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Sacral Spine Neoplasm

MedGen UID:
1710280
•Concept ID:
C5239035
•
Neoplastic Process

Definition

A benign or malignant neoplasm that affects the sacral region of the spine. [from NCI]

Professional guidelines

PubMed

ACR Appropriateness Criteria® Plexopathy: 2021 Update.
Expert Panel on Neurological and Musculoskeletal Imaging, Boulter DJ, Job J, Shah LM, Wessell DE, Lenchik L, Parsons MS, Agarwal V, Appel M, Burns J, Hutchins TA, Kendi AT, Khan MA, Liebeskind DS, Moritani T, Ortiz AO, Shah VN, Singh S, Than KD, Timpone VM, Beaman FD, Corey AS
J Am Coll Radiol 2021 Nov;18(11S):S423-S441. doi: 10.1016/j.jacr.2021.08.014. PMID: 34794598
Prenatal assessment and management of sacrococcygeal teratoma.
Gucciardo L, Uyttebroek A, De Wever I, Renard M, Claus F, Devlieger R, Lewi L, De Catte L, Deprest J
Prenat Diagn 2011 Jul;31(7):678-88. Epub 2011 Jun 8 doi: 10.1002/pd.2781. PMID: 21656530
Sacral tumors and management.
Varga PP, Bors I, Lazary A
Orthop Clin North Am 2009 Jan;40(1):105-23, vii. doi: 10.1016/j.ocl.2008.09.010. PMID: 19064059

Recent clinical studies

Etiology

Percutaneous Intratumor Laser Ablation for Fetal Sacrococcygeal Teratoma.
Litwińska M, Litwińska E, Janiak K, Piaseczna-Piotrowska A, Szaflik K
Fetal Diagn Ther 2020;47(2):138-144. Epub 2019 Jul 10 doi: 10.1159/000500775. PMID: 31291630
Clinical Monitoring of Sacrococcygeal Teratoma.
Wohlmuth C, Bergh E, Bell C, Johnson A, Moise KJ Jr, van Gemert MJC, van den Wijngaard JPHM, Wohlmuth-Wieser I, Averiss I, Gardiner HM
Fetal Diagn Ther 2019;46(5):333-340. Epub 2019 Mar 20 doi: 10.1159/000496841. PMID: 30893693
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
PELVIS Syndrome.
Girard C, Bigorre M, Guillot B, Bessis D
Arch Dermatol 2006 Jul;142(7):884-8. doi: 10.1001/archderm.142.7.884. PMID: 16847205
Sacrococcygeal teratoma.
Wakhlu A, Misra S, Tandon RK, Wakhlu AK
Pediatr Surg Int 2002 Sep;18(5-6):384-7. Epub 2002 Jun 19 doi: 10.1007/s00383-002-0729-z. PMID: 12415361

Diagnosis

Congenital sacrococcygeal rhabdomyosarcoma.
Inuganti RV, Boddapati A, Mathi A, Shaik R
Afr J Paediatr Surg 2022 Oct-Dec;19(4):251-253. doi: 10.4103/ajps.ajps_69_21. PMID: 36018208Free PMC Article
Sacrococcygeal teratoma.
Mlčochová G, Kučerová L, Rousková B, Rygl M, Prosová B, Matěcha J, Černý M, Hercíková L, Sochůrek J, Fait T
Ceska Gynekol 2019 Winter;84(2):140-144. PMID: 31238684
Coccygeal Polypoid Eccrine Nevus.
Charifa A, Ko CJ
Arch Pathol Lab Med 2019 Jul;143(7):890-892. Epub 2018 Dec 28 doi: 10.5858/arpa.2018-0055-RS. PMID: 30605023
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640

Therapy

Surgical Strategy for Sacral Tumor Resection.
Kim KR, Kim KH, Park JY, Shin DA, Ha Y, Kim KN, Chin DK, Kim KS, Cho YE, Kuh SU
Yonsei Med J 2021 Jan;62(1):59-67. doi: 10.3349/ymj.2021.62.1.59. PMID: 33381935Free PMC Article
The sacral chordoma margin.
Radaelli S, Fossati P, Stacchiotti S, Akiyama T, Asencio JM, Bandiera S, Boglione A, Boland P, Bolle S, Bruland Ø, Brunello A, Bruzzi P, Campanacci D, Cananzi F, Capanna R, Casadei R, Cordoba A, Court C, Dei Tos AP, DeLaney TF, De Paoli A, De Pas TM, Desai A, Di Brina L, Donati DM, Fabbri N, Fiore MR, Frezza A, Gambarotti M, Gasbarrini A, Georg P, Grignani G, Hindi N, Hug EB, Jones R, Kawai A, Krol AD, Le Grange F, Luzzati A, Marquina G, Martin-Benlloch JA, Mazzocco K, Navarria F, Navarria P, Parchi PD, Patel S, Pennacchioli E, Petrongari MG, Picci P, Pollock R, Porcu L, Quagliuolo V, Sangalli C, Scheipl S, Scotto GM, Spalek M, Steinmeier T, Timmermann B, Trama A, Uhl M, Valverde C, Varga PP, Verges R, Weber DC, Zoccali C, Casali PG, Sommer J, Gronchi A
Eur J Surg Oncol 2020 Aug;46(8):1415-1422. Epub 2020 Apr 27 doi: 10.1016/j.ejso.2020.04.028. PMID: 32402509
Percutaneous Intratumor Laser Ablation for Fetal Sacrococcygeal Teratoma.
Litwińska M, Litwińska E, Janiak K, Piaseczna-Piotrowska A, Szaflik K
Fetal Diagn Ther 2020;47(2):138-144. Epub 2019 Jul 10 doi: 10.1159/000500775. PMID: 31291630
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article
Chordoma.
Casali PG, Stacchiotti S, Sangalli C, Olmi P, Gronchi A
Curr Opin Oncol 2007 Jul;19(4):367-70. doi: 10.1097/CCO.0b013e3281214448. PMID: 17545801

