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Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

MedGen UID:
1710338
Concept ID:
C5237208
Neoplastic Process
Synonyms: Skin Carcinosarcoma; Skin Metaplastic Carcinoma; Skin Pseudosarcomatous Squamous Cell Carcinoma; Skin Sarcomatoid Squamous Cell Carcinoma

Definition

A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Squamous Cell Carcinoma with Sarcomatoid Differentiation

Professional guidelines

PubMed

Kanner WA, Brill LB 2nd, Patterson JW, Wick MR
J Cutan Pathol 2010 Jul;37(7):744-50. Epub 2010 Feb 24 doi: 10.1111/j.1600-0560.2010.01534.x. PMID: 20184665

Recent clinical studies

Etiology

Christensen DJ, Tuluc M
J Cutan Pathol 2023 May;50(5):410-414. Epub 2023 Mar 12 doi: 10.1111/cup.14413. PMID: 36794976
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
Vennapusa B, Fischer EG, Wick MR, Cerilli LA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):408-12. doi: 10.1097/PAI.0b013e3182111be5. PMID: 21908981
Wieland CN, Dyck R, Weenig RH, Comfere NI
J Cutan Pathol 2011 Nov;38(11):884-8. Epub 2011 Aug 23 doi: 10.1111/j.1600-0560.2011.01768.x. PMID: 21883368
Wick MR, Fitzgibbon J, Swanson PE
Semin Diagn Pathol 1993 May;10(2):148-58. PMID: 8396271

Diagnosis

Dainese E, Cimetti L, Pozzi B, Milani M, Russo G, Castelnuovo S, Viganò CV, Cerati M, Uccella S, Vanzati A
Pathol Res Pract 2023 Jul;247:154559. Epub 2023 May 19 doi: 10.1016/j.prp.2023.154559. PMID: 37210770
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
Roy SF, Lafaille P, Désy D
Int J Surg Pathol 2019 Aug;27(5):518-520. Epub 2019 Feb 14 doi: 10.1177/1066896919830208. PMID: 30760056
Yu J, Plaza JA, Schieke SM
Am J Dermatopathol 2016 Mar;38(3):e36-9. doi: 10.1097/DAD.0000000000000411. PMID: 26894781
Wick MR, Fitzgibbon J, Swanson PE
Semin Diagn Pathol 1993 May;10(2):148-58. PMID: 8396271

Therapy

Sweeney KJ, Tetzlaff MT, Vega F, Gillenwater A, Zuo Z, Gross N, Nagarajan P, Wargo J, Nelson K, Prieto VG, Torres-Cabala CA, Curry JL
J Cutan Pathol 2021 May;48(5):674-679. Epub 2021 Jan 13 doi: 10.1111/cup.13953. PMID: 33399228
Miller TI, Zoumberos NA, Johnson B, Rhodes DR, Tomlins SA, Chan MP, Andea AA, Lucas DR, McHugh JB, Smith N, Harms KL, Brewer C, Saleh J, Patel RM, Harms PW
Hum Pathol 2020 Aug;102:60-69. Epub 2020 Jun 12 doi: 10.1016/j.humpath.2020.06.003. PMID: 32540221
Radić J, Batinac T, Hadžisejdić I, Načinović-Duletić A, Valković T, Jonjić N
Acta Dermatovenerol Croat 2011;19(3):183-6. PMID: 21933645

Prognosis

Miller TI, Zoumberos NA, Johnson B, Rhodes DR, Tomlins SA, Chan MP, Andea AA, Lucas DR, McHugh JB, Smith N, Harms KL, Brewer C, Saleh J, Patel RM, Harms PW
Hum Pathol 2020 Aug;102:60-69. Epub 2020 Jun 12 doi: 10.1016/j.humpath.2020.06.003. PMID: 32540221
Roy SF, Lafaille P, Désy D
Int J Surg Pathol 2019 Aug;27(5):518-520. Epub 2019 Feb 14 doi: 10.1177/1066896919830208. PMID: 30760056
Yu J, Plaza JA, Schieke SM
Am J Dermatopathol 2016 Mar;38(3):e36-9. doi: 10.1097/DAD.0000000000000411. PMID: 26894781
Nonaka D, Bishop PW
Am J Surg Pathol 2014 Jul;38(7):956-65. doi: 10.1097/PAS.0000000000000210. PMID: 24705313
Velazquez EF, Barreto JE, Rodriguez I, Piris A, Cubilla AL
Int J Surg Pathol 2004 Apr;12(2):139-46. doi: 10.1177/106689690401200207. PMID: 15173919

Clinical prediction guides

Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
Takashima Y, Murakami T, Inoue T, Hagiyama M, Yoneshige A, Nishimura S, Akagi M, Ito A
Tumour Biol 2017 Jun;39(6):1010428317704365. doi: 10.1177/1010428317704365. PMID: 28651491
Cantariño N, Fernández-Figueras MT, Valero V, Musulén E, Malinverni R, Granada I, Goldie SJ, Martín-Caballero J, Douet J, Forcales SV, Buschbeck M
Int J Cancer 2016 Sep 1;139(5):1106-16. Epub 2016 May 5 doi: 10.1002/ijc.30139. PMID: 27074337
Vennapusa B, Fischer EG, Wick MR, Cerilli LA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):408-12. doi: 10.1097/PAI.0b013e3182111be5. PMID: 21908981
Wieland CN, Dyck R, Weenig RH, Comfere NI
J Cutan Pathol 2011 Nov;38(11):884-8. Epub 2011 Aug 23 doi: 10.1111/j.1600-0560.2011.01768.x. PMID: 21883368

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