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Non-convulsive status epilepticus without coma

MedGen UID:
1715409
•Concept ID:
C5397684
•
Disease or Syndrome
HPO: HP:0032671

Definition

A type of status epilepticus without prominent motor symptoms in the absence of coma. [from HPO]

Professional guidelines

PubMed

Management of status epilepticus: a narrative review.
Migdady I, Rosenthal ES, Cock HR
Anaesthesia 2022 Jan;77 Suppl 1:78-91. doi: 10.1111/anae.15606. PMID: 35001380
Guidelines for the diagnosis and treatment of acute encephalopathy in childhood.
Mizuguchi M, Ichiyama T, Imataka G, Okumura A, Goto T, Sakuma H, Takanashi JI, Murayama K, Yamagata T, Yamanouchi H, Fukuda T, Maegaki Y
Brain Dev 2021 Jan;43(1):2-31. Epub 2020 Aug 20 doi: 10.1016/j.braindev.2020.08.001. PMID: 32829972
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article

Recent clinical studies

Etiology

Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Optimizing sedation in patients with acute brain injury.
Oddo M, Crippa IA, Mehta S, Menon D, Payen JF, Taccone FS, Citerio G
Crit Care 2016 May 5;20(1):128. doi: 10.1186/s13054-016-1294-5. PMID: 27145814Free PMC Article

Diagnosis

Management of status epilepticus: a narrative review.
Migdady I, Rosenthal ES, Cock HR
Anaesthesia 2022 Jan;77 Suppl 1:78-91. doi: 10.1111/anae.15606. PMID: 35001380
Guidelines for the diagnosis and treatment of acute encephalopathy in childhood.
Mizuguchi M, Ichiyama T, Imataka G, Okumura A, Goto T, Sakuma H, Takanashi JI, Murayama K, Yamagata T, Yamanouchi H, Fukuda T, Maegaki Y
Brain Dev 2021 Jan;43(1):2-31. Epub 2020 Aug 20 doi: 10.1016/j.braindev.2020.08.001. PMID: 32829972
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article

Therapy

Management of status epilepticus: a narrative review.
Migdady I, Rosenthal ES, Cock HR
Anaesthesia 2022 Jan;77 Suppl 1:78-91. doi: 10.1111/anae.15606. PMID: 35001380
Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Optimizing sedation in patients with acute brain injury.
Oddo M, Crippa IA, Mehta S, Menon D, Payen JF, Taccone FS, Citerio G
Crit Care 2016 May 5;20(1):128. doi: 10.1186/s13054-016-1294-5. PMID: 27145814Free PMC Article

Prognosis

Management of status epilepticus: a narrative review.
Migdady I, Rosenthal ES, Cock HR
Anaesthesia 2022 Jan;77 Suppl 1:78-91. doi: 10.1111/anae.15606. PMID: 35001380
Guidelines for the diagnosis and treatment of acute encephalopathy in childhood.
Mizuguchi M, Ichiyama T, Imataka G, Okumura A, Goto T, Sakuma H, Takanashi JI, Murayama K, Yamagata T, Yamanouchi H, Fukuda T, Maegaki Y
Brain Dev 2021 Jan;43(1):2-31. Epub 2020 Aug 20 doi: 10.1016/j.braindev.2020.08.001. PMID: 32829972
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article

Clinical prediction guides

Nonconvulsive status epilepticus following cardiac arrest: overlooked, untreated and misjudged.
De Stefano P, Kaplan PW, Quintard H, Seeck M, Sutter R
J Neurol 2023 Jan;270(1):130-138. Epub 2022 Sep 8 doi: 10.1007/s00415-022-11368-5. PMID: 36076090Free PMC Article
Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury.
Laing J, Gabbe B, Chen Z, Perucca P, Kwan P, O'Brien TJ
JAMA Neurol 2022 Apr 1;79(4):334-341. doi: 10.1001/jamaneurol.2021.5420. PMID: 35188950Free PMC Article
Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Clinical phenotypes within nonconvulsive status epilepticus.
Lattanzi S, Giovannini G, Brigo F, Orlandi N, Trinka E, Meletti S
Epilepsia 2021 Sep;62(9):e129-e134. Epub 2021 Jul 9 doi: 10.1111/epi.16999. PMID: 34244997Free PMC Article
Consciousness among delta waves: a paradox?
Frohlich J, Toker D, Monti MM
Brain 2021 Sep 4;144(8):2257-2277. doi: 10.1093/brain/awab095. PMID: 33693596

Recent systematic reviews

Long-term outcome of status epilepticus-related to systemic lupus erythematosus: An observational study and a systematic review.
Mikdashi J, Krumholz A
Semin Arthritis Rheum 2023 Dec;63:152250. Epub 2023 Aug 10 doi: 10.1016/j.semarthrit.2023.152250. PMID: 37595509
EEG Patterns and Outcomes After Hypoxic Brain Injury: A Systematic Review and Meta-analysis.
Perera K, Khan S, Singh S, Kromm J, Wang M, Sajobi T, Jetté N, Wiebe S, Josephson CB
Neurocrit Care 2022 Feb;36(1):292-301. Epub 2021 Aug 11 doi: 10.1007/s12028-021-01322-0. PMID: 34379270
Tiagabine-related status epilepticus: a case report and systematic literature review.
Hariri G, Ferre A, Legriel S
Acta Neurol Belg 2020 Dec;120(6):1283-1288. Epub 2020 Aug 12 doi: 10.1007/s13760-020-01464-6. PMID: 32789647
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Prognostic factors, morbidity and mortality in tonic-clonic status epilepticus: a review.
Neligan A, Shorvon SD
Epilepsy Res 2011 Jan;93(1):1-10. Epub 2010 Oct 13 doi: 10.1016/j.eplepsyres.2010.09.003. PMID: 20947300

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