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Unresectable Mucosal Melanoma

MedGen UID:
1711109
•Concept ID:
C5237249
•
Neoplastic Process

Definition

Mucosal melanoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Mucosal Melanoma

Professional guidelines

PubMed

Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
Radiation treatment for adult rare cancers: Oldest and newest indication.
Fiorentino A, Gregucci F, Desideri I, Fiore M, Marino L, Errico A, Di Rito A, Borghetti P, Franco P, Greto D, Donato V
Crit Rev Oncol Hematol 2021 Mar;159:103228. Epub 2021 Jan 27 doi: 10.1016/j.critrevonc.2021.103228. PMID: 33508447
Systemic Therapy for Melanoma: ASCO Guideline.
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358

Recent clinical studies

Etiology

Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed by Nivolumab in Clinically Diverse Patient Populations With Unresectable Stage III or IV Melanoma: CheckMate 401.
Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
BRAF inhibitors: efficacious and tolerable in BRAF-mutant acral and mucosal melanoma.
Bai X, Mao LL, Chi ZH, Sheng XN, Cui CL, Kong Y, Dai J, Wang X, Li SM, Tang BX, Lian B, Zhou L, Yan XQ, Guo J, Si L
Neoplasma 2017;64(4):626-632. doi: 10.4149/neo_2017_419. PMID: 28485171
Update on primary head and neck mucosal melanoma.
López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, Shaha AR, Hunt JL, de Bree R, Takes RP, Rinaldo A, Ferlito A
Head Neck 2016 Jan;38(1):147-55. Epub 2015 May 22 doi: 10.1002/hed.23872. PMID: 25242350Free PMC Article
Single-fraction stereotactic body radiation therapy for sinonasal malignant melanoma.
Bourgeois DJ 3rd, Singh AK
Head Neck 2015 Mar;37(3):E34-7. Epub 2014 Jul 21 doi: 10.1002/hed.23788. PMID: 24891086

Diagnosis

Efficacy and safety of interferon-alpha 1b combined with PD-1 monoclonal antibody in patients with unresectable stage IV melanoma: a retrospective study.
Zhu G, Shi Q, Zhao B, Liu Y, Feng T, Li C, Gao T
J Cancer Res Clin Oncol 2023 Aug;149(9):6263-6269. Epub 2023 Jan 30 doi: 10.1007/s00432-023-04596-3. PMID: 36717393
CDK4 and TERT amplification in head and neck mucosal melanoma.
Lyu J, Miao Y, Yu F, Chang C, Guo W, Zhu H
J Oral Pathol Med 2021 Nov;50(10):971-978. Epub 2021 Apr 12 doi: 10.1111/jop.13180. PMID: 33797827
Multicenter prospective phase II trial of nivolumab in patients with unresectable or metastatic mucosal melanoma.
Nomura M, Oze I, Masuishi T, Yokota T, Satake H, Iwasawa S, Kato K, Andoh M
Int J Clin Oncol 2020 May;25(5):972-977. Epub 2020 Jan 14 doi: 10.1007/s10147-020-01618-9. PMID: 31938955
Update on primary head and neck mucosal melanoma.
López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, Shaha AR, Hunt JL, de Bree R, Takes RP, Rinaldo A, Ferlito A
Head Neck 2016 Jan;38(1):147-55. Epub 2015 May 22 doi: 10.1002/hed.23872. PMID: 25242350Free PMC Article
Diagnosis and treatment of KIT-mutant metastatic melanoma.
Lyle M, Long GV
J Clin Oncol 2013 Sep 10;31(26):3176-81. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.50.4662. PMID: 23940219

