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Unresectable Neuroendocrine Neoplasm

MedGen UID:
1712982
Concept ID:
C5239282
Neoplastic Process

Definition

A neuroendocrine neoplasm that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Chen LN, Carvajal RD
Expert Rev Anticancer Ther 2022 Oct;22(10):1017-1027. Epub 2022 Sep 19 doi: 10.1080/14737140.2022.2124971. PMID: 36102132Free PMC Article
Fishbein L, Del Rivero J, Else T, Howe JR, Asa SL, Cohen DL, Dahia PLM, Fraker DL, Goodman KA, Hope TA, Kunz PL, Perez K, Perrier ND, Pryma DA, Ryder M, Sasson AR, Soulen MC, Jimenez C
Pancreas 2021 Apr 1;50(4):469-493. doi: 10.1097/MPA.0000000000001792. PMID: 33939658

Recent clinical studies

Etiology

Ugurel S, Gutzmer R
J Dtsch Dermatol Ges 2023 Apr;21(4):343-347. Epub 2023 Mar 31 doi: 10.1111/ddg.15053. PMID: 36999586
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Sanlorenzo M, Vujic I, Posch C, Dajee A, Yen A, Kim S, Ashworth M, Rosenblum MD, Algazi A, Osella-Abate S, Quaglino P, Daud A, Ortiz-Urda S
Cancer Biol Ther 2014 Jun 1;15(6):665-74. Epub 2014 Mar 20 doi: 10.4161/cbt.28555. PMID: 24651672Free PMC Article
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ
N Engl J Med 2010 Aug 19;363(8):711-23. Epub 2010 Jun 5 doi: 10.1056/NEJMoa1003466. PMID: 20525992Free PMC Article

Diagnosis

Ugurel S, Gutzmer R
J Dtsch Dermatol Ges 2023 Apr;21(4):343-347. Epub 2023 Mar 31 doi: 10.1111/ddg.15053. PMID: 36999586
Fishbein L, Del Rivero J, Else T, Howe JR, Asa SL, Cohen DL, Dahia PLM, Fraker DL, Goodman KA, Hope TA, Kunz PL, Perez K, Perrier ND, Pryma DA, Ryder M, Sasson AR, Soulen MC, Jimenez C
Pancreas 2021 Apr 1;50(4):469-493. doi: 10.1097/MPA.0000000000001792. PMID: 33939658
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Corrie P, Hategan M, Fife K, Parkinson C
Br Med Bull 2014 Sep;111(1):149-62. doi: 10.1093/bmb/ldu019. PMID: 25190764

Therapy

Dhillon S
Drugs 2022 Apr;82(6):703-710. doi: 10.1007/s40265-022-01704-4. PMID: 35364798
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Butler MO, Hill A, Márquez-Rodas I, Haanen JBAG, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bas T, Ritchings C, Larkin J, Hodi FS
J Clin Oncol 2022 Jan 10;40(2):127-137. Epub 2021 Nov 24 doi: 10.1200/JCO.21.02229. PMID: 34818112Free PMC Article
Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinkhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C, Türeci Ö
Nature 2020 Sep;585(7823):107-112. Epub 2020 Jul 29 doi: 10.1038/s41586-020-2537-9. PMID: 32728218
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, Ferrucci PF, Hill A, Wagstaff J, Carlino MS, Haanen JB, Maio M, Marquez-Rodas I, McArthur GA, Ascierto PA, Long GV, Callahan MK, Postow MA, Grossmann K, Sznol M, Dreno B, Bastholt L, Yang A, Rollin LM, Horak C, Hodi FS, Wolchok JD
N Engl J Med 2015 Jul 2;373(1):23-34. Epub 2015 May 31 doi: 10.1056/NEJMoa1504030. PMID: 26027431Free PMC Article
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ
N Engl J Med 2010 Aug 19;363(8):711-23. Epub 2010 Jun 5 doi: 10.1056/NEJMoa1003466. PMID: 20525992Free PMC Article

