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Spiradenocylindroma

MedGen UID:
1713739
•Concept ID:
C5238477
•
Neoplastic Process

Definition

A benign adnexal neoplasm with histological features of both spiradenoma and cylindroma in a single nodular lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpiradenocylindroma

Recent clinical studies

Etiology

A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M
Am J Dermatopathol 2010 May;32(3):215-221. doi: 10.1097/DAD.0b013e3181b9678c. PMID: 20075707

Diagnosis

A rare histopathological spiradenocylindroma: a case report.
Facchini V, Colangeli W, Bozza F, Kapitonov A, Becelli R
Clin Ter 2022 Jul-Aug;173(4):292-294. doi: 10.7417/CT.2022.2433. PMID: 35857041
Giant vascular spiradenocylindroma of the scalp clinically mimicking a vascular tumor.
Daneshbod Y, Kissell J, Kerstetter J
J Cutan Pathol 2022 Apr;49(4):369-372. Epub 2021 Nov 16 doi: 10.1111/cup.14161. PMID: 34738254
Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation.
Held L, Ruetten A, Saggini A, Kempter W, Tiedke C, Weber-Kuhn S, De Saint Aubain N, Mentzel T
J Cutan Pathol 2021 Mar;48(3):384-389. Epub 2020 Nov 5 doi: 10.1111/cup.13897. PMID: 33051901
A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome.
Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV
Am J Dermatopathol 2009 Oct;31(7):642-8. doi: 10.1097/DAD.0b013e3181a1573e. PMID: 19633533

Therapy

Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M
Am J Dermatopathol 2010 May;32(3):215-221. doi: 10.1097/DAD.0b013e3181b9678c. PMID: 20075707

Prognosis

A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
Brooke-Spiegler syndrome: report of 10 patients from 8 families with novel germline mutations: evidence of diverse somatic mutations in the same patient regardless of tumor type.
Sima R, Vanecek T, Kacerovska D, Trubac P, Cribier B, Rutten A, Vazmitel M, Spagnolo DV, Litvik R, Vantuchova Y, Weyers W, Pearce RL, Pearn J, Michal M, Kazakov DV
Diagn Mol Pathol 2010 Jun;19(2):83-91. doi: 10.1097/PDM.0b013e3181ba2d96. PMID: 20502185
Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome.
Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M
Am J Surg Pathol 2009 May;33(5):705-19. doi: 10.1097/PAS.0b013e3181966762. PMID: 19194280
Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm.
Ströbel P, Zettl A, Ren Z, Starostik P, Riedmiller H, Störkel S, Müller-Hermelink HK, Marx A
Am J Surg Pathol 2002 Jan;26(1):119-24. doi: 10.1097/00000478-200201000-00016. PMID: 11756779

Clinical prediction guides

A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
Brooke-Spiegler syndrome: report of 10 patients from 8 families with novel germline mutations: evidence of diverse somatic mutations in the same patient regardless of tumor type.
Sima R, Vanecek T, Kacerovska D, Trubac P, Cribier B, Rutten A, Vazmitel M, Spagnolo DV, Litvik R, Vantuchova Y, Weyers W, Pearce RL, Pearn J, Michal M, Kazakov DV
Diagn Mol Pathol 2010 Jun;19(2):83-91. doi: 10.1097/PDM.0b013e3181ba2d96. PMID: 20502185

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