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Bone Void

MedGen UID:
1712357
•Concept ID:
C5237318
•
Anatomical Abnormality

Definition

A defect or discontinuity of bone resulting from a pathologic process, including trauma and degenerative or neoplastic processes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Void

Professional guidelines

PubMed

Conventional Cartilaginous Tumors: Evaluation and Treatment.
Wells ME, Eckhoff MD, Kafchinski LA, Polfer EM, Potter BK
JBJS Rev 2021 May 6;9(5) doi: 10.2106/JBJS.RVW.20.00159. PMID: 34881859
Demineralized Bone and BMPs: Basic Science and Clinical Utility.
Glowacki J
J Oral Maxillofac Surg 2015 Dec;73(12 Suppl):S126-31. doi: 10.1016/j.joms.2015.04.009. PMID: 26608140
Synthetic calcium phosphate ceramics for treatment of bone fractures.
Döbelin N, Luginbühl R, Bohner M
Chimia (Aarau) 2010;64(10):723-9. doi: 10.2533/chimia.2010.723. PMID: 21138161

Recent clinical studies

Etiology

Lack of Efficacy of Bone Void Filling Materials in Medial Opening-Wedge High Tibial Osteotomy: A Systematic Review and Network Meta-analysis.
Mao Y, You M, Zhang L, Li J, Fu W
Arthroscopy 2023 Jul;39(7):1735-1757. Epub 2022 Dec 26 doi: 10.1016/j.arthro.2022.11.039. PMID: 36581002
Clinical parameters and radiographic resorption of a novel magnesium based bone void filler.
Magister S, Kolaczko J, Sattar A, Wetzel RJ
Injury 2022 Mar;53(3):947-952. Epub 2021 Nov 30 doi: 10.1016/j.injury.2021.11.057. PMID: 34895713
Electrospun, synthetic bone void filler promotes human MSC function and BMP-2 mediated spinal fusion.
Glaeser JD, Salehi K, Kanim LE, Ju DG, Hyuk Yang J, Behrens PH, Eberlein SA, Metzger MF, Arabi Y, Stefanovic T, Sheyn D, W Bae H
J Biomater Appl 2020 Oct-Nov;35(4-5):532-543. Epub 2020 Jul 5 doi: 10.1177/0885328220937999. PMID: 32627633Free PMC Article
Orthobiologics A Comprehensive Review of the Current Evidence and Use in Orthopedic Subspecialties.
Bravo D, Jazrawi L, Cardone DA, Virk M, Passias PG, Einhorn TA, Leucht P
Bull Hosp Jt Dis (2013) 2018 Dec;76(4):223-231. PMID: 31513506
The role of bone void fillers in medial opening wedge high tibial osteotomy: a systematic review.
Slevin O, Ayeni OR, Hinterwimmer S, Tischer T, Feucht MJ, Hirschmann MT
Knee Surg Sports Traumatol Arthrosc 2016 Nov;24(11):3584-3598. Epub 2016 Aug 24 doi: 10.1007/s00167-016-4297-5. PMID: 27557796

Diagnosis

Time to full weight-bearing with the use of a calcium sulfate-calcium phosphate bone substitute as a bone void filler following extended curettage in the treatment of primary benign bone tumours.
Gyemi L, Selznick A, Petrisor B, Ghert M
J Orthop Surg (Hong Kong) 2024 May-Aug;32(2):10225536241254200. doi: 10.1177/10225536241254200. PMID: 38733211
Distribution of bone voids in the thoracolumbar spine in Chinese adults with and without osteoporosis: A cross-sectional multi-center study based on 464 vertebrae.
Lin J, Liu Z, Fu G, Zhang H, Chen C, Qi H, Jiang K, Zhang C, Ma C, Yang K, Wang C, Tan B, Zhu Q, Ding Y, Li C, Zheng Q, Cai D, Lu WW
Bone 2023 Jul;172:116749. Epub 2023 Mar 25 doi: 10.1016/j.bone.2023.116749. PMID: 36972755
Conventional Cartilaginous Tumors: Evaluation and Treatment.
Wells ME, Eckhoff MD, Kafchinski LA, Polfer EM, Potter BK
JBJS Rev 2021 May 6;9(5) doi: 10.2106/JBJS.RVW.20.00159. PMID: 34881859
Bone Grafts, Substitutes, and Augments in Benign Orthopaedic Conditions Current Concepts.
Blank A, Riesgo A, Gitelis S, Rapp T
Bull Hosp Jt Dis (2013) 2017 Apr;75(2):119-127. PMID: 28583058
Fracture of the talus as a complication of subtalar arthroereisis.
Corpuz M, Shofler D, Labovitz J, Hodor L, Yu K
J Foot Ankle Surg 2012 Jan-Feb;51(1):91-4. Epub 2011 Oct 1 doi: 10.1053/j.jfas.2011.08.008. PMID: 21962334

