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Hyperprogression

MedGen UID:
1714714
•Concept ID:
C5236985
•
Pathologic Function

Definition

Paradoxical acceleration of tumor progression following the initiation of therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperprogression

Professional guidelines

PubMed

Non-invasive decision support for NSCLC treatment using PET/CT radiomics.
Mu W, Jiang L, Zhang J, Shi Y, Gray JE, Tunali I, Gao C, Sun Y, Tian J, Zhao X, Sun X, Gillies RJ, Schabath MB
Nat Commun 2020 Oct 16;11(1):5228. doi: 10.1038/s41467-020-19116-x. PMID: 33067442Free PMC Article
Treatment after progression in the era of immunotherapy.
Billan S, Kaidar-Person O, Gil Z
Lancet Oncol 2020 Oct;21(10):e463-e476. doi: 10.1016/S1470-2045(20)30328-4. PMID: 33002442
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576

Recent clinical studies

Etiology

Crosstalk between 5-methylcytosine and N(6)-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Tian Y, Xiao H, Yang Y, Zhang P, Yuan J, Zhang W, Chen L, Fan Y, Zhang J, Cheng H, Deng T, Yang L, Wang W, Chen G, Wang P, Gong P, Niu X, Zhang X
Mol Cancer 2023 Jan 10;22(1):5. doi: 10.1186/s12943-022-01706-6. PMID: 36627693Free PMC Article
Emerging and Evolving Concepts in Cancer Immunotherapy Imaging.
Dercle L, Sun S, Seban RD, Mekki A, Sun R, Tselikas L, Hans S, Bernard-Tessier A, Mihoubi Bouvier F, Aide N, Vercellino L, Rivas A, Girard A, Mokrane FZ, Manson G, Houot R, Lopci E, Yeh R, Ammari S, Schwartz LH
Radiology 2023 Jan;306(1):32-46. Epub 2022 Dec 6 doi: 10.1148/radiol.210518. PMID: 36472538
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer.
Hu J, Yu A, Othmane B, Qiu D, Li H, Li C, Liu P, Ren W, Chen M, Gong G, Guo X, Zhang H, Chen J, Zu X
Theranostics 2021;11(7):3089-3108. Epub 2021 Jan 1 doi: 10.7150/thno.53649. PMID: 33537076Free PMC Article
Pseudoprogression and Hyperprogression as New Forms of Response to Immunotherapy.
Frelaut M, du Rusquec P, de Moura A, Le Tourneau C, Borcoman E
BioDrugs 2020 Aug;34(4):463-476. doi: 10.1007/s40259-020-00425-y. PMID: 32394415
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576

Diagnosis

Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy.
Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer.
Hu J, Yu A, Othmane B, Qiu D, Li H, Li C, Liu P, Ren W, Chen M, Gong G, Guo X, Zhang H, Chen J, Zu X
Theranostics 2021;11(7):3089-3108. Epub 2021 Jan 1 doi: 10.7150/thno.53649. PMID: 33537076Free PMC Article
Non-invasive decision support for NSCLC treatment using PET/CT radiomics.
Mu W, Jiang L, Zhang J, Shi Y, Gray JE, Tunali I, Gao C, Sun Y, Tian J, Zhao X, Sun X, Gillies RJ, Schabath MB
Nat Commun 2020 Oct 16;11(1):5228. doi: 10.1038/s41467-020-19116-x. PMID: 33067442Free PMC Article
Treatment after progression in the era of immunotherapy.
Billan S, Kaidar-Person O, Gil Z
Lancet Oncol 2020 Oct;21(10):e463-e476. doi: 10.1016/S1470-2045(20)30328-4. PMID: 33002442
Pseudoprogression and hyperprogression in lung cancer: a comprehensive review of literature.
Zhou L, Zhang M, Li R, Xue J, Lu Y
J Cancer Res Clin Oncol 2020 Dec;146(12):3269-3279. Epub 2020 Aug 28 doi: 10.1007/s00432-020-03360-1. PMID: 32857178

