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Impaired flow-mediated arterial dilatation

MedGen UID:
1714686
•Concept ID:
C5397671
•
Finding
Synonym: Endothelial dysfunction
 
HPO: HP:0032654

Definition

Flow-mediated dilatation is a noninvasive tests of endothelial function that leverages ultrasound to measure arterial diameter and its response to an increase in shear stress, which normally causes endothelium-dependent dilatation. This term pertains to an abnormal reduction in the magnitude of dilatation. Flow-mediated dilatation is usually measured at the brachial artery. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired flow-mediated arterial dilatation

Professional guidelines

PubMed

The Assessment of Endothelial Dysfunction among OSA Patients after CPAP Treatment.
Brożyna-Tkaczyk K, Myśliński W, Mosiewicz J
Medicina (Kaunas) 2021 Mar 25;57(4) doi: 10.3390/medicina57040310. PMID: 33806108Free PMC Article
Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy.
Koelwyn GJ, Lewis NC, Ellard SL, Jones LW, Gelinas JC, Rolf JD, Melzer B, Thomas SM, Douglas PS, Khouri MG, Eves ND
Oncologist 2016 Feb;21(2):141-9. Epub 2016 Jan 13 doi: 10.1634/theoncologist.2015-0352. PMID: 26764251Free PMC Article
Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis.
Orlandi M, Suvan J, Petrie A, Donos N, Masi S, Hingorani A, Deanfield J, D'Aiuto F
Atherosclerosis 2014 Sep;236(1):39-46. Epub 2014 Jun 17 doi: 10.1016/j.atherosclerosis.2014.06.002. PMID: 25014033

Recent clinical studies

Etiology

Autophagy protein 5 controls flow-dependent endothelial functions.
Nivoit P, Mathivet T, Wu J, Salemkour Y, Sankar DS, Baudrie V, Bourreau J, Guihot AL, Vessieres E, Lemitre M, Bocca C, Teillon J, Le Gall M, Chipont A, Robidel E, Dhaun N, Camerer E, Reynier P, Roux E, Couffinhal T, Hadoke PWF, Silvestre JS, Guillonneau X, Bonnin P, Henrion D, Dengjel J, Tharaux PL, Lenoir O
Cell Mol Life Sci 2023 Jul 18;80(8):210. doi: 10.1007/s00018-023-04859-9. PMID: 37460898Free PMC Article
Brachial flow-mediated dilation and carotid intima-media thickness in glaucoma patients.
Bojic L, Rogosic V, Markovic D, Rogosic LV, Glavas D
BMC Ophthalmol 2022 Jun 23;22(1):275. doi: 10.1186/s12886-022-02498-5. PMID: 35739540Free PMC Article
The Association of Flow-Mediated Dilatation and Blood Parameters in Primary Raynaud's Phenomenon.
Uzun S, Kaya İ
Int J Clin Pract 2022;2022:9347946. Epub 2022 Jan 31 doi: 10.1155/2022/9347946. PMID: 35685580Free PMC Article
Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people.
Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR
Am J Physiol Heart Circ Physiol 2020 Sep 1;319(3):H547-H556. Epub 2020 Jul 31 doi: 10.1152/ajpheart.00307.2020. PMID: 32734819Free PMC Article
Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia: A Systematic Review and Meta-Analysis.
Weissgerber TL, Milic NM, Milin-Lazovic JS, Garovic VD
Hypertension 2016 Feb;67(2):415-23. Epub 2015 Dec 28 doi: 10.1161/HYPERTENSIONAHA.115.06554. PMID: 26711737Free PMC Article

