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Unresectable Adenoid Cystic Carcinoma

MedGen UID:
1715623
•Concept ID:
C5235895
•
Neoplastic Process

Definition

Adenoid cystic carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Adenoid Cystic Carcinoma

Professional guidelines

PubMed

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Carcinoma of the external auditory canal: histological and treatment groups.
Hosokawa S, Mizuta K, Takahashi G, Okamura J, Takizawa Y, Hosokawa K, Yamatodani T, Mineta H
B-ENT 2014;10(4):259-64. PMID: 25654948
Differential diagnosis and treatment options in paranasal sinus cancers.
Myers LL, Oxford LE
Surg Oncol Clin N Am 2004 Jan;13(1):167-86. doi: 10.1016/S1055-3207(03)00115-7. PMID: 15062368

Recent clinical studies

Etiology

Long-term follow-up of unresectable adenoid cystic carcinoma of the trachea and bronchus treated with high-dose proton beam therapy: A report of two cases.
Nakamura M, Ohnishi K, Nakazawa K, Shimizu K, Miyauchi D, Mizumoto M, Nakai K, Okumura T, Sakurai H
Thorac Cancer 2024 Jan;15(2):201-205. Epub 2023 Nov 20 doi: 10.1111/1759-7714.15158. PMID: 37984929Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.
Eom JS, Kim B, Kim H, Jeon K, Um SW, Koh WJ, Suh GY, Chung MP, Kwon OJ
Respirology 2014 Aug;19(6):914-20. Epub 2014 Jun 17 doi: 10.1111/resp.12336. PMID: 24935759

Diagnosis

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
A multicenter phase II study of everolimus in patients with progressive unresectable adenoid cystic carcinoma.
Kim DW, Oh DY, Shin SH, Kang JH, Cho BC, Chung JS, Kim H, Park KU, Kwon JH, Han JY, Kim MJ, Bang YJ
BMC Cancer 2014 Nov 3;14:795. doi: 10.1186/1471-2407-14-795. PMID: 25362970Free PMC Article
Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.
Eom JS, Kim B, Kim H, Jeon K, Um SW, Koh WJ, Suh GY, Chung MP, Kwon OJ
Respirology 2014 Aug;19(6):914-20. Epub 2014 Jun 17 doi: 10.1111/resp.12336. PMID: 24935759
Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation.
Allen AM, Rabin MS, Reilly JJ, Mentzer SJ
J Clin Oncol 2007 Dec 1;25(34):5521-3. doi: 10.1200/JCO.2007.13.7273. PMID: 18048830

Therapy

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Phase 2 study of dovitinib in patients with metastatic or unresectable adenoid cystic carcinoma.
Keam B, Kim SB, Shin SH, Cho BC, Lee KW, Kim MK, Yun HJ, Lee SH, Yoon DH, Bang YJ
Cancer 2015 Aug 1;121(15):2612-7. Epub 2015 Apr 22 doi: 10.1002/cncr.29401. PMID: 25903089
A multicenter phase II study of everolimus in patients with progressive unresectable adenoid cystic carcinoma.
Kim DW, Oh DY, Shin SH, Kang JH, Cho BC, Chung JS, Kim H, Park KU, Kwon JH, Han JY, Kim MJ, Bang YJ
BMC Cancer 2014 Nov 3;14:795. doi: 10.1186/1471-2407-14-795. PMID: 25362970Free PMC Article
Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.
Eom JS, Kim B, Kim H, Jeon K, Um SW, Koh WJ, Suh GY, Chung MP, Kwon OJ
Respirology 2014 Aug;19(6):914-20. Epub 2014 Jun 17 doi: 10.1111/resp.12336. PMID: 24935759
Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation.
Allen AM, Rabin MS, Reilly JJ, Mentzer SJ
J Clin Oncol 2007 Dec 1;25(34):5521-3. doi: 10.1200/JCO.2007.13.7273. PMID: 18048830

Prognosis

Long-term follow-up of unresectable adenoid cystic carcinoma of the trachea and bronchus treated with high-dose proton beam therapy: A report of two cases.
Nakamura M, Ohnishi K, Nakazawa K, Shimizu K, Miyauchi D, Mizumoto M, Nakai K, Okumura T, Sakurai H
Thorac Cancer 2024 Jan;15(2):201-205. Epub 2023 Nov 20 doi: 10.1111/1759-7714.15158. PMID: 37984929Free PMC Article
Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.
Eom JS, Kim B, Kim H, Jeon K, Um SW, Koh WJ, Suh GY, Chung MP, Kwon OJ
Respirology 2014 Aug;19(6):914-20. Epub 2014 Jun 17 doi: 10.1111/resp.12336. PMID: 24935759

Clinical prediction guides

Concurrent chemoradiotherapy for locally advanced unresectable adenoid cystic carcinoma of head and neck: experience from a single institute.
Swain M, Ghosh-Laskar S, Budrukkar A, Patil R, Murthy V, Gupta T, Mummudi N, Prabhash K, Joshi A, Patil VM, Naronha V, Agarwal JP
Eur Arch Otorhinolaryngol 2021 Nov;278(11):4423-4431. Epub 2021 Feb 9 doi: 10.1007/s00405-021-06654-3. PMID: 33564909
Phase 2 study of dovitinib in patients with metastatic or unresectable adenoid cystic carcinoma.
Keam B, Kim SB, Shin SH, Cho BC, Lee KW, Kim MK, Yun HJ, Lee SH, Yoon DH, Bang YJ
Cancer 2015 Aug 1;121(15):2612-7. Epub 2015 Apr 22 doi: 10.1002/cncr.29401. PMID: 25903089
A multicenter phase II study of everolimus in patients with progressive unresectable adenoid cystic carcinoma.
Kim DW, Oh DY, Shin SH, Kang JH, Cho BC, Chung JS, Kim H, Park KU, Kwon JH, Han JY, Kim MJ, Bang YJ
BMC Cancer 2014 Nov 3;14:795. doi: 10.1186/1471-2407-14-795. PMID: 25362970Free PMC Article
Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.
Eom JS, Kim B, Kim H, Jeon K, Um SW, Koh WJ, Suh GY, Chung MP, Kwon OJ
Respirology 2014 Aug;19(6):914-20. Epub 2014 Jun 17 doi: 10.1111/resp.12336. PMID: 24935759

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