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Recurrent High Risk Chronic Myelomonocytic Leukemia

MedGen UID:
1711123
Concept ID:
C5238539
Neoplastic Process

Definition

The reemergence of high risk chronic myelomonocytic leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent High Risk Chronic Myelomonocytic Leukemia

Recent clinical studies

Etiology

Montalban-Bravo G, Jabbour E, Borthakur G, Kadia T, Ravandi F, Chien K, Pemmaraju N, Hammond D, Dong XQ, Huang X, Schneider H, John R, Kanagal-Shamana R, Loghavi S, Kantarjian H, Garcia-Manero G
Br J Haematol 2024 Mar;204(3):898-909. Epub 2023 Nov 10 doi: 10.1111/bjh.19193. PMID: 37946611
Binder M, Carr RM, Lasho TL, Finke CM, Mangaonkar AA, Pin CL, Berger KR, Mazzone A, Potluri S, Ordog T, Robertson KD, Marks DL, Fernandez-Zapico ME, Gaspar-Maia A, Patnaik MM
Nat Commun 2022 Mar 17;13(1):1434. doi: 10.1038/s41467-022-29142-6. PMID: 35301312Free PMC Article
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Wlodarski MW, Collin M, Horwitz MS
Semin Hematol 2017 Apr;54(2):81-86. Epub 2017 May 10 doi: 10.1053/j.seminhematol.2017.05.002. PMID: 28637621Free PMC Article
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307

Diagnosis

DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307
Thiede Ch, Lutterbeck K, Oelschlägel U, Kiehl M, Steudel Ch, Platzbecker U, Brendel C, Fauser AA, Neubauer A, Ehninger G, Bornhäuser M
Ann Hematol 2002;81 Suppl 2:S27-8. PMID: 12611065

Therapy

Montalban-Bravo G, Jabbour E, Borthakur G, Kadia T, Ravandi F, Chien K, Pemmaraju N, Hammond D, Dong XQ, Huang X, Schneider H, John R, Kanagal-Shamana R, Loghavi S, Kantarjian H, Garcia-Manero G
Br J Haematol 2024 Mar;204(3):898-909. Epub 2023 Nov 10 doi: 10.1111/bjh.19193. PMID: 37946611
Jiang JL, Gao WH, Wang LN, Wan M, Wang L, Hu J
Transplant Cell Ther 2023 Aug;29(8):512.e1-512.e8. Epub 2023 May 30 doi: 10.1016/j.jtct.2023.05.017. PMID: 37263418
Wattebled KJ, Drumez E, Coiteux V, Magro L, Srour M, Chauvet P, Quesnel B, Duhamel A, Yakoub-Agha I, Beauvais D
Ann Hematol 2022 Jun;101(6):1321-1331. Epub 2022 Mar 29 doi: 10.1007/s00277-022-04821-y. PMID: 35352216
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Quesada AE, Routbort MJ, DiNardo CD, Bueso-Ramos CE, Kanagal-Shamanna R, Khoury JD, Thakral B, Zuo Z, Yin CC, Loghavi S, Ok CY, Wang SA, Tang Z, Bannon SA, Benton CB, Garcia-Manero G, Kantarjian H, Luthra R, Medeiros LJ, Patel KP
Am J Hematol 2019 Jul;94(7):757-766. Epub 2019 May 7 doi: 10.1002/ajh.25486. PMID: 30963592

Prognosis

Montalban-Bravo G, Jabbour E, Borthakur G, Kadia T, Ravandi F, Chien K, Pemmaraju N, Hammond D, Dong XQ, Huang X, Schneider H, John R, Kanagal-Shamana R, Loghavi S, Kantarjian H, Garcia-Manero G
Br J Haematol 2024 Mar;204(3):898-909. Epub 2023 Nov 10 doi: 10.1111/bjh.19193. PMID: 37946611
Jiang JL, Gao WH, Wang LN, Wan M, Wang L, Hu J
Transplant Cell Ther 2023 Aug;29(8):512.e1-512.e8. Epub 2023 May 30 doi: 10.1016/j.jtct.2023.05.017. PMID: 37263418
Hartmann L, Haferlach C, Meggendorfer M, Kern W, Haferlach T, Stengel A
Genes Chromosomes Cancer 2019 Oct;58(10):698-704. Epub 2019 May 1 doi: 10.1002/gcc.22761. PMID: 30994218
Gyurkocza B, Gutman J, Nemecek ER, Bar M, Milano F, Ramakrishnan A, Scott B, Fang M, Wood B, Pagel JM, Baumgart J, Delaney C, Maziarz RT, Sandmaier BM, Estey EH, Appelbaum FR, Storer BE, Deeg HJ
Biol Blood Marrow Transplant 2014 Apr;20(4):549-55. Epub 2014 Jan 16 doi: 10.1016/j.bbmt.2014.01.009. PMID: 24440648Free PMC Article
Eissa H, Gooley TA, Sorror ML, Nguyen F, Scott BL, Doney K, Loeb KR, Martin PJ, Pagel JM, Radich JP, Sandmaier BM, Warren EH, Storb R, Appelbaum FR, Deeg HJ
Biol Blood Marrow Transplant 2011 Jun;17(6):908-15. Epub 2010 Oct 6 doi: 10.1016/j.bbmt.2010.09.018. PMID: 20932924Free PMC Article

Clinical prediction guides

Montalban-Bravo G, Jabbour E, Borthakur G, Kadia T, Ravandi F, Chien K, Pemmaraju N, Hammond D, Dong XQ, Huang X, Schneider H, John R, Kanagal-Shamana R, Loghavi S, Kantarjian H, Garcia-Manero G
Br J Haematol 2024 Mar;204(3):898-909. Epub 2023 Nov 10 doi: 10.1111/bjh.19193. PMID: 37946611
Gyurkocza B, Gutman J, Nemecek ER, Bar M, Milano F, Ramakrishnan A, Scott B, Fang M, Wood B, Pagel JM, Baumgart J, Delaney C, Maziarz RT, Sandmaier BM, Estey EH, Appelbaum FR, Storer BE, Deeg HJ
Biol Blood Marrow Transplant 2014 Apr;20(4):549-55. Epub 2014 Jan 16 doi: 10.1016/j.bbmt.2014.01.009. PMID: 24440648Free PMC Article
Han DK, Baek HJ, Kim SY, Hwang TJ, Kook H
Yonsei Med J 2013 Jan 1;54(1):62-70. doi: 10.3349/ymj.2013.54.1.62. PMID: 23225800Free PMC Article
Eissa H, Gooley TA, Sorror ML, Nguyen F, Scott BL, Doney K, Loeb KR, Martin PJ, Pagel JM, Radich JP, Sandmaier BM, Warren EH, Storb R, Appelbaum FR, Deeg HJ
Biol Blood Marrow Transplant 2011 Jun;17(6):908-15. Epub 2010 Oct 6 doi: 10.1016/j.bbmt.2010.09.018. PMID: 20932924Free PMC Article
Cortes J, Giles F, O'Brien S, Thomas D, Albitar M, Rios MB, Talpaz M, Garcia-Manero G, Faderl S, Letvak L, Salvado A, Kantarjian H
Cancer 2003 Jun 1;97(11):2760-6. doi: 10.1002/cncr.11416. PMID: 12767088

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