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Gestational Complication

MedGen UID:
1714183
•Concept ID:
C5238706
•
Pathologic Function

Definition

A difficulty or problem that occurs during intrauterine development that can jeopardize the health of the fetus. (ACC-AHA) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational Complication

Professional guidelines

PubMed

Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary, Number 222.
Obstet Gynecol 2020 Jun;135(6):1492-1495. doi: 10.1097/AOG.0000000000003892. PMID: 32443077
Hepatitis B: Screening, Prevention, Diagnosis, and Treatment.
Wilkins T, Sams R, Carpenter M
Am Fam Physician 2019 Mar 1;99(5):314-323. PMID: 30811163
ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus.
Obstet Gynecol 2018 Feb;131(2):e49-e64. doi: 10.1097/AOG.0000000000002501. PMID: 29370047

Recent clinical studies

Etiology

A Review of the Associations Between Obstructive Sleep Apnea and Gestational Diabetes Mellitus and Possible Mechanisms of Disease.
Tong X, Yang L, Jiang C, Weng Z, Zu A, Hou Y, Fang Y, Yang W, Sun S
Reprod Sci 2023 Jan;30(1):81-92. Epub 2022 Mar 7 doi: 10.1007/s43032-022-00904-3. PMID: 35257355Free PMC Article
The Changing Climate and Pregnancy Health.
Ha S
Curr Environ Health Rep 2022 Jun;9(2):263-275. Epub 2022 Feb 22 doi: 10.1007/s40572-022-00345-9. PMID: 35194749Free PMC Article
Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice.
Oda H, Nagamatsu T, Schust DJ, Cabral H, Miyazaki T, Iriyama T, Kawana K, Osuga Y, Fujii T
Endocrinology 2021 Apr 1;162(4) doi: 10.1210/endocr/bqaa248. PMID: 33406229
Use of the Pessary in the Prevention of Preterm Delivery.
Corrêa TD, Amorim EG, Tomazelli JAG, Corrêa MD Júnior
Rev Bras Ginecol Obstet 2019 Jan;41(1):53-58. Epub 2019 Feb 4 doi: 10.1055/s-0038-1676511. PMID: 30716786Free PMC Article
Ectopic pregnancy.
Cowan BD
Curr Opin Obstet Gynecol 1993 Jun;5(3):328-32. PMID: 8329648

Diagnosis

The Changing Climate and Pregnancy Health.
Ha S
Curr Environ Health Rep 2022 Jun;9(2):263-275. Epub 2022 Feb 22 doi: 10.1007/s40572-022-00345-9. PMID: 35194749Free PMC Article
Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review.
Bastos SNMAN, Barbosa BLF, Cruz LGB, Souza RP, Silva Melo SSE, Luz CCBDS
Rev Bras Ginecol Obstet 2021 Dec;43(12):949-960. Epub 2021 Dec 21 doi: 10.1055/s-0041-1733913. PMID: 34933389Free PMC Article
EPIDEMIOLOGY OF THE PREVALENCE OF PHENOTOPIC SIGNS UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME IN WOMAN WITH MISCARRIAGES.
Ibadova TV, Maliar VV, Maliar VV, Maliar VV
Wiad Lek 2021;74(4):880-883. PMID: 34155996
Acute promyelocytic leukemia during pregnancy: A case report and 10-year institutional review of hematologic malignancies during pregnancy.
Fei F, Faye-Petersen OM, Vachhani P, Jamy O, Reddy VV
Pathol Res Pract 2019 Dec;215(12):152672. Epub 2019 Sep 28 doi: 10.1016/j.prp.2019.152672. PMID: 31587825
Ectopic pregnancy.
Cowan BD
Curr Opin Obstet Gynecol 1993 Jun;5(3):328-32. PMID: 8329648