Therapy

First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed by Nivolumab in Clinically Diverse Patient Populations With Unresectable Stage III or IV Melanoma: CheckMate 401.
Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
Atezolizumab plus Bevacizumab in Patients with Unresectable or Metastatic Mucosal Melanoma: A Multicenter, Open-Label, Single-Arm Phase II Study.
Mao L, Fang M, Chen Y, Wei X, Cao J, Lin J, Zhang P, Chen L, Cao X, Chen Y, Guo J, Si L
Clin Cancer Res 2022 Nov 1;28(21):4642-4648. doi: 10.1158/1078-0432.CCR-22-1528. PMID: 36044526Free PMC Article
Histone Deacetylase (HDAC) Inhibitors: A Promising Weapon to Tackle Therapy Resistance in Melanoma.
Palamaris K, Moutafi M, Gakiopoulou H, Theocharis S
Int J Mol Sci 2022 Mar 27;23(7) doi: 10.3390/ijms23073660. PMID: 35409020Free PMC Article
Systemic Therapy for Melanoma: ASCO Guideline.
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358
KIT as an Oncogenic Driver in Melanoma: An Update on Clinical Development.
Meng D, Carvajal RD
Am J Clin Dermatol 2019 Jun;20(3):315-323. doi: 10.1007/s40257-018-0414-1. PMID: 30707374

Prognosis

Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed by Nivolumab in Clinically Diverse Patient Populations With Unresectable Stage III or IV Melanoma: CheckMate 401.
Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
Update on primary head and neck mucosal melanoma.
López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, Shaha AR, Hunt JL, de Bree R, Takes RP, Rinaldo A, Ferlito A
Head Neck 2016 Jan;38(1):147-55. Epub 2015 May 22 doi: 10.1002/hed.23872. PMID: 25242350Free PMC Article
Single-fraction stereotactic body radiation therapy for sinonasal malignant melanoma.
Bourgeois DJ 3rd, Singh AK
Head Neck 2015 Mar;37(3):E34-7. Epub 2014 Jul 21 doi: 10.1002/hed.23788. PMID: 24891086
Head and neck mucosal melanoma.
Mendenhall WM, Amdur RJ, Hinerman RW, Werning JW, Villaret DB, Mendenhall NP
Am J Clin Oncol 2005 Dec;28(6):626-30. doi: 10.1097/01.coc.0000170805.14058.d3. PMID: 16317276

Clinical prediction guides

First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed by Nivolumab in Clinically Diverse Patient Populations With Unresectable Stage III or IV Melanoma: CheckMate 401.
Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
Real-world safety and effectiveness of pembrolizumab in Japanese patients with radically unresectable melanoma: An all-case postmarketing surveillance in Japan.
Yamazaki N, Shimizu A, Ozaki M, Hamada M, Takeuchi N, Ito Y, Maekawa S
J Dermatol 2022 Nov;49(11):1096-1105. Epub 2022 Jul 27 doi: 10.1111/1346-8138.16518. PMID: 35896505Free PMC Article
Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma.
Moya-Plana A, Herrera Gómez RG, Rossoni C, Dercle L, Ammari S, Girault I, Roy S, Scoazec JY, Vagner S, Janot F, Eggermont AMM, Robert C
Cancer Immunol Immunother 2019 Jul;68(7):1171-1178. Epub 2019 Jun 7 doi: 10.1007/s00262-019-02351-7. PMID: 31172258
Predicting marker for early progression in unresectable melanoma treated with nivolumab.
Kondo T, Nomura M, Otsuka A, Nonomura Y, Kaku Y, Matsumoto S, Muto M
Int J Clin Oncol 2019 Mar;24(3):323-327. Epub 2018 Aug 30 doi: 10.1007/s10147-018-1345-9. PMID: 30168088
Upcoming strategies for the treatment of metastatic melanoma.
Spagnolo F, Queirolo P
Arch Dermatol Res 2012 Apr;304(3):177-84. Epub 2012 Feb 17 doi: 10.1007/s00403-012-1223-7. PMID: 22350184

Recent systematic reviews

c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis.
Steeb T, Wessely A, Petzold A, Kohl C, Erdmann M, Berking C, Heppt MV
Eur J Cancer 2021 Nov;157:348-357. Epub 2021 Sep 22 doi: 10.1016/j.ejca.2021.08.015. PMID: 34562816
Systemic Therapy for Melanoma: ASCO Guideline.
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358

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