Therapy

Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy.
Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
Non-invasive decision support for NSCLC treatment using PET/CT radiomics.
Mu W, Jiang L, Zhang J, Shi Y, Gray JE, Tunali I, Gao C, Sun Y, Tian J, Zhao X, Sun X, Gillies RJ, Schabath MB
Nat Commun 2020 Oct 16;11(1):5228. doi: 10.1038/s41467-020-19116-x. PMID: 33067442Free PMC Article
Treatment after progression in the era of immunotherapy.
Billan S, Kaidar-Person O, Gil Z
Lancet Oncol 2020 Oct;21(10):e463-e476. doi: 10.1016/S1470-2045(20)30328-4. PMID: 33002442
Clinical Challenges of Immune Checkpoint Inhibitors.
de Miguel M, Calvo E
Cancer Cell 2020 Sep 14;38(3):326-333. Epub 2020 Aug 3 doi: 10.1016/j.ccell.2020.07.004. PMID: 32750319
PD-1 expression and clinical PD-1 blockade in B-cell lymphomas.
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article

Prognosis

Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer.
Hu J, Yu A, Othmane B, Qiu D, Li H, Li C, Liu P, Ren W, Chen M, Gong G, Guo X, Zhang H, Chen J, Zu X
Theranostics 2021;11(7):3089-3108. Epub 2021 Jan 1 doi: 10.7150/thno.53649. PMID: 33537076Free PMC Article
Non-invasive decision support for NSCLC treatment using PET/CT radiomics.
Mu W, Jiang L, Zhang J, Shi Y, Gray JE, Tunali I, Gao C, Sun Y, Tian J, Zhao X, Sun X, Gillies RJ, Schabath MB
Nat Commun 2020 Oct 16;11(1):5228. doi: 10.1038/s41467-020-19116-x. PMID: 33067442Free PMC Article
Pseudoprogression and Hyperprogression as New Forms of Response to Immunotherapy.
Frelaut M, du Rusquec P, de Moura A, Le Tourneau C, Borcoman E
BioDrugs 2020 Aug;34(4):463-476. doi: 10.1007/s40259-020-00425-y. PMID: 32394415
Hyperprogression under Immunotherapy.
Frelaut M, Le Tourneau C, Borcoman E
Int J Mol Sci 2019 May 30;20(11) doi: 10.3390/ijms20112674. PMID: 31151303Free PMC Article
PD-1 expression and clinical PD-1 blockade in B-cell lymphomas.
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article

Clinical prediction guides

Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy.
Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer.
Hu J, Yu A, Othmane B, Qiu D, Li H, Li C, Liu P, Ren W, Chen M, Gong G, Guo X, Zhang H, Chen J, Zu X
Theranostics 2021;11(7):3089-3108. Epub 2021 Jan 1 doi: 10.7150/thno.53649. PMID: 33537076Free PMC Article
Pseudoprogression and hyperprogression in lung cancer: a comprehensive review of literature.
Zhou L, Zhang M, Li R, Xue J, Lu Y
J Cancer Res Clin Oncol 2020 Dec;146(12):3269-3279. Epub 2020 Aug 28 doi: 10.1007/s00432-020-03360-1. PMID: 32857178
Pseudoprogression and Hyperprogression as New Forms of Response to Immunotherapy.
Frelaut M, du Rusquec P, de Moura A, Le Tourneau C, Borcoman E
BioDrugs 2020 Aug;34(4):463-476. doi: 10.1007/s40259-020-00425-y. PMID: 32394415
PD-1 expression and clinical PD-1 blockade in B-cell lymphomas.
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article

Recent systematic reviews

Pseudoprogression and hyperprogression during immune checkpoint inhibitor therapy for urothelial and kidney cancer.
Soria F, Beleni AI, D'Andrea D, Resch I, Gust KM, Gontero P, Shariat SF
World J Urol 2018 Nov;36(11):1703-1709. Epub 2018 Mar 16 doi: 10.1007/s00345-018-2264-0. PMID: 29549485Free PMC Article

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