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Unresectable Thyroid Gland Medullary Carcinoma

MedGen UID:
1713329
•Concept ID:
C5235862
•
Neoplastic Process

Definition

Thyroid gland medullary carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Thyroid Gland Medullary Carcinoma

Professional guidelines

PubMed

Radioiodine and radiotherapy in the management of thyroid cancers.
Simpson WJ
Otolaryngol Clin North Am 1990 Jun;23(3):509-21. PMID: 1694984

Recent clinical studies

Etiology

Anesthesia and Outcome of 33 Surgeries in 24 Multiple Endocrine Neoplasia Type 2A (MEN2A) Patients: A National Rare Disease Center's Experience.
Li Y, Jin D, Shen L, Huang Y
Front Endocrinol (Lausanne) 2022;13:905963. Epub 2022 Jun 30 doi: 10.3389/fendo.2022.905963. PMID: 35846296Free PMC Article
Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908
Carcinoma of the thyroid gland in Auckland, New Zealand.
Shaw JH, Dodds P
Surg Gynecol Obstet 1990 Jul;171(1):27-32. PMID: 2360146

Diagnosis

Anesthesia and Outcome of 33 Surgeries in 24 Multiple Endocrine Neoplasia Type 2A (MEN2A) Patients: A National Rare Disease Center's Experience.
Li Y, Jin D, Shen L, Huang Y
Front Endocrinol (Lausanne) 2022;13:905963. Epub 2022 Jun 30 doi: 10.3389/fendo.2022.905963. PMID: 35846296Free PMC Article
Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation.
Candanedo-Gonzalez F, Ortiz-Arce CS, Rosales-Perez S, Remirez-Castellanos AL, Cordova-Uscanga C, Gamboa-Dominguez A
Diagn Pathol 2017 Jan 14;12(1):7. doi: 10.1186/s13000-016-0595-y. PMID: 28088216Free PMC Article
Presentation of a medullary endocrine neoplasia 2A kindred with Cushing's syndrome.
Zaydfudim V, Stover DG, Caro SW, Phay JE
Am Surg 2008 Jul;74(7):659-61. PMID: 18646485
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908

Therapy

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article
Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H
BMJ Open 2018 Aug 30;8(8):e021001. doi: 10.1136/bmjopen-2017-021001. PMID: 30166292Free PMC Article
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908
Radioiodine and radiotherapy in the management of thyroid cancers.
Simpson WJ
Otolaryngol Clin North Am 1990 Jun;23(3):509-21. PMID: 1694984

Prognosis

Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H
BMJ Open 2018 Aug 30;8(8):e021001. doi: 10.1136/bmjopen-2017-021001. PMID: 30166292Free PMC Article
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908
Carcinoma of the thyroid gland in Auckland, New Zealand.
Shaw JH, Dodds P
Surg Gynecol Obstet 1990 Jul;171(1):27-32. PMID: 2360146
Radioiodine and radiotherapy in the management of thyroid cancers.
Simpson WJ
Otolaryngol Clin North Am 1990 Jun;23(3):509-21. PMID: 1694984

Clinical prediction guides

Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H
BMJ Open 2018 Aug 30;8(8):e021001. doi: 10.1136/bmjopen-2017-021001. PMID: 30166292Free PMC Article

Recent systematic reviews

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article

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