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Dysmorphic hematuria

MedGen UID:
1714149
•Concept ID:
C5397957
•
Finding
Synonym: Acanthocyturia
 
HPO: HP:0032957

Definition

The presence of dysmorphic urinary erythrocytes. This feature can be observed by phase-contrastmicroscopy, differential interference microscopy, and bright-field microscopy. The acanthocyte or G1 cell, which is a doughnut-shaped cell with one or more blebs, is reported to constitute a special form of dysmorphic erythro-cyte (D cell) specific for glomerular hematuria. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysmorphic hematuria

Professional guidelines

PubMed

Clinical Features, Treatment and Prognostic Factors of Post-Transplant Immunoglobulin A Nephropathy.
Cordeiro Cabral DB, de Sandes-Freitas TV, Medina-Pestana JO, Mastroianni-Kirsztajn G
Ann Transplant 2018 Mar 9;23:166-175. doi: 10.12659/AOT.907167. PMID: 29519995Free PMC Article

Recent clinical studies

Etiology

Thin Basement Membrane: An Underrated Cause of End-Stage Renal Disease.
Uzzo M, Moroni G, Ponticelli C
Nephron 2023;147(7):383-391. Epub 2023 Mar 7 doi: 10.1159/000528243. PMID: 36882005
Clinical and Histopathological Profile of Immunoglobulin A Nephropathy Patients in Central Part of India: A Single-Center Study.
Balwani MR, Pasari A, Bhawane A, Tolani P
Saudi J Kidney Dis Transpl 2022 Mar-Apr;33(2):307-312. doi: 10.4103/1319-2442.379029. PMID: 37417183
Clinical Features, Treatment and Prognostic Factors of Post-Transplant Immunoglobulin A Nephropathy.
Cordeiro Cabral DB, de Sandes-Freitas TV, Medina-Pestana JO, Mastroianni-Kirsztajn G
Ann Transplant 2018 Mar 9;23:166-175. doi: 10.12659/AOT.907167. PMID: 29519995Free PMC Article
Persistent glomerular hematuria in living kidney donors confers a risk of progressive kidney disease in donors after heminephrectomy.
Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S
Am J Transplant 2010 Jul;10(7):1597-604. Epub 2010 Mar 26 doi: 10.1111/j.1600-6143.2010.03077.x. PMID: 20353466
The R229Q mutation in NPHS2 may predispose to proteinuria in thin-basement-membrane nephropathy.
Tonna S, Wang YY, Wilson D, Rigby L, Tabone T, Cotton R, Savige J
Pediatr Nephrol 2008 Dec;23(12):2201-7. Epub 2008 Aug 26 doi: 10.1007/s00467-008-0934-7. PMID: 18726620

Diagnosis

Thin Basement Membrane: An Underrated Cause of End-Stage Renal Disease.
Uzzo M, Moroni G, Ponticelli C
Nephron 2023;147(7):383-391. Epub 2023 Mar 7 doi: 10.1159/000528243. PMID: 36882005
Clinical and Histopathological Profile of Immunoglobulin A Nephropathy Patients in Central Part of India: A Single-Center Study.
Balwani MR, Pasari A, Bhawane A, Tolani P
Saudi J Kidney Dis Transpl 2022 Mar-Apr;33(2):307-312. doi: 10.4103/1319-2442.379029. PMID: 37417183
Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report.
Shaojie F, Sensen S, Jingda H, Luyu W, Fei Z, Jinyu Y, Zhonggao X, Hao W
Medicine (Baltimore) 2022 Sep 16;101(37):e30686. doi: 10.1097/MD.0000000000030686. PMID: 36123857Free PMC Article
Clinical Features, Treatment and Prognostic Factors of Post-Transplant Immunoglobulin A Nephropathy.
Cordeiro Cabral DB, de Sandes-Freitas TV, Medina-Pestana JO, Mastroianni-Kirsztajn G
Ann Transplant 2018 Mar 9;23:166-175. doi: 10.12659/AOT.907167. PMID: 29519995Free PMC Article
Clinical aspects of glomerular diseases.
Glassock RJ
Am J Kidney Dis 1987 Sep;10(3):181-5. doi: 10.1016/s0272-6386(87)80172-5. PMID: 3631067

