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t(17;19)

MedGen UID:
1714541
•Concept ID:
C5237025
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 17 and 19. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(17;19)

Professional guidelines

PubMed

Successful treatment of a chemotherapy-resistant t(17;19) paediatric ALL with a combination of inotuzumab, venetoclax and navitoclax.
Gottardi F, Baccelli F, Leardini D, Di Battista A, Castellucci P, D'Amico D, Serravalle S, Bertuccio SN, Messelodi D, Prete A, Masetti R
Br J Haematol 2023 Sep;202(5):e39-e42. Epub 2023 Jun 22 doi: 10.1111/bjh.18936. PMID: 37350036

Recent clinical studies

Etiology

Hypercalcemia and Disseminated Osteolytic Lesions With Normal Blood Counts and Absence of Circulating Blasts: A Rare Presentation of Childhood B-Lymphoblastic Leukemia.
Khayyam N, Mansoor N, Maqsood S, Jabbar N
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e301-e303. doi: 10.1097/MPH.0000000000001822. PMID: 32404687
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia.
Mathew S, Rao PH, Dalton J, Downing JR, Raimondi SC
Leukemia 2001 Mar;15(3):468-72. doi: 10.1038/sj.leu.2401989. PMID: 11237073
Adult precursor-B acute lymphoblastic leukemia with translocations involving chromosome band 19p13 is associated with poor prognosis.
Khalidi HS, O'Donnell MR, Slovak ML, Arber DA
Cancer Genet Cytogenet 1999 Feb;109(1):58-65. doi: 10.1016/s0165-4608(98)00153-8. PMID: 9973961
Translocation t(1;19)(q23;p13) in acute lymphoblastic leukemia. A report on six new cases and an unusual t(17;19)(q11;q13), with special reference to prognostic factors.
Laï JL, Fenaux P, Estienne MH, Huart JJ, Savary JB, Lepelley P, Jouet JP, Nelken B, Bauters F, Deminatti M
Cancer Genet Cytogenet 1989 Jan;37(1):9-17. doi: 10.1016/0165-4608(89)90068-x. PMID: 2917336

Diagnosis

Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K
Cancer Med 2019 Sep;8(11):5274-5288. Epub 2019 Jul 15 doi: 10.1002/cam4.2356. PMID: 31305009Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.
Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami K, Goi K, Nakamura K, Kobayashi M, Endo M, Yagita H, Kurosawa H, Thomas Look A, Honda H, Inaba T, Nakazawa S, Sugita K
Leukemia 2012 Dec;26(12):2483-93. Epub 2012 May 30 doi: 10.1038/leu.2012.139. PMID: 22743623
Congenital acute myeloid leukemia with t(8;16) and t(17;19) double translocation: case presentation and literature review.
Sung TJ, Lee DH, Kim SK, Jun YH
J Korean Med Sci 2010 Jun;25(6):945-9. Epub 2010 May 24 doi: 10.3346/jkms.2010.25.6.945. PMID: 20514319Free PMC Article
ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemia cell lines with t(17;19) and E2A-HLF expression.
Baudis M, Prima V, Tung YH, Hunger SP
Pediatr Blood Cancer 2006 Nov;47(6):757-64. doi: 10.1002/pbc.20635. PMID: 16206189

Therapy

Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K
Cancer Med 2019 Sep;8(11):5274-5288. Epub 2019 Jul 15 doi: 10.1002/cam4.2356. PMID: 31305009Free PMC Article
Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines.
Takahashi K, Inukai T, Imamura T, Yano M, Tomoyasu C, Lucas DM, Nemoto A, Sato H, Huang M, Abe M, Kagami K, Shinohara T, Watanabe A, Somazu S, Oshiro H, Akahane K, Goi K, Kikuchi J, Furukawa Y, Goto H, Minegishi M, Iwamoto S, Sugita K
PLoS One 2017;12(12):e0188680. Epub 2017 Dec 13 doi: 10.1371/journal.pone.0188680. PMID: 29236701Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Targeting survivin and p53 in pediatric acute lymphoblastic leukemia.
Tyner JW, Jemal AM, Thayer M, Druker BJ, Chang BH
Leukemia 2012 Apr;26(4):623-32. Epub 2011 Sep 30 doi: 10.1038/leu.2011.249. PMID: 21960246Free PMC Article
Translocation t(1;19)(q23;p13) in acute lymphoblastic leukemia. A report on six new cases and an unusual t(17;19)(q11;q13), with special reference to prognostic factors.
Laï JL, Fenaux P, Estienne MH, Huart JJ, Savary JB, Lepelley P, Jouet JP, Nelken B, Bauters F, Deminatti M
Cancer Genet Cytogenet 1989 Jan;37(1):9-17. doi: 10.1016/0165-4608(89)90068-x. PMID: 2917336

Prognosis

Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K
Cancer Med 2019 Sep;8(11):5274-5288. Epub 2019 Jul 15 doi: 10.1002/cam4.2356. PMID: 31305009Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.
Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami K, Goi K, Nakamura K, Kobayashi M, Endo M, Yagita H, Kurosawa H, Thomas Look A, Honda H, Inaba T, Nakazawa S, Sugita K
Leukemia 2012 Dec;26(12):2483-93. Epub 2012 May 30 doi: 10.1038/leu.2012.139. PMID: 22743623
Congenital acute myeloid leukemia with t(8;16) and t(17;19) double translocation: case presentation and literature review.
Sung TJ, Lee DH, Kim SK, Jun YH
J Korean Med Sci 2010 Jun;25(6):945-9. Epub 2010 May 24 doi: 10.3346/jkms.2010.25.6.945. PMID: 20514319Free PMC Article
ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemia cell lines with t(17;19) and E2A-HLF expression.
Baudis M, Prima V, Tung YH, Hunger SP
Pediatr Blood Cancer 2006 Nov;47(6):757-64. doi: 10.1002/pbc.20635. PMID: 16206189

Clinical prediction guides

Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K
Cancer Med 2019 Sep;8(11):5274-5288. Epub 2019 Jul 15 doi: 10.1002/cam4.2356. PMID: 31305009Free PMC Article
Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines.
Takahashi K, Inukai T, Imamura T, Yano M, Tomoyasu C, Lucas DM, Nemoto A, Sato H, Huang M, Abe M, Kagami K, Shinohara T, Watanabe A, Somazu S, Oshiro H, Akahane K, Goi K, Kikuchi J, Furukawa Y, Goto H, Minegishi M, Iwamoto S, Sugita K
PLoS One 2017;12(12):e0188680. Epub 2017 Dec 13 doi: 10.1371/journal.pone.0188680. PMID: 29236701Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K
Blood 2010 Aug 12;116(6):962-70. Epub 2010 Jun 2 doi: 10.1182/blood-2009-09-244673. PMID: 20519628
Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
Inukai T, Hirose K, Inaba T, Kurosawa H, Hama A, Inada H, Chin M, Nagatoshi Y, Ohtsuka Y, Oda M, Goto H, Endo M, Morimoto A, Imaizumi M, Kawamura N, Miyajima Y, Ohtake M, Miyaji R, Saito M, Tawa A, Yanai F, Goi K, Nakazawa S, Sugita K
Leukemia 2007 Feb;21(2):288-96. Epub 2006 Dec 21 doi: 10.1038/sj.leu.2404496. PMID: 17183364

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