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Metastatic Mucosal Melanoma

MedGen UID:
1715092
•Concept ID:
C5239374
•
Neoplastic Process

Definition

Mucosal melanoma that has spread from its primary site to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Mucosal Melanoma

Professional guidelines

PubMed

Toripalimab for the treatment of melanoma.
Tang B, Chi Z, Guo J
Expert Opin Biol Ther 2020 Aug;20(8):863-869. Epub 2020 May 14 doi: 10.1080/14712598.2020.1762561. PMID: 32406293

Recent clinical studies

Etiology

Toripalimab plus axitinib in patients with metastatic mucosal melanoma: 3-year survival update and biomarker analysis.
Li S, Wu X, Yan X, Zhou L, Chi Z, Si L, Cui C, Tang B, Mao L, Lian B, Wang X, Bai X, Dai J, Kong Y, Tang X, Feng H, Yao S, Flaherty KT, Guo J, Sheng X
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-004036. PMID: 35193932Free PMC Article
The efficacy of anti-programmed cell death protein 1 therapy among patients with metastatic acral and metastatic mucosal melanoma.
Ogata D, Haydu LE, Glitza IC, Patel SP, Tawbi HA, McQuade JL, Diab A, Ekmekcioglu S, Wong MK, Davies MA, Amaria RN
Cancer Med 2021 Apr;10(7):2293-2299. Epub 2021 Mar 8 doi: 10.1002/cam4.3781. PMID: 33686688Free PMC Article
Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma.
Moya-Plana A, Herrera Gómez RG, Rossoni C, Dercle L, Ammari S, Girault I, Roy S, Scoazec JY, Vagner S, Janot F, Eggermont AMM, Robert C
Cancer Immunol Immunother 2019 Jul;68(7):1171-1178. Epub 2019 Jun 7 doi: 10.1007/s00262-019-02351-7. PMID: 31172258
Li-Fraumeni syndrome presenting as mucosal melanoma: Case report and treatment considerations.
Klein JD, Kupferman ME
Head Neck 2017 Feb;39(2):E20-E22. Epub 2016 Oct 11 doi: 10.1002/hed.24594. PMID: 27726232
Metastatic mucosal melanoma: imaging patterns of metastasis and recurrence.
O'Regan K, Breen M, Ramaiya N, Jagannathan J, DiPiro PJ, Hodi FS, Van den Abbeele AD
Cancer Imaging 2013 Dec 30;13(4):626-32. doi: 10.1102/1470-7330.2013.0055. PMID: 24434078Free PMC Article

Diagnosis

Ipilimumab and nivolumab induced immune-related adverse events in metastatic mucosal melanoma.
Cao Y, Afzal MZ, Shirai K
BMJ Case Rep 2021 Aug 20;14(8) doi: 10.1136/bcr-2021-243713. PMID: 34417242Free PMC Article
Multicenter prospective phase II trial of nivolumab in patients with unresectable or metastatic mucosal melanoma.
Nomura M, Oze I, Masuishi T, Yokota T, Satake H, Iwasawa S, Kato K, Andoh M
Int J Clin Oncol 2020 May;25(5):972-977. Epub 2020 Jan 14 doi: 10.1007/s10147-020-01618-9. PMID: 31938955
Li-Fraumeni syndrome presenting as mucosal melanoma: Case report and treatment considerations.
Klein JD, Kupferman ME
Head Neck 2017 Feb;39(2):E20-E22. Epub 2016 Oct 11 doi: 10.1002/hed.24594. PMID: 27726232
Mucosal melanoma: an update.
Ballester Sánchez R, de Unamuno Bustos B, Navarro Mira M, Botella Estrada R
Actas Dermosifiliogr 2015 Mar;106(2):96-103. Epub 2014 Jul 17 doi: 10.1016/j.ad.2014.04.012. PMID: 25042176
Metastatic mucosal melanoma: imaging patterns of metastasis and recurrence.
O'Regan K, Breen M, Ramaiya N, Jagannathan J, DiPiro PJ, Hodi FS, Van den Abbeele AD
Cancer Imaging 2013 Dec 30;13(4):626-32. doi: 10.1102/1470-7330.2013.0055. PMID: 24434078Free PMC Article

Therapy

Toripalimab plus axitinib in patients with metastatic mucosal melanoma: 3-year survival update and biomarker analysis.
Li S, Wu X, Yan X, Zhou L, Chi Z, Si L, Cui C, Tang B, Mao L, Lian B, Wang X, Bai X, Dai J, Kong Y, Tang X, Feng H, Yao S, Flaherty KT, Guo J, Sheng X
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-004036. PMID: 35193932Free PMC Article
The efficacy of anti-programmed cell death protein 1 therapy among patients with metastatic acral and metastatic mucosal melanoma.
Ogata D, Haydu LE, Glitza IC, Patel SP, Tawbi HA, McQuade JL, Diab A, Ekmekcioglu S, Wong MK, Davies MA, Amaria RN
Cancer Med 2021 Apr;10(7):2293-2299. Epub 2021 Mar 8 doi: 10.1002/cam4.3781. PMID: 33686688Free PMC Article
Toripalimab for the treatment of melanoma.
Tang B, Chi Z, Guo J
Expert Opin Biol Ther 2020 Aug;20(8):863-869. Epub 2020 May 14 doi: 10.1080/14712598.2020.1762561. PMID: 32406293
Axitinib in Combination With Toripalimab, a Humanized Immunoglobulin G(4) Monoclonal Antibody Against Programmed Cell Death-1, in Patients With Metastatic Mucosal Melanoma: An Open-Label Phase IB Trial.
Sheng X, Yan X, Chi Z, Si L, Cui C, Tang B, Li S, Mao L, Lian B, Wang X, Bai X, Zhou L, Kong Y, Dai J, Wang K, Tang X, Zhou H, Wu H, Feng H, Yao S, Flaherty KT, Guo J
J Clin Oncol 2019 Nov 10;37(32):2987-2999. Epub 2019 Aug 12 doi: 10.1200/JCO.19.00210. PMID: 31403867Free PMC Article
Efficacy of immunotherapy for metastatic mucosal melanoma.
Shreders A, Joseph RW
Immunotherapy 2016 Jul;8(8):843-5. doi: 10.2217/imt-2016-0036. PMID: 27381682