Therapy

Lack of Efficacy of Bone Void Filling Materials in Medial Opening-Wedge High Tibial Osteotomy: A Systematic Review and Network Meta-analysis.
Mao Y, You M, Zhang L, Li J, Fu W
Arthroscopy 2023 Jul;39(7):1735-1757. Epub 2022 Dec 26 doi: 10.1016/j.arthro.2022.11.039. PMID: 36581002
Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration.
Diaz-Rodriguez P, López-Álvarez M, Serra J, González P, Landín M
Mar Drugs 2019 Aug 15;17(8) doi: 10.3390/md17080471. PMID: 31443166Free PMC Article
The role of bone void fillers in medial opening wedge high tibial osteotomy: a systematic review.
Slevin O, Ayeni OR, Hinterwimmer S, Tischer T, Feucht MJ, Hirschmann MT
Knee Surg Sports Traumatol Arthrosc 2016 Nov;24(11):3584-3598. Epub 2016 Aug 24 doi: 10.1007/s00167-016-4297-5. PMID: 27557796
Demineralized Bone and BMPs: Basic Science and Clinical Utility.
Glowacki J
J Oral Maxillofac Surg 2015 Dec;73(12 Suppl):S126-31. doi: 10.1016/j.joms.2015.04.009. PMID: 26608140
Calcium sulfate bone void filler: a review and a look ahead.
Pietrzak WS, Ronk R
J Craniofac Surg 2000 Jul;11(4):327-33; discussion 334. doi: 10.1097/00001665-200011040-00009. PMID: 11314379

Prognosis

Risk Factors for the Development of Heterotopic Ossification Following Acetabular Fractures: A Systematic Review.
Yeung P, Zarnett O, Lefaivre KA, Guy P
JBJS Rev 2022 Sep 1;10(9) Epub 2022 Sep 22 doi: 10.2106/JBJS.RVW.20.00263. PMID: 36137013
Bioactive glass granules versus standard autologous and allogeneic bone grafts: a randomized trial of 49 adult bone tumor patients with a 10-year follow-up.
Aro HT, Välimäki VV, Strandberg N, Lankinen P, Löyttyniemi E, Saunavaara V, Seppänen M
Acta Orthop 2022 Jun 1;93:519-527. doi: 10.2340/17453674.2022.2808. PMID: 35642498
Impact of a void in the equine medial femoral condyle on bone stresses and peak contact pressures in a finite element model.
Frazer LL, Santschi EM, Fischer KJ
Vet Surg 2019 Feb;48(2):237-246. Epub 2018 Dec 16 doi: 10.1111/vsu.13139. PMID: 30556152
Natural Course of Local Bone Mineralization After Treatment of Benign or Borderline Bone Tumors and Cysts With a Composite Ceramic Bone Graft Substitute.
Horstmann PF, Hettwer WH, Petersen MM
J Clin Densitom 2018 Oct-Dec;21(4):472-479. Epub 2018 Mar 23 doi: 10.1016/j.jocd.2017.12.004. PMID: 29661685
The effect of time to post-operative weightbearing on functional and clinical outcomes in adults with a displaced intra-articular calcaneal fracture; A systematic review and pooled analysis.
De Boer AS, Van Lieshout EMM, Van Moolenbroek G, Den Hartog D, Verhofstad MHJ
Injury 2018 Apr;49(4):743-752. Epub 2018 Feb 21 doi: 10.1016/j.injury.2018.02.021. PMID: 29496317

