U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Post-Intensive Care Syndrome

MedGen UID:
1713999
•Concept ID:
C5391440
•
Disease or Syndrome
Synonyms: post-intensive care syndrome; postintensive care syndrome

Definition

New or worsening impairment in physical, cognitive, or mental health that occurs after treatment for a critical illness in an intensive care setting. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-Intensive Care Syndrome

Professional guidelines

PubMed

Guidelines and standards for the study of death and recalled experiences of death--a multidisciplinary consensus statement and proposed future directions.
Parnia S, Post SG, Lee MT, Lyubomirsky S, Aufderheide TP, Deakin CD, Greyson B, Long J, Gonzales AM, Huppert EL, Dickinson A, Mayer S, Locicero B, Levin J, Bossis A, Worthington E, Fenwick P, Shirazi TK
Ann N Y Acad Sci 2022 May;1511(1):5-21. Epub 2022 Feb 18 doi: 10.1111/nyas.14740. PMID: 35181885
Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.
Carod-Artal FJ
Rev Neurol 2021 Jun 1;72(11):384-396. doi: 10.33588/rn.7211.2021230. PMID: 34042167
COVID-19: ICU delirium management during SARS-CoV-2 pandemic.
Kotfis K, Williams Roberson S, Wilson JE, Dabrowski W, Pun BT, Ely EW
Crit Care 2020 Apr 28;24(1):176. doi: 10.1186/s13054-020-02882-x. PMID: 32345343Free PMC Article

Recent clinical studies

Etiology

The effects of intensive care unit-initiated transitional care interventions on elements of post-intensive care syndrome: A systematic review and meta-analysis.
Johanna Josepha Op't Hoog SA, Eskes AM, Johanna van Mersbergen-de Bruin MP, Pelgrim T, van der Hoeven H, Vermeulen H, Maria Vloet LC
Aust Crit Care 2022 May;35(3):309-320. Epub 2021 Jun 10 doi: 10.1016/j.aucc.2021.04.010. PMID: 34120805
Post Intensive Care Syndrome (PICS): an overview of the definition, etiology, risk factors, and possible counseling and treatment strategies.
Ramnarain D, Aupers E, den Oudsten B, Oldenbeuving A, de Vries J, Pouwels S
Expert Rev Neurother 2021 Oct;21(10):1159-1177. Epub 2021 Sep 22 doi: 10.1080/14737175.2021.1981289. PMID: 34519235
Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.
Carod-Artal FJ
Rev Neurol 2021 Jun 1;72(11):384-396. doi: 10.33588/rn.7211.2021230. PMID: 34042167
Risk factors for post-intensive care syndrome: A systematic review and meta-analysis.
Lee M, Kang J, Jeong YJ
Aust Crit Care 2020 May;33(3):287-294. Epub 2019 Dec 12 doi: 10.1016/j.aucc.2019.10.004. PMID: 31839375
Conceptualizing Post Intensive Care Syndrome in Children-The PICS-p Framework.
Manning JC, Pinto NP, Rennick JE, Colville G, Curley MAQ
Pediatr Crit Care Med 2018 Apr;19(4):298-300. doi: 10.1097/PCC.0000000000001476. PMID: 29406379

Diagnosis

Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial.
Seyffert S, Moiz S, Coghlan M, Balozian P, Nasser J, Rached EA, Jamil Y, Naqvi K, Rawlings L, Perkins AJ, Gao S, Hunter JD 3rd, Khan S, Heiderscheit A, Chlan LL, Khan B
Trials 2022 Jul 19;23(1):576. doi: 10.1186/s13063-022-06448-w. PMID: 35854358Free PMC Article
Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies.
Yong SJ, Liu S
Rev Med Virol 2022 Jul;32(4):e2315. Epub 2021 Dec 9 doi: 10.1002/rmv.2315. PMID: 34888989
Post-Intensive Care Syndrome in Children: A Concept Analysis.
Tang M, Xu M, Su S, Huang X, Zhang S
J Pediatr Nurs 2021 Nov-Dec;61:417-423. Epub 2021 Oct 20 doi: 10.1016/j.pedn.2021.10.007. PMID: 34687989
Incidence and influencing factors of post-intensive care cognitive impairment.
Yao L, Li Y, Yin R, Yang L, Ding N, Li B, Shen X, Zhang Z
Intensive Crit Care Nurs 2021 Dec;67:103106. Epub 2021 Jul 7 doi: 10.1016/j.iccn.2021.103106. PMID: 34246526
Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.
Carod-Artal FJ
Rev Neurol 2021 Jun 1;72(11):384-396. doi: 10.33588/rn.7211.2021230. PMID: 34042167

