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Refractory Clear Cell Renal Cell Carcinoma

MedGen UID:
1715804
Concept ID:
C5236081
Neoplastic Process

Definition

Clear cell renal cell carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Mahmoud AM, Nabavizadeh R, Rodrigues Pessoa R, Garg I, Orme J, Costello BA, Cheville J, Lucien F
Oncologist 2023 Apr 6;28(4):297-308. doi: 10.1093/oncolo/oyac263. PMID: 36745503Free PMC Article
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Atkins MB, Philips GK
Expert Opin Emerg Drugs 2016 Sep;21(3):243-54. doi: 10.1080/14728214.2016.1226798. PMID: 27539246

Recent clinical studies

Etiology

Fong L, Hotson A, Powderly JD, Sznol M, Heist RS, Choueiri TK, George S, Hughes BGM, Hellmann MD, Shepard DR, Rini BI, Kummar S, Weise AM, Riese MJ, Markman B, Emens LA, Mahadevan D, Luke JJ, Laport G, Brody JD, Hernandez-Aya L, Bonomi P, Goldman JW, Berim L, Renouf DJ, Goodwin RA, Munneke B, Ho PY, Hsieh J, McCaffery I, Kwei L, Willingham SB, Miller RA
Cancer Discov 2020 Jan;10(1):40-53. Epub 2019 Nov 15 doi: 10.1158/2159-8290.CD-19-0980. PMID: 31732494Free PMC Article
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL
Nat Commun 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9. PMID: 30962421Free PMC Article
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P
Lancet Oncol 2016 Oct;17(10):1374-1385. Epub 2016 Sep 1 doi: 10.1016/S1470-2045(16)30364-3. PMID: 27592805Free PMC Article

Diagnosis

Yangyun W, Guowei S, Shufen S, Jie Y, Rui Y, Yu R
Gene 2022 Jan 30;809:145992. Epub 2021 Oct 11 doi: 10.1016/j.gene.2021.145992. PMID: 34648917
Sheng X, Yan X, Wang L, Shi Y, Yao X, Luo H, Shi B, Liu J, He Z, Yu G, Ying J, Han W, Hu C, Ling Y, Chi Z, Cui C, Si L, Fang J, Zhou A, Guo J
Clin Cancer Res 2021 Jan 1;27(1):43-51. Epub 2020 Oct 27 doi: 10.1158/1078-0432.CCR-20-2488. PMID: 33109737
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL
Nat Commun 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9. PMID: 30962421Free PMC Article
Chang L, Chang M, Chang HM, Chang F
Appl Immunohistochem Mol Morphol 2018 Feb;26(2):e15-e21. doi: 10.1097/PAI.0000000000000575. PMID: 28877075
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Therapy

Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Yangyun W, Guowei S, Shufen S, Jie Y, Rui Y, Yu R
Gene 2022 Jan 30;809:145992. Epub 2021 Oct 11 doi: 10.1016/j.gene.2021.145992. PMID: 34648917
Bourbon E, Ghesquières H, Bachy E
Bull Cancer 2021 Oct;108(10S):S4-S17. doi: 10.1016/j.bulcan.2021.02.017. PMID: 34920806
Fallah J, Rini BI
Curr Oncol Rep 2019 Jan 22;21(1):6. doi: 10.1007/s11912-019-0752-z. PMID: 30671662
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Prognosis

Zhao Q, Yu J, Meng X
Cancer Med 2019 Aug;8(10):4519-4526. Epub 2019 Jun 23 doi: 10.1002/cam4.2336. PMID: 31231980Free PMC Article
Fallah J, Rini BI
Curr Oncol Rep 2019 Jan 22;21(1):6. doi: 10.1007/s11912-019-0752-z. PMID: 30671662
Chang L, Chang M, Chang HM, Chang F
Appl Immunohistochem Mol Morphol 2018 Feb;26(2):e15-e21. doi: 10.1097/PAI.0000000000000575. PMID: 28877075
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P
Lancet Oncol 2016 Oct;17(10):1374-1385. Epub 2016 Sep 1 doi: 10.1016/S1470-2045(16)30364-3. PMID: 27592805Free PMC Article

Clinical prediction guides

Sheng X, Yan X, Wang L, Shi Y, Yao X, Luo H, Shi B, Liu J, He Z, Yu G, Ying J, Han W, Hu C, Ling Y, Chi Z, Cui C, Si L, Fang J, Zhou A, Guo J
Clin Cancer Res 2021 Jan 1;27(1):43-51. Epub 2020 Oct 27 doi: 10.1158/1078-0432.CCR-20-2488. PMID: 33109737
Fong L, Hotson A, Powderly JD, Sznol M, Heist RS, Choueiri TK, George S, Hughes BGM, Hellmann MD, Shepard DR, Rini BI, Kummar S, Weise AM, Riese MJ, Markman B, Emens LA, Mahadevan D, Luke JJ, Laport G, Brody JD, Hernandez-Aya L, Bonomi P, Goldman JW, Berim L, Renouf DJ, Goodwin RA, Munneke B, Ho PY, Hsieh J, McCaffery I, Kwei L, Willingham SB, Miller RA
Cancer Discov 2020 Jan;10(1):40-53. Epub 2019 Nov 15 doi: 10.1158/2159-8290.CD-19-0980. PMID: 31732494Free PMC Article
Chang L, Chang M, Chang HM, Chang F
Appl Immunohistochem Mol Morphol 2018 Feb;26(2):e15-e21. doi: 10.1097/PAI.0000000000000575. PMID: 28877075
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL
J Clin Oncol 2010 Jul 1;28(19):3167-75. Epub 2010 Jun 1 doi: 10.1200/JCO.2009.26.7609. PMID: 20516446Free PMC Article

Recent systematic reviews

Saeed A, Park R, Sun W
J Hematol Oncol 2021 Jan 12;14(1):13. doi: 10.1186/s13045-021-01034-0. PMID: 33436042Free PMC Article
Dranitsaris G, Schmitz S, Broom RJ
J Cancer Res Clin Oncol 2013 Nov;139(11):1917-26. Epub 2013 Sep 14 doi: 10.1007/s00432-013-1510-5. PMID: 24037486
Buti S, Bersanelli M, Sikokis A, Maines F, Facchinetti F, Bria E, Ardizzoni A, Tortora G, Massari F
Anticancer Drugs 2013 Jul;24(6):535-54. doi: 10.1097/CAD.0b013e3283609ec1. PMID: 23552469
Murdoch D, Sager J
Curr Opin Oncol 2008 Jan;20(1):104-11. doi: 10.1097/CCO.0b013e3282f44b12. PMID: 18043264
Coppin C, Porzsolt F, Kumpf J, Coldman A, Wilt T
Cochrane Database Syst Rev 2000;(3):CD001425. doi: 10.1002/14651858.CD001425. PMID: 10908496

Supplemental Content

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