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Enlarged keratinocytes in granular or spinous layer

MedGen UID:
1715030
•Concept ID:
C5393977
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnlarged keratinocytes in granular or spinous layer

Professional guidelines

PubMed

Treatment of Combined Freckles with Chloasma Using Q-Switched 1064 nm Laser.
Zheng H, Qiao G, Zhang Y
Int J Clin Pract 2023;2023:4081427. Epub 2023 Jun 26 doi: 10.1155/2023/4081427. PMID: 37440958Free PMC Article
EGFR Signaling Is Overactive in Pachyonychia Congenita: Effective Treatment with Oral Erlotinib.
Basset J, Marchal L, Hovnanian A
J Invest Dermatol 2023 Feb;143(2):294-304.e8. Epub 2022 Sep 16 doi: 10.1016/j.jid.2022.08.045. PMID: 36116508
Evaluation of diagnostic criteria of actinic keratosis through reflectance confocal microscopy.
Nascimento Cavalleiro Macedo Mota A, Piñeiro-Maceira JM, Baptista Barcaui C
Skin Res Technol 2020 Nov;26(6):883-890. Epub 2020 Jun 25 doi: 10.1111/srt.12890. PMID: 32585761

Recent clinical studies

Etiology

Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma.
Cozma EC, Banciu LM, Soare C, Cretoiu SM
Int J Mol Sci 2023 Apr 2;24(7) doi: 10.3390/ijms24076646. PMID: 37047618Free PMC Article
Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.
Marusina AI, Ji-Xu A, Le ST, Toussi A, Tsoi LC, Li Q, Luxardi G, Nava J, Downing L, Leal AR, Kuzminykh NY, Kruglinskaya O, Brüggen MC, Adamopoulos IE, Merleev AA, Gudjonsson JE, Maverakis E
J Invest Dermatol 2023 Jul;143(7):1157-1167.e10. Epub 2023 Jan 28 doi: 10.1016/j.jid.2023.01.012. PMID: 36716917
Dermoscopy and Reflectance Confocal Microscopy in Actinic Keratosis, Intraepithelial Carcinoma, and Invasive Squamous Cell Carcinoma.
Rstom S, Abdalla B, Blumetti T, Matos L, Pinhal M, Paschoal F
J Drugs Dermatol 2022 Mar 1;21(3):259-268. doi: 10.36849/JDD.5086. PMID: 35254762
Actinic keratosis and squamous cell carcinoma: clinical and pathological features.
Filosa A, Filosa G
G Ital Dermatol Venereol 2015 Aug;150(4):379-84. Epub 2015 Jun 23 PMID: 26099352
Darier disease: A fold (intertriginous) dermatosis.
Engin B, Kutlubay Z, Erkan E, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):448-51. Epub 2015 Apr 9 doi: 10.1016/j.clindermatol.2015.04.009. PMID: 26051059

Diagnosis

Dermoscopy and Reflectance Confocal Microscopy in Actinic Keratosis, Intraepithelial Carcinoma, and Invasive Squamous Cell Carcinoma.
Rstom S, Abdalla B, Blumetti T, Matos L, Pinhal M, Paschoal F
J Drugs Dermatol 2022 Mar 1;21(3):259-268. doi: 10.36849/JDD.5086. PMID: 35254762
Hypergranulotic Dyskeratotic Acanthoma: Another Histologically Distinctive Acanthoma.
Lee SH, Griffin T, McGeehin EL, Lee JB
Am J Dermatopathol 2021 Dec 1;43(12):921-925. doi: 10.1097/DAD.0000000000001966. PMID: 33958516
Darier disease: A fold (intertriginous) dermatosis.
Engin B, Kutlubay Z, Erkan E, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):448-51. Epub 2015 Apr 9 doi: 10.1016/j.clindermatol.2015.04.009. PMID: 26051059
White lesions.
Bhattacharyya I, Chehal HK
Otolaryngol Clin North Am 2011 Feb;44(1):109-31, vi. doi: 10.1016/j.otc.2010.09.009. PMID: 21093626
Solitary epidermolytic acanthoma: a clinical and histopathological study.
Abbas O, Wieland CN, Goldberg LJ
J Eur Acad Dermatol Venereol 2011 Feb;25(2):175-80. Epub 2010 Jun 9 doi: 10.1111/j.1468-3083.2010.03736.x. PMID: 20553361

