitland WU, Schepp W
Am J Gastroenterol 2007 Feb;102(2):452-4. Epub 2006 Oct 13 doi: 10.1111/j.1572-0241.2006.00893.x. PMID: 17037989
Metastatic proclivities and patterns among APUD cell neoplasms.
Moffat FL Jr, Ketcham AS
Semin Surg Oncol 1993 Sep-Oct;9(5):443-52. doi: 10.1002/ssu.2980090512. PMID: 7902611

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