Therapy

Adverse Childbirth and Perinatal Outcomes Among Healthy, Low-Risk Pregnant Women with Abnormal Total Gestational Weight Gain.
Ornaghi S, Fumagalli S, Galimberti S, Ornago AM, Brivio V, Lambicchi L, Nespoli A, Vergani P
J Womens Health (Larchmt) 2023 May;32(5):521-528. Epub 2023 Feb 3 doi: 10.1089/jwh.2022.0278. PMID: 36735590
Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice.
Oda H, Nagamatsu T, Schust DJ, Cabral H, Miyazaki T, Iriyama T, Kawana K, Osuga Y, Fujii T
Endocrinology 2021 Apr 1;162(4) doi: 10.1210/endocr/bqaa248. PMID: 33406229
Use of the Pessary in the Prevention of Preterm Delivery.
Corrêa TD, Amorim EG, Tomazelli JAG, Corrêa MD Júnior
Rev Bras Ginecol Obstet 2019 Jan;41(1):53-58. Epub 2019 Feb 4 doi: 10.1055/s-0038-1676511. PMID: 30716786Free PMC Article
Increased prenatal blood manganese may induce gestational blood pressure.
Vigeh M, Nishioka E, Yokoyama K, Ohtani K, Matsukawa T
Hypertens Pregnancy 2016 Nov;35(4):583-592. Epub 2016 Sep 20 doi: 10.1080/10641955.2016.1219364. PMID: 27647153
Ectopic pregnancy.
Cowan BD
Curr Opin Obstet Gynecol 1993 Jun;5(3):328-32. PMID: 8329648

Prognosis

Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia.
Wang CY, Tsai PY, Chen TY, Tsai HL, Kuo PL, Su MT
J Physiol 2019 Jun;597(12):3069-3083. Epub 2019 May 22 doi: 10.1113/JP277704. PMID: 31026335
Variations in stress levels over the course of pregnancy: factors associated with elevated hassles, state anxiety and pregnancy-specific stress.
Da Costa D, Larouche J, Dritsa M, Brender W
J Psychosom Res 1999 Dec;47(6):609-21. doi: 10.1016/s0022-3999(99)00064-1. PMID: 10661607
Ectopic pregnancy.
Cowan BD
Curr Opin Obstet Gynecol 1993 Jun;5(3):328-32. PMID: 8329648

Clinical prediction guides

Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia.
Wang CY, Tsai PY, Chen TY, Tsai HL, Kuo PL, Su MT
J Physiol 2019 Jun;597(12):3069-3083. Epub 2019 May 22 doi: 10.1113/JP277704. PMID: 31026335
TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia.
Zhang J, Dunk CE, Shynlova O, Caniggia I, Lye SJ
EBioMedicine 2019 Jan;39:531-539. Epub 2018 Dec 19 doi: 10.1016/j.ebiom.2018.12.015. PMID: 30579870Free PMC Article
A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk.
Peng S, Liu L, Zhang X, Heinrich J, Zhang J, Schramm KW, Huang Q, Tian M, Eqani SA, Shen H
Environ Health 2015 Feb 28;14:19. doi: 10.1186/s12940-015-0004-0. PMID: 25888735Free PMC Article
Chlorhexidine vaginal flushings versus systemic ampicillin in the prevention of vertical transmission of neonatal group B streptococcus, at term.
Facchinetti F, Piccinini F, Mordini B, Volpe A
J Matern Fetal Neonatal Med 2002 Feb;11(2):84-8. doi: 10.1080/jmf.11.2.84.88. PMID: 12375548
Ectopic pregnancy.
Cowan BD
Curr Opin Obstet Gynecol 1993 Jun;5(3):328-32. PMID: 8329648

Recent systematic reviews

Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review.
Bastos SNMAN, Barbosa BLF, Cruz LGB, Souza RP, Silva Melo SSE, Luz CCBDS
Rev Bras Ginecol Obstet 2021 Dec;43(12):949-960. Epub 2021 Dec 21 doi: 10.1055/s-0041-1733913. PMID: 34933389Free PMC Article

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