Prognosis

Ugurel S, Gutzmer R
J Dtsch Dermatol Ges 2023 Apr;21(4):343-347. Epub 2023 Mar 31 doi: 10.1111/ddg.15053. PMID: 36999586
Amaria RN, Postow M, Burton EM, Tetzlaff MT, Ross MI, Torres-Cabala C, Glitza IC, Duan F, Milton DR, Busam K, Simpson L, McQuade JL, Wong MK, Gershenwald JE, Lee JE, Goepfert RP, Keung EZ, Fisher SB, Betof-Warner A, Shoushtari AN, Callahan M, Coit D, Bartlett EK, Bello D, Momtaz P, Nicholas C, Gu A, Zhang X, Korivi BR, Patnana M, Patel SP, Diab A, Lucci A, Prieto VG, Davies MA, Allison JP, Sharma P, Wargo JA, Ariyan C, Tawbi HA
Nature 2022 Nov;611(7934):155-160. Epub 2022 Oct 26 doi: 10.1038/s41586-022-05368-8. PMID: 36289334Free PMC Article
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Robert C, Grob JJ, Stroyakovskiy D, Karaszewska B, Hauschild A, Levchenko E, Chiarion Sileni V, Schachter J, Garbe C, Bondarenko I, Gogas H, Mandalá M, Haanen JBAG, Lebbé C, Mackiewicz A, Rutkowski P, Nathan PD, Ribas A, Davies MA, Flaherty KT, Burgess P, Tan M, Gasal E, Voi M, Schadendorf D, Long GV
N Engl J Med 2019 Aug 15;381(7):626-636. Epub 2019 Jun 4 doi: 10.1056/NEJMoa1904059. PMID: 31166680
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Clinical prediction guides

Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P
N Engl J Med 2023 Dec 14;389(24):2256-2266. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2304753. PMID: 37870955
Amaria RN, Postow M, Burton EM, Tetzlaff MT, Ross MI, Torres-Cabala C, Glitza IC, Duan F, Milton DR, Busam K, Simpson L, McQuade JL, Wong MK, Gershenwald JE, Lee JE, Goepfert RP, Keung EZ, Fisher SB, Betof-Warner A, Shoushtari AN, Callahan M, Coit D, Bartlett EK, Bello D, Momtaz P, Nicholas C, Gu A, Zhang X, Korivi BR, Patnana M, Patel SP, Diab A, Lucci A, Prieto VG, Davies MA, Allison JP, Sharma P, Wargo JA, Ariyan C, Tawbi HA
Nature 2022 Nov;611(7934):155-160. Epub 2022 Oct 26 doi: 10.1038/s41586-022-05368-8. PMID: 36289334Free PMC Article
Vellano CP, White MG, Andrews MC, Chelvanambi M, Witt RG, Daniele JR, Titus M, McQuade JL, Conforti F, Burton EM, Lastrapes MJ, Ologun G, Cogdill AP, Morad G, Prieto P, Lazar AJ, Chu Y, Han G, Khan MAW, Helmink B, Davies MA, Amaria RN, Kovacs JJ, Woodman SE, Patel S, Hwu P, Peoples M, Lee JE, Cooper ZA, Zhu H, Gao G, Banerjee H, Lau M, Gershenwald JE, Lucci A, Keung EZ, Ross MI, Pala L, Pagan E, Segura RL, Liu Q, Borthwick MS, Lau E, Yates MS, Westin SN, Wani K, Tetzlaff MT, Haydu LE, Mahendra M, Ma X, Logothetis C, Kulstad Z, Johnson S, Hudgens CW, Feng N, Federico L, Long GV, Futreal PA, Arur S, Tawbi HA, Moran AE, Wang L, Heffernan TP, Marszalek JR, Wargo JA
Nature 2022 Jun;606(7915):797-803. Epub 2022 Jun 15 doi: 10.1038/s41586-022-04833-8. PMID: 35705814Free PMC Article
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Butler MO, Hill A, Márquez-Rodas I, Haanen JBAG, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bas T, Ritchings C, Larkin J, Hodi FS
J Clin Oncol 2022 Jan 10;40(2):127-137. Epub 2021 Nov 24 doi: 10.1200/JCO.21.02229. PMID: 34818112Free PMC Article
Marabelle A, Fakih M, Lopez J, Shah M, Shapira-Frommer R, Nakagawa K, Chung HC, Kindler HL, Lopez-Martin JA, Miller WH Jr, Italiano A, Kao S, Piha-Paul SA, Delord JP, McWilliams RR, Fabrizio DA, Aurora-Garg D, Xu L, Jin F, Norwood K, Bang YJ
Lancet Oncol 2020 Oct;21(10):1353-1365. Epub 2020 Sep 10 doi: 10.1016/S1470-2045(20)30445-9. PMID: 32919526

Recent systematic reviews

Harrelson A, Wang R, Stewart A, Ingram C, Gillis A, Rose JB, El-Rayes B, Azmi A, Chen H
Am J Surg 2023 Nov;226(5):623-630. Epub 2023 Aug 16 doi: 10.1016/j.amjsurg.2023.08.011. PMID: 37657968
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358
Jia Z, Wang W
Eur J Radiol 2018 Mar;100:23-29. Epub 2018 Jan 9 doi: 10.1016/j.ejrad.2018.01.012. PMID: 29496075
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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