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Refractory Skin Squamous Cell Carcinoma

MedGen UID:
1710593
•Concept ID:
C5237413
•
Neoplastic Process

Definition

Skin squamous cell carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Skin Squamous Cell Carcinoma

Professional guidelines

PubMed

Management of partial and non-responding cutaneous squamous cell carcinoma.
Jansen P, Lodde GC, Griewank KG, Hadaschik E, Roesch A, Ugurel S, Zimmer L, Livingstone E, Schadendorf D
J Eur Acad Dermatol Venereol 2022 Jan;36 Suppl 1:29-34. doi: 10.1111/jdv.17404. PMID: 34855242
Medical treatment of advanced cutaneous squamous-cell carcinoma.
Gellrich FF, Hüning S, Beissert S, Eigentler T, Stockfleth E, Gutzmer R, Meier F
J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:38-43. doi: 10.1111/jdv.16024. PMID: 31833610
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Recent clinical studies

Etiology

Two-year follow-up of a randomized phase III clinical trial of nivolumab vs. the investigator's choice of therapy in the Asian population for recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141).
Yen CJ, Kiyota N, Hanai N, Takahashi S, Yokota T, Iwae S, Shimizu Y, Hong RL, Goto M, Kang JH, Li WSK, Ferris RL, Gillison M, Endo T, Jayaprakash V, Tahara M
Head Neck 2020 Oct;42(10):2852-2862. Epub 2020 Jun 24 doi: 10.1002/hed.26331. PMID: 32583557Free PMC Article
Medical treatment of advanced cutaneous squamous-cell carcinoma.
Gellrich FF, Hüning S, Beissert S, Eigentler T, Stockfleth E, Gutzmer R, Meier F
J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:38-43. doi: 10.1111/jdv.16024. PMID: 31833610
Pembrolizumab for recurrent/metastatic head and neck squamous cell carcinoma in an Asian population.
Chen WC, Chu PY, Lee YT, Lu WB, Liu CY, Chang PM, Yang MH
Medicine (Baltimore) 2017 Dec;96(52):e9519. doi: 10.1097/MD.0000000000009519. PMID: 29384959Free PMC Article
Cancers mimicking fungal infections.
Ladizinski B, Alavi A, Jambrosic J, Mistry N, Sibbald RG
Adv Skin Wound Care 2014 Jul;27(7):301-9. doi: 10.1097/01.ASW.0000446864.26807.43. PMID: 24932950
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Diagnosis

m6A modification of mRNA in skin diseases.
Yan Z, Liang P
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Aug 28;47(8):1154-1162. doi: 10.11817/j.issn.1672-7347.2022.210332. PMID: 36097784
Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Cancers mimicking fungal infections.
Ladizinski B, Alavi A, Jambrosic J, Mistry N, Sibbald RG
Adv Skin Wound Care 2014 Jul;27(7):301-9. doi: 10.1097/01.ASW.0000446864.26807.43. PMID: 24932950
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Retinoids as preventive and therapeutic anticancer agents (Part I).
Lippman SM, Kessler JF, Meyskens FL Jr
Cancer Treat Rep 1987 Apr;71(4):391-405. PMID: 3548957

Therapy

Immunotherapy for Non-melanoma Skin Cancer.
Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958Free PMC Article
Pembrolizumab in Patients with Refractory Cutaneous Squamous Cell Carcinoma: A Phase II Trial.
Ferrarotto R, Sousa LG, Qing Y, Kaya D, Stephen B, Jain D, Bell D, Pant S, Tsimberidou AM, Janku F, Blumenschein G, Glisson BS, Ahnert JR, Piha-Paul SA, Lee JJ, Wong MK, Lu C, Meric-Bernstam F, Naing A
Adv Ther 2021 Aug;38(8):4581-4591. Epub 2021 Jul 9 doi: 10.1007/s12325-021-01807-6. PMID: 34241781
Immune checkpoint inhibitors to treat cutaneous malignancies.
Barrios DM, Do MH, Phillips GS, Postow MA, Akaike T, Nghiem P, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1239-1253. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.03.131. PMID: 32461079Free PMC Article
Medical treatment of advanced cutaneous squamous-cell carcinoma.
Gellrich FF, Hüning S, Beissert S, Eigentler T, Stockfleth E, Gutzmer R, Meier F
J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:38-43. doi: 10.1111/jdv.16024. PMID: 31833610
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Prognosis

m6A modification of mRNA in skin diseases.
Yan Z, Liang P
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Aug 28;47(8):1154-1162. doi: 10.11817/j.issn.1672-7347.2022.210332. PMID: 36097784
Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Pembrolizumab in Patients with Refractory Cutaneous Squamous Cell Carcinoma: A Phase II Trial.
Ferrarotto R, Sousa LG, Qing Y, Kaya D, Stephen B, Jain D, Bell D, Pant S, Tsimberidou AM, Janku F, Blumenschein G, Glisson BS, Ahnert JR, Piha-Paul SA, Lee JJ, Wong MK, Lu C, Meric-Bernstam F, Naing A
Adv Ther 2021 Aug;38(8):4581-4591. Epub 2021 Jul 9 doi: 10.1007/s12325-021-01807-6. PMID: 34241781
Immune checkpoint inhibitors to treat cutaneous malignancies.
Barrios DM, Do MH, Phillips GS, Postow MA, Akaike T, Nghiem P, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1239-1253. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.03.131. PMID: 32461079Free PMC Article
Afatinib in the treatment of head and neck squamous cell carcinoma.
Ferrarotto R, Gold KA
Expert Opin Investig Drugs 2014 Jan;23(1):135-43. Epub 2013 Nov 25 doi: 10.1517/13543784.2014.858696. PMID: 24266694

Clinical prediction guides

m6A modification of mRNA in skin diseases.
Yan Z, Liang P
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Aug 28;47(8):1154-1162. doi: 10.11817/j.issn.1672-7347.2022.210332. PMID: 36097784
Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Afatinib and Pembrolizumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (ALPHA Study): A Phase II Study with Biomarker Analysis.
Kao HF, Liao BC, Huang YL, Huang HC, Chen CN, Chen TC, Hong YJ, Chan CY, Chia JS, Hong RL
Clin Cancer Res 2022 Apr 14;28(8):1560-1571. doi: 10.1158/1078-0432.CCR-21-3025. PMID: 35046059Free PMC Article
Immune checkpoint inhibitors to treat cutaneous malignancies.
Barrios DM, Do MH, Phillips GS, Postow MA, Akaike T, Nghiem P, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1239-1253. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.03.131. PMID: 32461079Free PMC Article
ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment.
Gatti V, Fierro C, Annicchiarico-Petruzzelli M, Melino G, Peschiaroli A
Mol Oncol 2019 May;13(5):981-1001. Epub 2019 Mar 22 doi: 10.1002/1878-0261.12473. PMID: 30845357Free PMC Article

Recent systematic reviews

Relative Efficacy of Nonoperative Treatment of Keratoacanthomas.
Seger EW, Tarantino IS, Neill BC, Wang T
J Cutan Med Surg 2020 Jan/Feb;24(1):41-46. Epub 2019 Oct 8 doi: 10.1177/1203475419882336. PMID: 31591899

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