Therapy

Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report.
Shaojie F, Sensen S, Jingda H, Luyu W, Fei Z, Jinyu Y, Zhonggao X, Hao W
Medicine (Baltimore) 2022 Sep 16;101(37):e30686. doi: 10.1097/MD.0000000000030686. PMID: 36123857Free PMC Article
Clinical Features, Treatment and Prognostic Factors of Post-Transplant Immunoglobulin A Nephropathy.
Cordeiro Cabral DB, de Sandes-Freitas TV, Medina-Pestana JO, Mastroianni-Kirsztajn G
Ann Transplant 2018 Mar 9;23:166-175. doi: 10.12659/AOT.907167. PMID: 29519995Free PMC Article
Persistent glomerular hematuria in living kidney donors confers a risk of progressive kidney disease in donors after heminephrectomy.
Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S
Am J Transplant 2010 Jul;10(7):1597-604. Epub 2010 Mar 26 doi: 10.1111/j.1600-6143.2010.03077.x. PMID: 20353466

Prognosis

Thin Basement Membrane: An Underrated Cause of End-Stage Renal Disease.
Uzzo M, Moroni G, Ponticelli C
Nephron 2023;147(7):383-391. Epub 2023 Mar 7 doi: 10.1159/000528243. PMID: 36882005
Clinical and Histopathological Profile of Immunoglobulin A Nephropathy Patients in Central Part of India: A Single-Center Study.
Balwani MR, Pasari A, Bhawane A, Tolani P
Saudi J Kidney Dis Transpl 2022 Mar-Apr;33(2):307-312. doi: 10.4103/1319-2442.379029. PMID: 37417183
Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report.
Shaojie F, Sensen S, Jingda H, Luyu W, Fei Z, Jinyu Y, Zhonggao X, Hao W
Medicine (Baltimore) 2022 Sep 16;101(37):e30686. doi: 10.1097/MD.0000000000030686. PMID: 36123857Free PMC Article
Clinical Features, Treatment and Prognostic Factors of Post-Transplant Immunoglobulin A Nephropathy.
Cordeiro Cabral DB, de Sandes-Freitas TV, Medina-Pestana JO, Mastroianni-Kirsztajn G
Ann Transplant 2018 Mar 9;23:166-175. doi: 10.12659/AOT.907167. PMID: 29519995Free PMC Article
Persistent glomerular hematuria in living kidney donors confers a risk of progressive kidney disease in donors after heminephrectomy.
Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S
Am J Transplant 2010 Jul;10(7):1597-604. Epub 2010 Mar 26 doi: 10.1111/j.1600-6143.2010.03077.x. PMID: 20353466

Clinical prediction guides

Nutcracker phenomenon in combination with glomerular nephritis in isolated hematuria patients.
Ma Z, Liu X, Ning Y, Shao J, Liu W, He X
Int Urol Nephrol 2013 Jun;45(3):809-16. Epub 2012 Sep 7 doi: 10.1007/s11255-012-0265-2. PMID: 22956462
Renal involvement in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Kusaba T, Hatta T, Kimura T, Sonomura K, Tanda S, Kishimoto N, Kameyama H, Okigaki M, Mori Y, Ishigami N, Mizuno T, Nakagawa M, Matsubara H
Clin Nephrol 2007 Mar;67(3):182-7. doi: 10.5414/cnp67182. PMID: 17390743
COL4A4 mutation in thin basement membrane disease previously described in Alport syndrome.
Buzza M, Wang YY, Dagher H, Babon JJ, Cotton RG, Powell H, Dowling J, Savige J
Kidney Int 2001 Aug;60(2):480-3. doi: 10.1046/j.1523-1755.2001.060002480.x. PMID: 11473630
Dysmorphism of urinary red blood cells--value in diagnosis.
Pollock C, Liu PL, Györy AZ, Grigg R, Gallery ED, Caterson R, Ibels L, Mahony J, Waugh D
Kidney Int 1989 Dec;36(6):1045-9. doi: 10.1038/ki.1989.299. PMID: 2689749

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