Therapy

Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial.
Seyffert S, Moiz S, Coghlan M, Balozian P, Nasser J, Rached EA, Jamil Y, Naqvi K, Rawlings L, Perkins AJ, Gao S, Hunter JD 3rd, Khan S, Heiderscheit A, Chlan LL, Khan B
Trials 2022 Jul 19;23(1):576. doi: 10.1186/s13063-022-06448-w. PMID: 35854358Free PMC Article
The effects of intensive care unit-initiated transitional care interventions on elements of post-intensive care syndrome: A systematic review and meta-analysis.
Johanna Josepha Op't Hoog SA, Eskes AM, Johanna van Mersbergen-de Bruin MP, Pelgrim T, van der Hoeven H, Vermeulen H, Maria Vloet LC
Aust Crit Care 2022 May;35(3):309-320. Epub 2021 Jun 10 doi: 10.1016/j.aucc.2021.04.010. PMID: 34120805
Physical Restraints and Post-Traumatic Stress Disorder in Survivors of Critical Illness. A Systematic Review and Meta-analysis.
Franks ZM, Alcock JA, Lam T, Haines KJ, Arora N, Ramanan M
Ann Am Thorac Soc 2021 Apr;18(4):689-697. doi: 10.1513/AnnalsATS.202006-738OC. PMID: 33075240
Interventions in Post-Intensive Care Syndrome-Family: A Systematic Literature Review.
Zante B, Camenisch SA, Schefold JC
Crit Care Med 2020 Sep;48(9):e835-e840. doi: 10.1097/CCM.0000000000004450. PMID: 32590386
Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis.
Fuke R, Hifumi T, Kondo Y, Hatakeyama J, Takei T, Yamakawa K, Inoue S, Nishida O
BMJ Open 2018 May 5;8(5):e019998. doi: 10.1136/bmjopen-2017-019998. PMID: 29730622Free PMC Article

Prognosis

Incidence and influencing factors of post-intensive care cognitive impairment.
Yao L, Li Y, Yin R, Yang L, Ding N, Li B, Shen X, Zhang Z
Intensive Crit Care Nurs 2021 Dec;67:103106. Epub 2021 Jul 7 doi: 10.1016/j.iccn.2021.103106. PMID: 34246526
COVID-19: from an acute to chronic disease? Potential long-term health consequences.
Higgins V, Sohaei D, Diamandis EP, Prassas I
Crit Rev Clin Lab Sci 2021 Aug;58(5):297-310. Epub 2020 Dec 21 doi: 10.1080/10408363.2020.1860895. PMID: 33347790
Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.
Mikkelsen ME, Still M, Anderson BJ, Bienvenu OJ, Brodsky MB, Brummel N, Butcher B, Clay AS, Felt H, Ferrante LE, Haines KJ, Harhay MO, Hope AA, Hopkins RO, Hosey M, Hough CTL, Jackson JC, Johnson A, Khan B, Lone NI, MacTavish P, McPeake J, Montgomery-Yates A, Needham DM, Netzer G, Schorr C, Skidmore B, Stollings JL, Umberger R, Andrews A, Iwashyna TJ, Sevin CM
Crit Care Med 2020 Nov;48(11):1670-1679. doi: 10.1097/CCM.0000000000004586. PMID: 32947467
COVID-19: ICU delirium management during SARS-CoV-2 pandemic.
Kotfis K, Williams Roberson S, Wilson JE, Dabrowski W, Pun BT, Ely EW
Crit Care 2020 Apr 28;24(1):176. doi: 10.1186/s13054-020-02882-x. PMID: 32345343Free PMC Article
Approaches to Addressing Post-Intensive Care Syndrome among Intensive Care Unit Survivors. A Narrative Review.
Brown SM, Bose S, Banner-Goodspeed V, Beesley SJ, Dinglas VD, Hopkins RO, Jackson JC, Mir-Kasimov M, Needham DM, Sevin CM; Addressing Post Intensive Care Syndrome 01 (APICS-01) study team
Ann Am Thorac Soc 2019 Aug;16(8):947-956. doi: 10.1513/AnnalsATS.201812-913FR. PMID: 31162935