Diagnosis

The relationship between circadian rhythm of blood pressure and vascular dysfunction in essential hypertension.
Sun Y, Zhang Y, Liu F, Liu X, Hidru TH, Yang X, Jiang Y
Clin Exp Hypertens 2023 Dec 31;45(1):2229535. doi: 10.1080/10641963.2023.2229535. PMID: 37358045
Impact of Adipokines in Brachial Artery Flow-mediated Dilatation in Lupus Nephritis.
Ali AY, Abdullah H, Abdallah MFH, Fayed A
Saudi J Kidney Dis Transpl 2022 Mar-Apr;33(2):272-279. doi: 10.4103/1319-2442.379025. PMID: 37417179
Endothelial dysfunction and impaired arterial wall properties in patients with retinal vein occlusion.
Gouliopoulos N, Siasos G, Moschos MM, Oikonomou E, Rouvas A, Bletsa E, Stampouloglou P, Siasou G, Paraskevopoulos T, Vlasis K, Marinos G, Tousoulis D
Vasc Med 2020 Aug;25(4):302-308. Epub 2020 Apr 20 doi: 10.1177/1358863X20913609. PMID: 32308146
Flow-mediated dilation stimulated by sustained increases in shear stress: a useful tool for assessing endothelial function in humans?
Tremblay JC, Pyke KE
Am J Physiol Heart Circ Physiol 2018 Mar 1;314(3):H508-H520. Epub 2017 Nov 22 doi: 10.1152/ajpheart.00534.2017. PMID: 29167121Free PMC Article
Arterial stiffness and cognitive impairment.
Li X, Lyu P, Ren Y, An J, Dong Y
J Neurol Sci 2017 Sep 15;380:1-10. Epub 2017 Jun 27 doi: 10.1016/j.jns.2017.06.018. PMID: 28870545

Therapy

Prolonged impact of anti-cancer therapy on endothelial function and arterial stiffness in breast cancer patients.
Anastasiou M, Oikonomou E, Theofilis P, Papamikroulis GA, Gazouli M, Kalogeras K, Lygkoni S, Pesiridis T, Goliopoulou A, Papatheodoridi A, Psyrri A, Zagouri F, Siasos G, Tousoulis D
Vascul Pharmacol 2023 Oct;152:107195. Epub 2023 Jul 15 doi: 10.1016/j.vph.2023.107195. PMID: 37455009
Vascular Function Recovery Following Saturation Diving.
Imbert JP, Egi SM, Balestra C
Medicina (Kaunas) 2022 Oct 17;58(10) doi: 10.3390/medicina58101476. PMID: 36295636Free PMC Article
Impact of the Post-Thrombotic Syndrome on the Arterial Wall of the Lower Limbs.
Lu M, Qi X, Bi J, Li Y
Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221117473. doi: 10.1177/10760296221117473. PMID: 35924373Free PMC Article
Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome.
Jahn LA, Hartline L, Liu Z, Barrett EJ
Am J Physiol Endocrinol Metab 2022 Feb 1;322(2):E173-E180. Epub 2021 Dec 27 doi: 10.1152/ajpendo.00287.2021. PMID: 34957859Free PMC Article
Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people.
Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR
Am J Physiol Heart Circ Physiol 2020 Sep 1;319(3):H547-H556. Epub 2020 Jul 31 doi: 10.1152/ajpheart.00307.2020. PMID: 32734819Free PMC Article

Prognosis

Neuraminidase inhibition improves endothelial function in diabetic mice.
Foote CA, Ramirez-Perez FI, Smith JA, Ghiarone T, Morales-Quinones M, McMillan NJ, Augenreich MA, Power G, Burr K, Aroor AR, Bender SB, Manrique-Acevedo C, Padilla J, Martinez-Lemus LA
Am J Physiol Heart Circ Physiol 2023 Dec 1;325(6):H1337-H1353. Epub 2023 Oct 6 doi: 10.1152/ajpheart.00337.2023. PMID: 37801046Free PMC Article
The relationship between circadian rhythm of blood pressure and vascular dysfunction in essential hypertension.
Sun Y, Zhang Y, Liu F, Liu X, Hidru TH, Yang X, Jiang Y
Clin Exp Hypertens 2023 Dec 31;45(1):2229535. doi: 10.1080/10641963.2023.2229535. PMID: 37358045
Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people.
Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR
Am J Physiol Heart Circ Physiol 2020 Sep 1;319(3):H547-H556. Epub 2020 Jul 31 doi: 10.1152/ajpheart.00307.2020. PMID: 32734819Free PMC Article
Coronary Artery Disease and Endothelial Dysfunction: Novel Diagnostic and Therapeutic Approaches.
Oikonomou E, Siasos G, Tsigkou V, Bletsa E, Panoilia ME, Oikonomou IN, Simanidis I, Spinou M, Papastavrou A, Kokosias G, Zaromitidou M, Stampouloglou P, Spartalis M, Vavuranakis M, Stefanadis C, Papavassiliou AG, Tousoulis D
Curr Med Chem 2020;27(7):1052-1080. doi: 10.2174/0929867326666190830103219. PMID: 31470773
Arterial stiffness and cognitive impairment.
Li X, Lyu P, Ren Y, An J, Dong Y
J Neurol Sci 2017 Sep 15;380:1-10. Epub 2017 Jun 27 doi: 10.1016/j.jns.2017.06.018. PMID: 28870545