Prognosis

Toripalimab plus axitinib in patients with metastatic mucosal melanoma: 3-year survival update and biomarker analysis.
Li S, Wu X, Yan X, Zhou L, Chi Z, Si L, Cui C, Tang B, Mao L, Lian B, Wang X, Bai X, Dai J, Kong Y, Tang X, Feng H, Yao S, Flaherty KT, Guo J, Sheng X
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-004036. PMID: 35193932Free PMC Article
Toripalimab for the treatment of melanoma.
Tang B, Chi Z, Guo J
Expert Opin Biol Ther 2020 Aug;20(8):863-869. Epub 2020 May 14 doi: 10.1080/14712598.2020.1762561. PMID: 32406293
Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma.
Moya-Plana A, Herrera Gómez RG, Rossoni C, Dercle L, Ammari S, Girault I, Roy S, Scoazec JY, Vagner S, Janot F, Eggermont AMM, Robert C
Cancer Immunol Immunother 2019 Jul;68(7):1171-1178. Epub 2019 Jun 7 doi: 10.1007/s00262-019-02351-7. PMID: 31172258
Li-Fraumeni syndrome presenting as mucosal melanoma: Case report and treatment considerations.
Klein JD, Kupferman ME
Head Neck 2017 Feb;39(2):E20-E22. Epub 2016 Oct 11 doi: 10.1002/hed.24594. PMID: 27726232
Biochemotherapy in patients with advanced head and neck mucosal melanoma.
Bartell HL, Bedikian AY, Papadopoulos NE, Dett TK, Ballo MT, Myers JN, Hwu P, Kim KB
Head Neck 2008 Dec;30(12):1592-8. doi: 10.1002/hed.20910. PMID: 18798304

Clinical prediction guides

Toripalimab plus axitinib in patients with metastatic mucosal melanoma: 3-year survival update and biomarker analysis.
Li S, Wu X, Yan X, Zhou L, Chi Z, Si L, Cui C, Tang B, Mao L, Lian B, Wang X, Bai X, Dai J, Kong Y, Tang X, Feng H, Yao S, Flaherty KT, Guo J, Sheng X
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-004036. PMID: 35193932Free PMC Article
Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study).
Nakamura Y, Namikawa K, Yoshikawa S, Kiniwa Y, Maekawa T, Yamasaki O, Isei T, Matsushita S, Nomura M, Nakai Y, Fukushima S, Saito S, Takenouchi T, Tanaka R, Kato H, Otsuka A, Matsuya T, Baba N, Nagase K, Inozume T, Fujimoto N, Kuwatsuka Y, Onishi M, Kaneko T, Onuma T, Umeda Y, Ogata D, Takahashi A, Otsuka M, Teramoto Y, Yamazaki N
ESMO Open 2021 Dec;6(6):100325. Epub 2021 Nov 25 doi: 10.1016/j.esmoop.2021.100325. PMID: 34839104Free PMC Article
Toripalimab for the treatment of melanoma.
Tang B, Chi Z, Guo J
Expert Opin Biol Ther 2020 Aug;20(8):863-869. Epub 2020 May 14 doi: 10.1080/14712598.2020.1762561. PMID: 32406293
Axitinib in Combination With Toripalimab, a Humanized Immunoglobulin G(4) Monoclonal Antibody Against Programmed Cell Death-1, in Patients With Metastatic Mucosal Melanoma: An Open-Label Phase IB Trial.
Sheng X, Yan X, Chi Z, Si L, Cui C, Tang B, Li S, Mao L, Lian B, Wang X, Bai X, Zhou L, Kong Y, Dai J, Wang K, Tang X, Zhou H, Wu H, Feng H, Yao S, Flaherty KT, Guo J
J Clin Oncol 2019 Nov 10;37(32):2987-2999. Epub 2019 Aug 12 doi: 10.1200/JCO.19.00210. PMID: 31403867Free PMC Article
Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma.
Moya-Plana A, Herrera Gómez RG, Rossoni C, Dercle L, Ammari S, Girault I, Roy S, Scoazec JY, Vagner S, Janot F, Eggermont AMM, Robert C
Cancer Immunol Immunother 2019 Jul;68(7):1171-1178. Epub 2019 Jun 7 doi: 10.1007/s00262-019-02351-7. PMID: 31172258

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