Clinical prediction guides

Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial.
Seyffert S, Moiz S, Coghlan M, Balozian P, Nasser J, Rached EA, Jamil Y, Naqvi K, Rawlings L, Perkins AJ, Gao S, Hunter JD 3rd, Khan S, Heiderscheit A, Chlan LL, Khan B
Trials 2022 Jul 19;23(1):576. doi: 10.1186/s13063-022-06448-w. PMID: 35854358Free PMC Article
Incidence and influencing factors of post-intensive care cognitive impairment.
Yao L, Li Y, Yin R, Yang L, Ding N, Li B, Shen X, Zhang Z
Intensive Crit Care Nurs 2021 Dec;67:103106. Epub 2021 Jul 7 doi: 10.1016/j.iccn.2021.103106. PMID: 34246526
Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: a prospective, multicenter, observational J-PICS study.
Kawakami D, Fujitani S, Morimoto T, Dote H, Takita M, Takaba A, Hino M, Nakamura M, Irie H, Adachi T, Shibata M, Kataoka J, Korenaga A, Yamashita T, Okazaki T, Okumura M, Tsunemitsu T
Crit Care 2021 Feb 16;25(1):69. doi: 10.1186/s13054-021-03501-z. PMID: 33593406Free PMC Article
COVID-19: from an acute to chronic disease? Potential long-term health consequences.
Higgins V, Sohaei D, Diamandis EP, Prassas I
Crit Rev Clin Lab Sci 2021 Aug;58(5):297-310. Epub 2020 Dec 21 doi: 10.1080/10408363.2020.1860895. PMID: 33347790
Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.
Mikkelsen ME, Still M, Anderson BJ, Bienvenu OJ, Brodsky MB, Brummel N, Butcher B, Clay AS, Felt H, Ferrante LE, Haines KJ, Harhay MO, Hope AA, Hopkins RO, Hosey M, Hough CTL, Jackson JC, Johnson A, Khan B, Lone NI, MacTavish P, McPeake J, Montgomery-Yates A, Needham DM, Netzer G, Schorr C, Skidmore B, Stollings JL, Umberger R, Andrews A, Iwashyna TJ, Sevin CM
Crit Care Med 2020 Nov;48(11):1670-1679. doi: 10.1097/CCM.0000000000004586. PMID: 32947467

Recent systematic reviews

The effects of intensive care unit-initiated transitional care interventions on elements of post-intensive care syndrome: A systematic review and meta-analysis.
Johanna Josepha Op't Hoog SA, Eskes AM, Johanna van Mersbergen-de Bruin MP, Pelgrim T, van der Hoeven H, Vermeulen H, Maria Vloet LC
Aust Crit Care 2022 May;35(3):309-320. Epub 2021 Jun 10 doi: 10.1016/j.aucc.2021.04.010. PMID: 34120805
Physical Restraints and Post-Traumatic Stress Disorder in Survivors of Critical Illness. A Systematic Review and Meta-analysis.
Franks ZM, Alcock JA, Lam T, Haines KJ, Arora N, Ramanan M
Ann Am Thorac Soc 2021 Apr;18(4):689-697. doi: 10.1513/AnnalsATS.202006-738OC. PMID: 33075240
Interventions in Post-Intensive Care Syndrome-Family: A Systematic Literature Review.
Zante B, Camenisch SA, Schefold JC
Crit Care Med 2020 Sep;48(9):e835-e840. doi: 10.1097/CCM.0000000000004450. PMID: 32590386
Risk factors for post-intensive care syndrome: A systematic review and meta-analysis.
Lee M, Kang J, Jeong YJ
Aust Crit Care 2020 May;33(3):287-294. Epub 2019 Dec 12 doi: 10.1016/j.aucc.2019.10.004. PMID: 31839375
Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis.
Fuke R, Hifumi T, Kondo Y, Hatakeyama J, Takei T, Yamakawa K, Inoue S, Nishida O
BMJ Open 2018 May 5;8(5):e019998. doi: 10.1136/bmjopen-2017-019998. PMID: 29730622Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...