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Renal lymphocytic tubulitis

MedGen UID:
1711181
•Concept ID:
C5397613
•
Disease or Syndrome
HPO: HP:0032589

Definition

Infiltration of the renal tubular epithelium by lymphocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal lymphocytic tubulitis

Professional guidelines

PubMed

Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.
Yamamoto I, Kawabe M, Hayashi A, Kobayashi A, Yamamoto H, Yokoo T
Nephron 2023;147 Suppl 1:74-79. Epub 2023 Mar 16 doi: 10.1159/000530158. PMID: 36928337
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729

Recent clinical studies

Etiology

Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.
Yamamoto I, Kawabe M, Hayashi A, Kobayashi A, Yamamoto H, Yokoo T
Nephron 2023;147 Suppl 1:74-79. Epub 2023 Mar 16 doi: 10.1159/000530158. PMID: 36928337
Renal Manifestations of Common Variable Immunodeficiency.
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Tubulointerstitial Nephritis with IgM-Positive Plasma Cells.
Takahashi N, Saeki T, Komatsuda A, Munemura C, Fukui T, Imai N, Homma N, Hatta T, Samejima KI, Fujimoto T, Omori H, Ito Y, Nishikawa Y, Kobayashi M, Morikawa Y, Fukushima S, Yokoi S, Mikami D, Kasuno K, Kimura H, Nemoto T, Nakamoto Y, Sada K, Sugai M, Naiki H, Yoshida H, Narita I, Saito Y, Iwano M
J Am Soc Nephrol 2017 Dec;28(12):3688-3698. Epub 2017 Aug 9 doi: 10.1681/ASN.2016101074. PMID: 28794148Free PMC Article
Acute kidney graft rejection morphology and immunology.
Andersen CB
APMIS Suppl 1997;67:1-35. PMID: 9063492

Diagnosis

Renal Manifestations of Common Variable Immunodeficiency.
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037
Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade.
Robertson H, Wong WK, Talbot D, Burt AD, Kirby JA
Transplantation 2001 Jan 27;71(2):306-13. doi: 10.1097/00007890-200101270-00024. PMID: 11213078

Therapy

Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
The causes, significance and consequences of inflammatory fibrosis in kidney transplantation: The Banff i-IFTA lesion.
Nankivell BJ, Shingde M, Keung KL, Fung CL, Borrows RJ, O'Connell PJ, Chapman JR
Am J Transplant 2018 Feb;18(2):364-376. Epub 2018 Jan 3 doi: 10.1111/ajt.14609. PMID: 29194971
Omeprazole-induced acute interstitial nephritis: a possible Th1-Th17-mediated injury?
Berney-Meyer L, Hung N, Slatter T, Schollum JB, Kitching AR, Walker RJ
Nephrology (Carlton) 2014 Jun;19(6):359-65. doi: 10.1111/nep.12226. PMID: 24629073
Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade.
Robertson H, Wong WK, Talbot D, Burt AD, Kirby JA
Transplantation 2001 Jan 27;71(2):306-13. doi: 10.1097/00007890-200101270-00024. PMID: 11213078

Prognosis

The Pathophysiology and Impact of Inflammation in Nonscarred Renal Interstitium: The Banff i Lesion.
Nankivell BJ, P'Ng CH, Shingde M, Viswanathan S, Achan A, Renthawa J, Sharma RN, Chapman JR
Transplantation 2020 Apr;104(4):835-846. doi: 10.1097/TP.0000000000002887. PMID: 31369519
Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
The causes, significance and consequences of inflammatory fibrosis in kidney transplantation: The Banff i-IFTA lesion.
Nankivell BJ, Shingde M, Keung KL, Fung CL, Borrows RJ, O'Connell PJ, Chapman JR
Am J Transplant 2018 Feb;18(2):364-376. Epub 2018 Jan 3 doi: 10.1111/ajt.14609. PMID: 29194971
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037

Clinical prediction guides

Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
Interpreting CD56+ and CD163+ infiltrates in early versus late renal transplant biopsies.
Shin S, Kim YH, Cho YM, Park Y, Han S, Choi BH, Choi JY, Han DJ
Am J Nephrol 2015;41(4-5):362-9. Epub 2015 Jun 18 doi: 10.1159/000430473. PMID: 26087825
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037
Tubulitis in renal allograft rejection: role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells.
Wong WK, Robertson H, Carroll HP, Ali S, Kirby JA
Transplantation 2003 Feb 27;75(4):505-14. doi: 10.1097/01.TP.0000045708.39879.C7. PMID: 12605119
Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade.
Robertson H, Wong WK, Talbot D, Burt AD, Kirby JA
Transplantation 2001 Jan 27;71(2):306-13. doi: 10.1097/00007890-200101270-00024. PMID: 11213078

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