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Increased oocyte death

MedGen UID:
1712135
•Concept ID:
C5397598
•
Cell or Molecular Dysfunction
HPO: HP:0032571

Definition

An increase in death of oocytes, the female germ cell (egg cell), which can be observed clinically in the setting of in vitro fertilization. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased oocyte death

Conditions with this feature

Oocyte maturation defect 7
MedGen UID:
1684736
•Concept ID:
C5231407
•
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-7 (OZEMA7) is characterized by infertility due to oocyte death, which may occur before or after fertilization (Sang et al., 2019). For a discussion of genetic heterogeneity of OZEMA, see 615774.
See: Condition Record
Oocyte maturation defect 7

Professional guidelines

PubMed

Long term all-cause and cardiovascular disease mortality among women who undergo fertility treatment.
Yiallourou SR, Magliano D, Haregu TN, Carrington MJ, Rolnik DL, Rombauts L, Rodrigues A, Ball J, Bruinsma FJ, Da Silva Costa F
Med J Aust 2022 Nov 21;217(10):532-537. Epub 2022 Oct 9 doi: 10.5694/mja2.51734. PMID: 36209740Free PMC Article
Birth Outcomes by Infertility Treatment: Analyses of the Population-Based Cohort: Massachusetts Outcomes Study of Assisted Reproductive Technologies (MOSART).
Luke B, Stern JE, Kotelchuck M, Declercq ER, Anderka M, Diop H
J Reprod Med 2016 Mar-Apr;61(3-4):114-27. PMID: 27172633Free PMC Article
Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis.
Richards JS, Fan HY, Liu Z, Tsoi M, Laguë MN, Boyer A, Boerboom D
Oncogene 2012 Mar 22;31(12):1504-20. Epub 2011 Aug 22 doi: 10.1038/onc.2011.341. PMID: 21860425Free PMC Article

Recent clinical studies

Etiology

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity.
Ni Z, Li Y, Song D, Ding J, Mei S, Sun S, Cheng W, Yu J, Zhou L, Kuang Y, Li M, Cai Z, Yu C
Cell Death Dis 2022 Jul 4;13(7):579. doi: 10.1038/s41419-022-05037-8. PMID: 35787614Free PMC Article
Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights.
Gonzalez MB, Robker RL, Rose RD
Biol Reprod 2022 Feb 22;106(2):338-350. doi: 10.1093/biolre/ioab228. PMID: 34918035
Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell.
Takahashi A, Yousif A, Hong L, Chefetz I
J Mol Med (Berl) 2021 May;99(5):637-650. Epub 2021 Feb 27 doi: 10.1007/s00109-021-02055-5. PMID: 33641066
Prolonging Reproductive Life after Cancer: The Need for Fertoprotective Therapies.
Woodard TL, Bolcun-Filas E
Trends Cancer 2016 May;2(5):222-233. Epub 2016 Apr 23 doi: 10.1016/j.trecan.2016.03.006. PMID: 28741510
Pre-implantation genetic diagnosis.
Findlay I
Br Med Bull 2000;56(3):672-90. doi: 10.1258/0007142001903463. PMID: 11255553

Diagnosis

Redox Regulation to Modulate Phosphorylation Events in Human Spermatozoa.
Serafini S, O'Flaherty C
Antioxid Redox Signal 2022 Sep;37(7-9):437-450. Epub 2021 Dec 15 doi: 10.1089/ars.2021.0117. PMID: 34714121
Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis.
Zeng X, Shi G, He Q, Zhu P
Sci Rep 2021 Oct 21;11(1):20799. doi: 10.1038/s41598-021-00268-9. PMID: 34675265Free PMC Article
Ovarian damage from chemotherapy and current approaches to its protection.
Spears N, Lopes F, Stefansdottir A, Rossi V, De Felici M, Anderson RA, Klinger FG
Hum Reprod Update 2019 Nov 5;25(6):673-693. doi: 10.1093/humupd/dmz027. PMID: 31600388Free PMC Article
Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary.
Bedoschi GM, Navarro PA, Oktay KH
Panminerva Med 2019 Mar;61(1):68-75. Epub 2018 Jun 28 doi: 10.23736/S0031-0808.18.03494-8. PMID: 29962184
Pre-implantation genetic diagnosis.
Findlay I
Br Med Bull 2000;56(3):672-90. doi: 10.1258/0007142001903463. PMID: 11255553

