U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Locally Recurrent Merkel Cell Carcinoma

MedGen UID:
1711792
Concept ID:
C5237417
Neoplastic Process

Definition

The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Recurrent Merkel Cell Carcinoma

Professional guidelines

PubMed

Singh N, McClure EM, Akaike T, Park SY, Huynh ET, Goff PH, Nghiem P
Curr Treat Options Oncol 2023 Sep;24(9):1231-1258. Epub 2023 Jul 5 doi: 10.1007/s11864-023-01118-8. PMID: 37403007
Mendenhall WM, Morris CG, Kirwan JM, Amdur RJ, Shaw C, Dziegielewski PT
Acta Oncol 2018 Mar;57(3):320-323. Epub 2017 Jul 15 doi: 10.1080/0284186X.2017.1349926. PMID: 28712323
Matkowski R, Lata E, Zietek M, Halon A, Forgacz J, Szynglarewicz B
J Dermatolog Treat 2014 Oct;25(5):409-14. Epub 2013 Aug 13 doi: 10.3109/09546634.2012.756969. PMID: 23216365

Recent clinical studies

Etiology

Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Wilken R, Carucci J, Stevenson ML
Semin Respir Crit Care Med 2021 Jun;42(3):483-496. Epub 2021 May 24 doi: 10.1055/s-0041-1728798. PMID: 34030209
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, Pusceddu S
Radiother Oncol 2019 May;134:211-219. Epub 2019 Feb 28 doi: 10.1016/j.radonc.2019.02.015. PMID: 31005218
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777

Diagnosis

Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777
Mendenhall WM, Morris CG, Kirwan JM, Amdur RJ, Shaw C, Dziegielewski PT
Acta Oncol 2018 Mar;57(3):320-323. Epub 2017 Jul 15 doi: 10.1080/0284186X.2017.1349926. PMID: 28712323
Dancey AL, Rayatt SS, Soon C, Ilchshyn A, Brown I, Srivastava S
J Plast Reconstr Aesthet Surg 2006;59(12):1294-9. Epub 2006 Jun 6 doi: 10.1016/j.bjps.2006.03.044. PMID: 17113506
Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW
Ann Surg Oncol 2001 Apr;8(3):204-8. doi: 10.1007/s10434-001-0204-4. PMID: 11314935

Therapy

Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Kang C
Drugs 2023 Jun;83(8):731-737. doi: 10.1007/s40265-023-01884-7. PMID: 37184754
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, Pusceddu S
Radiother Oncol 2019 May;134:211-219. Epub 2019 Feb 28 doi: 10.1016/j.radonc.2019.02.015. PMID: 31005218
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777

Prognosis

Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777
Raju S, Vazirnia A, Totri C, Hata TR
Dermatol Surg 2014 Dec;40(12):1273-83. doi: 10.1097/DSS.0000000000000131. PMID: 25350122
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
O'Connor WJ, Brodland DG
Dermatol Surg 1996 Mar;22(3):262-7. doi: 10.1111/j.1524-4725.1996.tb00317.x. PMID: 8599738

Clinical prediction guides

Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Coskun O, Sahin H, Yalcin S, Sahin YC, Coskun U
J Oncol Pharm Pract 2023 Sep;29(6):1510-1515. Epub 2023 May 30 doi: 10.1177/10781552231177712. PMID: 37254496
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, Pusceddu S
Radiother Oncol 2019 May;134:211-219. Epub 2019 Feb 28 doi: 10.1016/j.radonc.2019.02.015. PMID: 31005218
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J
Lancet 2018 May 26;391(10135):2128-2139. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)30789-X. PMID: 29754777

Recent systematic reviews

Uitentuis SE, Bambach C, Elshot YS, Limpens J, van Akkooi ACJ, Bekkenk MW
Dermatol Surg 2022 Apr 1;48(4):387-394. doi: 10.1097/DSS.0000000000003402. PMID: 35165221
Truong K, Goldinger SM, Chou S, Howle JR, Veness MJ, Fernandez-Peñas P, Varey AHR
Australas J Dermatol 2022 Feb;63(1):e6-e12. Epub 2021 Dec 7 doi: 10.1111/ajd.13758. PMID: 34873684
Palencia R, Sandhu A, Webb S, Blaikie T, Bharmal M
Future Oncol 2021 Dec;17(34):4813-4822. Epub 2021 Sep 8 doi: 10.2217/fon-2021-0574. PMID: 34494443
Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, Pusceddu S
Radiother Oncol 2019 May;134:211-219. Epub 2019 Feb 28 doi: 10.1016/j.radonc.2019.02.015. PMID: 31005218
Raju S, Vazirnia A, Totri C, Hata TR
Dermatol Surg 2014 Dec;40(12):1273-83. doi: 10.1097/DSS.0000000000000131. PMID: 25350122

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...