Clinical prediction guides

The relationship between circadian rhythm of blood pressure and vascular dysfunction in essential hypertension.
Sun Y, Zhang Y, Liu F, Liu X, Hidru TH, Yang X, Jiang Y
Clin Exp Hypertens 2023 Dec 31;45(1):2229535. doi: 10.1080/10641963.2023.2229535. PMID: 37358045
Impact of Adipokines in Brachial Artery Flow-mediated Dilatation in Lupus Nephritis.
Ali AY, Abdullah H, Abdallah MFH, Fayed A
Saudi J Kidney Dis Transpl 2022 Mar-Apr;33(2):272-279. doi: 10.4103/1319-2442.379025. PMID: 37417179
Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people.
Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR
Am J Physiol Heart Circ Physiol 2020 Sep 1;319(3):H547-H556. Epub 2020 Jul 31 doi: 10.1152/ajpheart.00307.2020. PMID: 32734819Free PMC Article
Arterial stiffness and cognitive impairment.
Li X, Lyu P, Ren Y, An J, Dong Y
J Neurol Sci 2017 Sep 15;380:1-10. Epub 2017 Jun 27 doi: 10.1016/j.jns.2017.06.018. PMID: 28870545
Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia: A Systematic Review and Meta-Analysis.
Weissgerber TL, Milic NM, Milin-Lazovic JS, Garovic VD
Hypertension 2016 Feb;67(2):415-23. Epub 2015 Dec 28 doi: 10.1161/HYPERTENSIONAHA.115.06554. PMID: 26711737Free PMC Article

Recent systematic reviews

Clinical implications of vascular dysfunction in acute and convalescent COVID-19: A systematic review.
Mavraganis G, Dimopoulou MA, Delialis D, Bampatsias D, Patras R, Sianis A, Maneta E, Stamatelopoulos K, Georgiopoulos G
Eur J Clin Invest 2022 Nov;52(11):e13859. Epub 2022 Sep 1 doi: 10.1111/eci.13859. PMID: 35986716Free PMC Article
Preclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysis.
Parolin M, Dassie F, Martini C, Mioni R, Russo L, Fallo F, Rossato M, Vettor R, Maffei P, Pagano C
Pituitary 2018 Dec;21(6):653-662. doi: 10.1007/s11102-018-0911-5. PMID: 30225826
Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia: A Systematic Review and Meta-Analysis.
Weissgerber TL, Milic NM, Milin-Lazovic JS, Garovic VD
Hypertension 2016 Feb;67(2):415-23. Epub 2015 Dec 28 doi: 10.1161/HYPERTENSIONAHA.115.06554. PMID: 26711737Free PMC Article
Subclinical atherosclerosis in Behcet's disease: A systematic review and meta-analysis.
Merashli M, Ster IC, Ames PR
Semin Arthritis Rheum 2016 Feb;45(4):502-10. Epub 2015 Jul 4 doi: 10.1016/j.semarthrit.2015.06.018. PMID: 26239908
Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis.
Masoura C, Pitsavos C, Aznaouridis K, Skoumas I, Vlachopoulos C, Stefanadis C
Atherosclerosis 2011 Jan;214(1):129-38. Epub 2010 Oct 15 doi: 10.1016/j.atherosclerosis.2010.10.008. PMID: 21074770

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