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Transformed Mycosis Fungoides

MedGen UID:
1710523
•Concept ID:
C5237457
•
Neoplastic Process

Definition

Histologic transformation of mycosis fungoides to an aggressive non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Is immunohistochemical expression of GATA3 helpful in the differential diagnosis of transformed mycosis fungoides and primary cutaneous CD30-positive T cell lymphoproliferative disorders?
Collins K, Gu J, Aung PP, Nagarajan P, Curry JL, Huen A, Ivan D, Prieto VG, Tetzlaff MT, Duvic M, Miranda RN, Vega F, Torres-Cabala CA
Virchows Arch 2021 Aug;479(2):377-383. Epub 2021 Feb 18 doi: 10.1007/s00428-021-03056-y. PMID: 33604757
Effectiveness of brentuximab vedotin before and after allogeneic stem-cell transplantation in the management of transformed mycosis fungoides.
André R, Ram-Wolff C, Battistella M, Peffault de Latour R, Petit A, Bouaziz JD, Brice P, Bagot M, de Masson A
Br J Dermatol 2020 Jun;182(6):1503-1504. Epub 2020 Feb 12 doi: 10.1111/bjd.18806. PMID: 31854457
Clinical roundtable monograph. The management of aggressive T-cell lymphoma: a discussion on transformed mycosis fungoides.
Horwitz SM, Duvic M, Hsi ED
Clin Adv Hematol Oncol 2010 Dec;8(12):1-15. PMID: 21344783

Recent clinical studies

Etiology

Nodal Involvement by CD30(+) Cutaneous Lymphoproliferative Disorders and Its Challenging Differentiation From Classical Hodgkin Lymphoma.
Lezama LS, Gratzinger D
Arch Pathol Lab Med 2018 Jan;142(1):139-142. doi: 10.5858/arpa.2016-0352-RS. PMID: 29257929
Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis.
Vural S, Akay BN, Botsalı A, Atilla E, Parlak N, Okçu Heper A, Şanlı H
Turk J Haematol 2018 Mar 1;35(1):35-41. Epub 2017 May 23 doi: 10.4274/tjh.2016.0502. PMID: 28533196Free PMC Article
Retrospective Analysis of Prognostic Factors in 187 Cases of Transformed Mycosis Fungoides.
Talpur R, Sui D, Gangar P, Dabaja BS, Duvic M
Clin Lymphoma Myeloma Leuk 2016 Jan;16(1):49-56. Epub 2015 Dec 1 doi: 10.1016/j.clml.2015.11.010. PMID: 26702474
Altered microRNA expression in folliculotropic and transformed mycosis fungoides.
Marosvári D, Téglási V, Csala I, Marschalkó M, Bödör C, Timár B, Csomor J, Hársing J, Reiniger L
Pathol Oncol Res 2015 Jul;21(3):821-5. Epub 2015 Feb 20 doi: 10.1007/s12253-015-9897-8. PMID: 25698383
Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases.
Benner MF, Jansen PM, Vermeer MH, Willemze R
Blood 2012 Feb 16;119(7):1643-9. Epub 2011 Dec 12 doi: 10.1182/blood-2011-08-376319. PMID: 22160616

Diagnosis

Differential molecular programs of cutaneous anaplastic large cell lymphoma and CD30-positive transformed mycosis fungoides.
Lai P, Liu F, Liu X, Sun J, Wang Y
Front Immunol 2023;14:1270365. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1270365. PMID: 37790936Free PMC Article
Prognostic Significance of CD30 in Transformed Mycosis Fungoides.
Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436
Nodal Involvement by CD30(+) Cutaneous Lymphoproliferative Disorders and Its Challenging Differentiation From Classical Hodgkin Lymphoma.
Lezama LS, Gratzinger D
Arch Pathol Lab Med 2018 Jan;142(1):139-142. doi: 10.5858/arpa.2016-0352-RS. PMID: 29257929
Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis.
Vural S, Akay BN, Botsalı A, Atilla E, Parlak N, Okçu Heper A, Şanlı H
Turk J Haematol 2018 Mar 1;35(1):35-41. Epub 2017 May 23 doi: 10.4274/tjh.2016.0502. PMID: 28533196Free PMC Article
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):205.e1-16; quiz 221-2. doi: 10.1016/j.jaad.2013.07.049. PMID: 24438969

