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Spitz Melanoma

MedGen UID:
1713307
•Concept ID:
C3495721
•
Neoplastic Process
Synonyms: Malignant Spitz Tumor; Spitzoid Melanoma

Definition

A melanoma that shares histopathologic and clinical features with atypical Spitz nevus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpitz Melanoma

Professional guidelines

PubMed

Benign juvenile melanoma (Spitz nevus) vs. superficial spreading malignant melanoma: criteria for histologic differentiation.
Connors RC, Chalet MD, Ackerman AB
J Dermatol Surg 1975 Jun;1(2):14-5. doi: 10.1111/j.1524-4725.1975.tb00064.x. PMID: 1223149

Recent clinical studies

Etiology

Modeling Spitz melanoma in zebrafish using sequential mutagenesis.
Mito JK, Weber MC, Corbin A, Murphy GF, Zon LI
Dis Model Mech 2022 Aug 1;15(8) Epub 2022 Aug 26 doi: 10.1242/dmm.049452. PMID: 36017742Free PMC Article
A Series of RET Fusion Spitz Neoplasms With Plaque-Like Silhouette and Dyscohesive Nesting of Epithelioid Melanocytes.
Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Gerami P
Am J Dermatopathol 2021 Apr 1;43(4):243-251. doi: 10.1097/DAD.0000000000001780. PMID: 33742998
Pediatric melanoma in the Hispanic population: An analysis of institutional and national data.
Kim DJ, Yuan TA, Chen PC, Liu-Smith F, Koh SS, Mesinkovska NA, Sarpa HG
Pediatr Dermatol 2021 Sep;38(5):1102-1110. Epub 2021 Jan 24 doi: 10.1111/pde.14516. PMID: 33486809
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Integrating Next-Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms.
Quan VL, Zhang B, Zhang Y, Mohan LS, Shi K, Wagner A, Kruse L, Taxter T, Beaubier N, White K, Zou L, Gerami P
J Invest Dermatol 2020 Aug;140(8):1599-1608. Epub 2020 Jan 29 doi: 10.1016/j.jid.2019.12.031. PMID: 32004563

Diagnosis

Spitz melanocytic tumours - a review.
Yeh I, Busam KJ
Histopathology 2022 Jan;80(1):122-134. doi: 10.1111/his.14583. PMID: 34958498
Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.
Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201Free PMC Article
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Spitz melanoma is a distinct subset of spitzoid melanoma.
Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I
Mod Pathol 2020 Jun;33(6):1122-1134. Epub 2020 Jan 3 doi: 10.1038/s41379-019-0445-z. PMID: 31900433Free PMC Article
The role of gene fusions in melanocytic neoplasms.
Quan VL, Panah E, Zhang B, Shi K, Mohan LS, Gerami P
J Cutan Pathol 2019 Nov;46(11):878-887. Epub 2019 Jun 20 doi: 10.1111/cup.13521. PMID: 31152596

Prognosis

Spitz Melanoma of Childhood With A Novel Promoter Hijacking Anaplastic Lymphoma Kinase (C2orf42-ALK) Rearrangement.
Frederico IKS, Mesbah Ardakani N, Ryan AL, Cowley MJ, Wood BA
Am J Dermatopathol 2021 Dec 1;43(12):972-975. doi: 10.1097/DAD.0000000000001972. PMID: 34001747
Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.
Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201Free PMC Article
Integrating Next-Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms.
Quan VL, Zhang B, Zhang Y, Mohan LS, Shi K, Wagner A, Kruse L, Taxter T, Beaubier N, White K, Zou L, Gerami P
J Invest Dermatol 2020 Aug;140(8):1599-1608. Epub 2020 Jan 29 doi: 10.1016/j.jid.2019.12.031. PMID: 32004563
Spitz melanoma is a distinct subset of spitzoid melanoma.
Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I
Mod Pathol 2020 Jun;33(6):1122-1134. Epub 2020 Jan 3 doi: 10.1038/s41379-019-0445-z. PMID: 31900433Free PMC Article
Global microRNA profiling for diagnostic appraisal of melanocytic Spitz tumors.
Latchana N, Regan K, Howard JH, Aldrink JH, Ranalli MA, Peters SB, Zhang X, Gru A, Payne PRO, Suarez-Kelly LP, Carson WE 3rd
J Surg Res 2016 Oct;205(2):350-358. Epub 2016 Jul 4 doi: 10.1016/j.jss.2016.06.085. PMID: 27664883Free PMC Article

Clinical prediction guides

Spitz Melanoma of Childhood With A Novel Promoter Hijacking Anaplastic Lymphoma Kinase (C2orf42-ALK) Rearrangement.
Frederico IKS, Mesbah Ardakani N, Ryan AL, Cowley MJ, Wood BA
Am J Dermatopathol 2021 Dec 1;43(12):972-975. doi: 10.1097/DAD.0000000000001972. PMID: 34001747
Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.
Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201Free PMC Article
Integrating Next-Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms.
Quan VL, Zhang B, Zhang Y, Mohan LS, Shi K, Wagner A, Kruse L, Taxter T, Beaubier N, White K, Zou L, Gerami P
J Invest Dermatol 2020 Aug;140(8):1599-1608. Epub 2020 Jan 29 doi: 10.1016/j.jid.2019.12.031. PMID: 32004563
Spitz melanoma is a distinct subset of spitzoid melanoma.
Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I
Mod Pathol 2020 Jun;33(6):1122-1134. Epub 2020 Jan 3 doi: 10.1038/s41379-019-0445-z. PMID: 31900433Free PMC Article
Pathologic Characteristics of Spitz Melanoma With MAP3K8 Fusion or Truncation in a Pediatric Cohort.
Newman S, Pappo A, Raimondi S, Zhang J, Barnhill R, Bahrami A
Am J Surg Pathol 2019 Dec;43(12):1631-1637. doi: 10.1097/PAS.0000000000001362. PMID: 31498175

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