Clinical prediction guides

Lack of Efficacy of Bone Void Filling Materials in Medial Opening-Wedge High Tibial Osteotomy: A Systematic Review and Network Meta-analysis.
Mao Y, You M, Zhang L, Li J, Fu W
Arthroscopy 2023 Jul;39(7):1735-1757. Epub 2022 Dec 26 doi: 10.1016/j.arthro.2022.11.039. PMID: 36581002
Clinical parameters and radiographic resorption of a novel magnesium based bone void filler.
Magister S, Kolaczko J, Sattar A, Wetzel RJ
Injury 2022 Mar;53(3):947-952. Epub 2021 Nov 30 doi: 10.1016/j.injury.2021.11.057. PMID: 34895713
Fabrication of Gentamicin-Loaded Hydroxyapatite/Collagen Bone-Like Nanocomposite for Anti-Infection Bone Void Fillers.
Oshima S, Sato T, Honda M, Suetsugu Y, Ozeki K, Kikuchi M
Int J Mol Sci 2020 Jan 15;21(2) doi: 10.3390/ijms21020551. PMID: 31952242Free PMC Article
Surgical fixation methods for tibial plateau fractures.
McNamara IR, Smith TO, Shepherd KL, Clark AB, Nielsen DM, Donell S, Hing CB
Cochrane Database Syst Rev 2015 Sep 15;2015(9):CD009679. doi: 10.1002/14651858.CD009679.pub2. PMID: 26370268Free PMC Article
Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties.
Zhang J, Liu W, Schnitzler V, Tancret F, Bouler JM
Acta Biomater 2014 Mar;10(3):1035-49. Epub 2013 Nov 11 doi: 10.1016/j.actbio.2013.11.001. PMID: 24231047

Recent systematic reviews

Lack of Efficacy of Bone Void Filling Materials in Medial Opening-Wedge High Tibial Osteotomy: A Systematic Review and Network Meta-analysis.
Mao Y, You M, Zhang L, Li J, Fu W
Arthroscopy 2023 Jul;39(7):1735-1757. Epub 2022 Dec 26 doi: 10.1016/j.arthro.2022.11.039. PMID: 36581002
Risk Factors for the Development of Heterotopic Ossification Following Acetabular Fractures: A Systematic Review.
Yeung P, Zarnett O, Lefaivre KA, Guy P
JBJS Rev 2022 Sep 1;10(9) Epub 2022 Sep 22 doi: 10.2106/JBJS.RVW.20.00263. PMID: 36137013
The effect of time to post-operative weightbearing on functional and clinical outcomes in adults with a displaced intra-articular calcaneal fracture; A systematic review and pooled analysis.
De Boer AS, Van Lieshout EMM, Van Moolenbroek G, Den Hartog D, Verhofstad MHJ
Injury 2018 Apr;49(4):743-752. Epub 2018 Feb 21 doi: 10.1016/j.injury.2018.02.021. PMID: 29496317
The role of bone void fillers in medial opening wedge high tibial osteotomy: a systematic review.
Slevin O, Ayeni OR, Hinterwimmer S, Tischer T, Feucht MJ, Hirschmann MT
Knee Surg Sports Traumatol Arthrosc 2016 Nov;24(11):3584-3598. Epub 2016 Aug 24 doi: 10.1007/s00167-016-4297-5. PMID: 27557796
Surgical fixation methods for tibial plateau fractures.
McNamara IR, Smith TO, Shepherd KL, Clark AB, Nielsen DM, Donell S, Hing CB
Cochrane Database Syst Rev 2015 Sep 15;2015(9):CD009679. doi: 10.1002/14651858.CD009679.pub2. PMID: 26370268Free PMC Article

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