Prognosis

Imaging Coccygeal Trauma and Coccydynia.
Skalski MR, Matcuk GR, Patel DB, Tomasian A, White EA, Gross JS
Radiographics 2020 Jul-Aug;40(4):1090-1106. doi: 10.1148/rg.2020190132. PMID: 32609598
Sacrococcygeal teratoma: Nationwide survey and guidelines.
Taguchi T
Pediatr Int 2019 Jul;61(7):633. doi: 10.1111/ped.13933. PMID: 31359538
Neonatal Germ Cell Tumors.
Sandoval JA, Williams RF
Curr Pediatr Rev 2015;11(3):205-15. doi: 10.2174/1573396311666150714105531. PMID: 26168938
Pilonidal sinus disease.
de Parades V, Bouchard D, Janier M, Berger A
J Visc Surg 2013 Sep;150(4):237-47. Epub 2013 Aug 1 doi: 10.1016/j.jviscsurg.2013.05.006. PMID: 23911903
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640

Clinical prediction guides

Surgical Strategy for Sacral Tumor Resection.
Kim KR, Kim KH, Park JY, Shin DA, Ha Y, Kim KN, Chin DK, Kim KS, Cho YE, Kuh SU
Yonsei Med J 2021 Jan;62(1):59-67. doi: 10.3349/ymj.2021.62.1.59. PMID: 33381935Free PMC Article
Imaging Coccygeal Trauma and Coccydynia.
Skalski MR, Matcuk GR, Patel DB, Tomasian A, White EA, Gross JS
Radiographics 2020 Jul-Aug;40(4):1090-1106. doi: 10.1148/rg.2020190132. PMID: 32609598
Clinical Monitoring of Sacrococcygeal Teratoma.
Wohlmuth C, Bergh E, Bell C, Johnson A, Moise KJ Jr, van Gemert MJC, van den Wijngaard JPHM, Wohlmuth-Wieser I, Averiss I, Gardiner HM
Fetal Diagn Ther 2019;46(5):333-340. Epub 2019 Mar 20 doi: 10.1159/000496841. PMID: 30893693
PELVIS Syndrome.
Girard C, Bigorre M, Guillot B, Bessis D
Arch Dermatol 2006 Jul;142(7):884-8. doi: 10.1001/archderm.142.7.884. PMID: 16847205
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Recent systematic reviews

Surgical management of chordoma: A systematic review.
Denaro L, Berton A, Ciuffreda M, Loppini M, Candela V, Brandi ML, Longo UG
J Spinal Cord Med 2020 Nov;43(6):797-812. Epub 2018 Jul 26 doi: 10.1080/10790268.2018.1483593. PMID: 30048230Free PMC Article
Selective Arterial Embolization for the Treatment of Sacral and Pelvic Giant Cell Tumor: A Systematic Review.
He SH, Xu W, Sun ZW, Liu WB, Liu YJ, Wei HF, Xiao JR
Orthop Surg 2017 May;9(2):139-144. doi: 10.1111/os.12336. PMID: 28644557Free PMC Article
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article
A systematic review of clinical outcomes for patients diagnosed with skin cancer spinal metastases.
Goodwin CR, Sankey EW, Liu A, Elder BD, Kosztowski T, Lo SF, Fisher CG, Clarke MJ, Gokaslan ZL, Sciubba DM
J Neurosurg Spine 2016 May;24(5):837-49. Epub 2015 Nov 6 doi: 10.3171/2015.4.SPINE15239. PMID: 26544595
Management of metastatic sacral tumours.
Quraishi NA, Giannoulis KE, Edwards KL, Boszczyk BM
Eur Spine J 2012 Oct;21(10):1984-93. Epub 2012 Jun 23 doi: 10.1007/s00586-012-2394-9. PMID: 22729363Free PMC Article

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