Therapy

Pooled analysis of pralatrexate single-agent studies in patients with relapsed/refractory peripheral T-cell lymphoma.
O'Connor OA, Ko BS, Wang MC, Maruyama D, Song Y, Yeoh EM, Manamley N, Tobinai K
Blood Adv 2024 Jun 11;8(11):2601-2611. doi: 10.1182/bloodadvances.2023010441. PMID: 38429077Free PMC Article
Disease characteristics, prognosis, and response to therapy in patients with large-cell transformed mycosis fungoides: A single-center retrospective study.
O'Donnell M, Zaya R, Correia E, Krishnasamy S, Sahu J, Shi W, Cha J, Alpdogan SO, Porcu P, Nikbakht N
J Am Acad Dermatol 2022 Jun;86(6):1285-1292. Epub 2021 Jul 14 doi: 10.1016/j.jaad.2021.07.013. PMID: 34273458
Brentuximab vedotin in CD30(+) primary cutaneous T-cell lymphomas: a review and analysis of existing data.
Enos TH, Feigenbaum LS, Wickless HW
Int J Dermatol 2017 Dec;56(12):1400-1405. Epub 2017 Aug 1 doi: 10.1111/ijd.13696. PMID: 28762479
Total skin electron beam and non-myeloablative allogeneic hematopoietic stem-cell transplantation in advanced mycosis fungoides and Sezary syndrome.
Duvic M, Donato M, Dabaja B, Richmond H, Singh L, Wei W, Acholonu S, Khouri I, Champlin R, Hosing C
J Clin Oncol 2010 May 10;28(14):2365-72. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.25.8301. PMID: 20351328
Treatment of transformed mycosis fungoides with intermittent low-dose gemcitabine.
Awar O, Duvic M
Oncology 2007;73(1-2):130-5. Epub 2008 Mar 13 doi: 10.1159/000121002. PMID: 18337626

Prognosis

Prognostic Significance of CD30 in Transformed Mycosis Fungoides.
Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436
Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis.
Vural S, Akay BN, Botsalı A, Atilla E, Parlak N, Okçu Heper A, Şanlı H
Turk J Haematol 2018 Mar 1;35(1):35-41. Epub 2017 May 23 doi: 10.4274/tjh.2016.0502. PMID: 28533196Free PMC Article
Altered microRNA expression in folliculotropic and transformed mycosis fungoides.
Marosvári D, Téglási V, Csala I, Marschalkó M, Bödör C, Timár B, Csomor J, Hársing J, Reiniger L
Pathol Oncol Res 2015 Jul;21(3):821-5. Epub 2015 Feb 20 doi: 10.1007/s12253-015-9897-8. PMID: 25698383
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):205.e1-16; quiz 221-2. doi: 10.1016/j.jaad.2013.07.049. PMID: 24438969
Transformed mycosis fungoides: clinicopathological features and outcome.
Barberio E, Thomas L, Skowron F, Balme B, Dalle S
Br J Dermatol 2007 Aug;157(2):284-9. Epub 2007 Jun 15 doi: 10.1111/j.1365-2133.2007.08008.x. PMID: 17573879

Clinical prediction guides

Role of B-cells in Mycosis Fungoides.
Nielsen PR, Eriksen JO, Sørensen MD, Wehkamp U, Lindahl LM, Bzorek M, Iversen L, Woetman A, Ødum N, Litman T, Gjerdrum LMR
Acta Derm Venereol 2021 Mar 11;101(3):adv00413. doi: 10.2340/00015555-3775. PMID: 33686443Free PMC Article
Is immunohistochemical expression of GATA3 helpful in the differential diagnosis of transformed mycosis fungoides and primary cutaneous CD30-positive T cell lymphoproliferative disorders?
Collins K, Gu J, Aung PP, Nagarajan P, Curry JL, Huen A, Ivan D, Prieto VG, Tetzlaff MT, Duvic M, Miranda RN, Vega F, Torres-Cabala CA
Virchows Arch 2021 Aug;479(2):377-383. Epub 2021 Feb 18 doi: 10.1007/s00428-021-03056-y. PMID: 33604757
Galectin-3 Expression in Primary Cutaneous CD30-Positive Lymphoproliferative Disorders and Transformed Mycosis Fungoides.
Mitteldorf C, Robson A, Tronnier M, Pfaltz MC, Kempf W
Dermatology 2015;231(2):164-70. Epub 2015 Jun 20 doi: 10.1159/000431313. PMID: 26111483
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Karai LJ, Kadin ME, Hsi ED, Sluzevich JC, Ketterling RP, Knudson RA, Feldman AL
Am J Surg Pathol 2013 Aug;37(8):1173-81. doi: 10.1097/PAS.0b013e318282d01e. PMID: 23648461
Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases.
Benner MF, Jansen PM, Vermeer MH, Willemze R
Blood 2012 Feb 16;119(7):1643-9. Epub 2011 Dec 12 doi: 10.1182/blood-2011-08-376319. PMID: 22160616

Recent systematic reviews

Prognostic Significance of CD30 in Transformed Mycosis Fungoides.
Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436

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