Therapy

Fucosylation deficiency enhances imiquimod-induced psoriasis-like skin inflammation by promoting CXCL1 expression.
Li N, Lee Y, Suh JH, Oh JH, Jin SP, Lee DH, Chung JH
Biochim Biophys Acta Mol Basis Dis 2024 Feb;1870(2):166988. Epub 2023 Dec 7 doi: 10.1016/j.bbadis.2023.166988. PMID: 38070583
Actinic keratosis and squamous cell carcinoma: clinical and pathological features.
Filosa A, Filosa G
G Ital Dermatol Venereol 2015 Aug;150(4):379-84. Epub 2015 Jun 23 PMID: 26099352
Darier disease: A fold (intertriginous) dermatosis.
Engin B, Kutlubay Z, Erkan E, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):448-51. Epub 2015 Apr 9 doi: 10.1016/j.clindermatol.2015.04.009. PMID: 26051059
Paraspinous muscle flaps.
Manstein ME, Manstein CH, Manstein G
Ann Plast Surg 1998 May;40(5):458-62. doi: 10.1097/00000637-199805000-00002. PMID: 9600427
Retinoid effects on the epidermis.
Elias PM
Dermatologica 1987;175 Suppl 1:28-36. doi: 10.1159/000248851. PMID: 3319727

Prognosis

Scalp trichilemmal cyst: A case report.
Zhu Z, Yang X, Fu J, Zhang S, Chong Z
Medicine (Baltimore) 2023 Jul 14;102(28):e34213. doi: 10.1097/MD.0000000000034213. PMID: 37443491Free PMC Article
Predicting spinal column profile from surface topography via 3D non-contact surface scanning.
Rayward L, Pearcy M, Izatt M, Green D, Labrom R, Askin G, Little JP
PLoS One 2023;18(3):e0282634. Epub 2023 Mar 23 doi: 10.1371/journal.pone.0282634. PMID: 36952526Free PMC Article
Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.
Hunt S, Leibner Y, Mertens EJ, Barros-Zulaica N, Kanari L, Heistek TS, Karnani MM, Aardse R, Wilbers R, Heyer DB, Goriounova NA, Verhoog MB, Testa-Silva G, Obermayer J, Versluis T, Benavides-Piccione R, de Witt-Hamer P, Idema S, Noske DP, Baayen JC, Lein ES, DeFelipe J, Markram H, Mansvelder HD, Schürmann F, Segev I, de Kock CPJ
Cereb Cortex 2023 Mar 10;33(6):2857-2878. doi: 10.1093/cercor/bhac246. PMID: 35802476Free PMC Article
Darier disease: A fold (intertriginous) dermatosis.
Engin B, Kutlubay Z, Erkan E, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):448-51. Epub 2015 Apr 9 doi: 10.1016/j.clindermatol.2015.04.009. PMID: 26051059
Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes.
Chen YW, Wang JK, Chou FP, Wu BY, Hsiao HC, Chiu H, Xu Z, Baksh ANH, Shi G, Kaul M, Barndt R, Shanmugam VK, Johnson MD, Lin CY
J Invest Dermatol 2014 Feb;134(2):405-414. Epub 2013 Jul 26 doi: 10.1038/jid.2013.320. PMID: 23900022Free PMC Article

Clinical prediction guides

Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin.
Schmitt T, Pircher J, Steinert L, Meier K, Ghoreschi K, Vielmuth F, Kugelmann D, Waschke J
Front Immunol 2022;13:884241. Epub 2022 May 25 doi: 10.3389/fimmu.2022.884241. PMID: 35711465Free PMC Article
Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis.
Das T, Zhong R, Spiotto MT
Adv Exp Med Biol 2021;1287:105-122. doi: 10.1007/978-3-030-55031-8_8. PMID: 33034029Free PMC Article
Epidermal Lamellar Granules.
Wertz P
Skin Pharmacol Physiol 2018;31(5):262-268. Epub 2018 Aug 15 doi: 10.1159/000491757. PMID: 30110701
Actinic keratosis and squamous cell carcinoma: clinical and pathological features.
Filosa A, Filosa G
G Ital Dermatol Venereol 2015 Aug;150(4):379-84. Epub 2015 Jun 23 PMID: 26099352
Solitary epidermolytic acanthoma: a clinical and histopathological study.
Abbas O, Wieland CN, Goldberg LJ
J Eur Acad Dermatol Venereol 2011 Feb;25(2):175-80. Epub 2010 Jun 9 doi: 10.1111/j.1468-3083.2010.03736.x. PMID: 20553361

Recent systematic reviews

Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review.
Salas Orozco MF, Niño-Martínez N, Martínez-Castañón GA, Patiño Marín N, Sámano Valencia C, Dipp Velázquez FA, Sosa Munguía PDC, Casillas Santana MA
Medicina (Kaunas) 2021 May 23;57(6) doi: 10.3390/medicina57060523. PMID: 34070998Free PMC Article
Histopathologic characterization of epidermolytic hyperkeratosis: a systematic review of histology from the National Registry for Ichthyosis and Related Skin Disorders.
Ross R, DiGiovanna JJ, Capaldi L, Argenyi Z, Fleckman P, Robinson-Bostom L
J Am Acad Dermatol 2008 Jul;59(1):86-90. doi: 10.1016/j.jaad.2008.02.031. PMID: 18571597Free PMC Article

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