Therapy

Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice.
Winship AL, Alesi LR, Sant S, Stringer JM, Cantavenera A, Hegarty T, Requesens CL, Liew SH, Sarma U, Griffiths MJ, Zerafa N, Fox SB, Brown E, Caramia F, Zareie P, La Gruta NL, Phillips KA, Strasser A, Loi S, Hutt KJ
Nat Cancer 2022 Aug;3(8):1-13. Epub 2022 Aug 25 doi: 10.1038/s43018-022-00413-x. PMID: 36008687
Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights.
Gonzalez MB, Robker RL, Rose RD
Biol Reprod 2022 Feb 22;106(2):338-350. doi: 10.1093/biolre/ioab228. PMID: 34918035
Ovarian damage from chemotherapy and current approaches to its protection.
Spears N, Lopes F, Stefansdottir A, Rossi V, De Felici M, Anderson RA, Klinger FG
Hum Reprod Update 2019 Nov 5;25(6):673-693. doi: 10.1093/humupd/dmz027. PMID: 31600388Free PMC Article
Necroptosis in stressed ovary.
Chaudhary GR, Yadav PK, Yadav AK, Tiwari M, Gupta A, Sharma A, Pandey AN, Pandey AK, Chaube SK
J Biomed Sci 2019 Jan 21;26(1):11. doi: 10.1186/s12929-019-0504-2. PMID: 30665407Free PMC Article
Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary.
Bedoschi GM, Navarro PA, Oktay KH
Panminerva Med 2019 Mar;61(1):68-75. Epub 2018 Jun 28 doi: 10.23736/S0031-0808.18.03494-8. PMID: 29962184

Prognosis

Brain edema after oocyte retrieval: a case report.
Fan L, Wen W, Zhou H
BMC Womens Health 2022 Dec 12;22(1):519. doi: 10.1186/s12905-022-02098-x. PMID: 36510239Free PMC Article
Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis.
Zeng X, Shi G, He Q, Zhu P
Sci Rep 2021 Oct 21;11(1):20799. doi: 10.1038/s41598-021-00268-9. PMID: 34675265Free PMC Article
Breast cancer and fertility preservation.
Kim SS, Klemp J, Fabian C
Fertil Steril 2011 Apr;95(5):1535-43. Epub 2011 Jan 26 doi: 10.1016/j.fertnstert.2011.01.003. PMID: 21272867Free PMC Article
Advanced maternal age. Part I: obstetric complications.
Usta IM, Nassar AH
Am J Perinatol 2008 Sep;25(8):521-34. Epub 2008 Sep 4 doi: 10.1055/s-0028-1085620. PMID: 18773378
The origin of monozygotic twinning.
Scott L
Reprod Biomed Online 2002 Nov-Dec;5(3):276-84. doi: 10.1016/s1472-6483(10)61833-0. PMID: 12470527

Clinical prediction guides

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity.
Ni Z, Li Y, Song D, Ding J, Mei S, Sun S, Cheng W, Yu J, Zhou L, Kuang Y, Li M, Cai Z, Yu C
Cell Death Dis 2022 Jul 4;13(7):579. doi: 10.1038/s41419-022-05037-8. PMID: 35787614Free PMC Article
Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis.
Zeng X, Shi G, He Q, Zhu P
Sci Rep 2021 Oct 21;11(1):20799. doi: 10.1038/s41598-021-00268-9. PMID: 34675265Free PMC Article
Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility.
Odening KE, Bodi I, Franke G, Rieke R, Ryan de Medeiros A, Perez-Feliz S, Fürniss H, Mettke L, Michaelides K, Lang CN, Steinfurt J, Pantulu ND, Ziupa D, Menza M, Zehender M, Bugger H, Peyronnet R, Behrends JC, Doleschall Z, Zur Hausen A, Bode C, Jolivet G, Brunner M
Eur Heart J 2019 Mar 7;40(10):842-853. doi: 10.1093/eurheartj/ehy761. PMID: 30496390
C-Abl is not actıvated in DNA damage-induced and Tap63-mediated oocyte apoptosıs in human ovary.
Bildik G, Acılan C, Sahin GN, Karahuseyinoglu S, Oktem O
Cell Death Dis 2018 Sep 20;9(10):943. doi: 10.1038/s41419-018-1026-7. PMID: 30237472Free PMC Article
Ovarian hyperstimulation syndrome after superovulation using GnRH agonists for IVF and related procedures.
Rizk B, Smitz J
Hum Reprod 1992 Mar;7(3):320-7. doi: 10.1093/oxfordjournals.humrep.a137642. PMID: 1587936

Recent systematic reviews

Increased Risk of Aortic Dissection Associated With Pregnancy in Women With Turner Syndrome: A Systematic Review.
Hynes JS, Kuller JA, Goldstein SA, Ward CC, Muasher SJ
Obstet Gynecol Surv 2020 Sep;75(9):566-575. doi: 10.1097/OGX.0000000000000833. PMID: 32997149
Gap junction connexins in female reproductive organs: implications for women's reproductive health.
Winterhager E, Kidder GM
Hum Reprod Update 2015 May-Jun;21(3):340-52. Epub 2015 Feb 9 doi: 10.1093/humupd/dmv007. PMID: 25667189
Ovulation triggers in anovulatory women undergoing ovulation induction.
George K, Kamath MS, Nair R, Tharyan P
Cochrane Database Syst Rev 2014 Jan 31;(1):CD006900. doi: 10.1002/14651858.CD006900.pub3. PMID: 24482059

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