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Pathologic Murmur

MedGen UID:
1715843
•Concept ID:
C5238836
•
Pathologic Function

Definition

A clinical finding in which turbulent flow is noted by auscultation that is associated with a structural cardiac defect. (ACC-AHA) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPathologic Murmur

Professional guidelines

PubMed

Heart Murmurs in Children: Evaluation and Management.
Ford B, Lara S, Park J
Am Fam Physician 2022 Mar 1;105(3):250-261. PMID: 35289571
Cardiac Murmurs in Children: A Challenge For The Primary Care Physician.
Kostopoulou E, Dimitriou G, Karatza A
Curr Pediatr Rev 2019;15(3):131-138. doi: 10.2174/1573396315666190321105536. PMID: 30907325
Evaluation and management of heart murmurs in children.
Frank JE, Jacobe KM
Am Fam Physician 2011 Oct 1;84(7):793-800. PMID: 22010618

Recent clinical studies

Etiology

Auscultation While Standing: A Basic and Reliable Method to Rule Out a Pathologic Heart Murmur in Children.
Lefort B, Cheyssac E, Soulé N, Poinsot J, Vaillant MC, Nassimi A, Chantepie A
Ann Fam Med 2017 Nov;15(6):523-528. doi: 10.1370/afm.2105. PMID: 29133490Free PMC Article
Appropriateness and diagnostic yield of inpatient pediatric echocardiograms.
Lang SM, Bolin E, Daily JA, Tang X, Thomas Collins R 2nd
Congenit Heart Dis 2017 Mar;12(2):210-217. Epub 2016 Nov 8 doi: 10.1111/chd.12428. PMID: 27863016
Pediatric Appropriate Use Criteria Implementation Project: A Multicenter Outpatient Echocardiography Quality Initiative.
Sachdeva R, Allen J, Benavidez OJ, Campbell RM, Douglas PS, Eidem BW, Gold L, Kelleman MS, Lopez L, McCracken CE, Stern KW, Weiner RB, Welch E, Lai WW
J Am Coll Cardiol 2015 Sep 8;66(10):1132-40. doi: 10.1016/j.jacc.2015.06.1327. PMID: 26337992
Accuracy of cardiac auscultation in asymptomatic neonates with heart murmurs: comparison between pediatric trainees and neonatologists.
Karatza AA, Fouzas S, Tzifas S, Mermiga A, Dimitriou G, Mantagos S
Pediatr Cardiol 2011 Apr;32(4):473-7. Epub 2011 Feb 17 doi: 10.1007/s00246-011-9905-z. PMID: 21327893
Evaluation of subclinical valvar disease in patients with rheumatic fever.
Ozkutlu S, Hallioglu O, Ayabakan C
Cardiol Young 2003 Dec;13(6):495-9. PMID: 14982288

Diagnosis

Heart Murmurs in Children: Evaluation and Management.
Ford B, Lara S, Park J
Am Fam Physician 2022 Mar 1;105(3):250-261. PMID: 35289571
Cardiac Murmurs in Children: A Challenge For The Primary Care Physician.
Kostopoulou E, Dimitriou G, Karatza A
Curr Pediatr Rev 2019;15(3):131-138. doi: 10.2174/1573396315666190321105536. PMID: 30907325
Teenage heart murmurs.
Naik RJ, Shah NC
Pediatr Clin North Am 2014 Feb;61(1):1-16. Epub 2013 Oct 30 doi: 10.1016/j.pcl.2013.09.014. PMID: 24267454
Evaluation and management of heart murmurs in children.
Frank JE, Jacobe KM
Am Fam Physician 2011 Oct 1;84(7):793-800. PMID: 22010618
Evaluation of children with heart murmurs.
Asprey DP
Lippincotts Prim Care Pract 1998 Sep-Oct;2(5):505-13. PMID: 9791388

Therapy

Artificial Intelligence-Assisted Auscultation of Heart Murmurs: Validation by Virtual Clinical Trial.
Thompson WR, Reinisch AJ, Unterberger MJ, Schriefl AJ
Pediatr Cardiol 2019 Mar;40(3):623-629. Epub 2018 Dec 12 doi: 10.1007/s00246-018-2036-z. PMID: 30542919
The treatment of rheumatic carditis: a review and meta-analysis.
Albert DA, Harel L, Karrison T
Medicine (Baltimore) 1995 Jan;74(1):1-12. doi: 10.1097/00005792-199501000-00001. PMID: 7837966

Prognosis

Auscultation While Standing: A Basic and Reliable Method to Rule Out a Pathologic Heart Murmur in Children.
Lefort B, Cheyssac E, Soulé N, Poinsot J, Vaillant MC, Nassimi A, Chantepie A
Ann Fam Med 2017 Nov;15(6):523-528. doi: 10.1370/afm.2105. PMID: 29133490Free PMC Article
Appropriateness and diagnostic yield of inpatient pediatric echocardiograms.
Lang SM, Bolin E, Daily JA, Tang X, Thomas Collins R 2nd
Congenit Heart Dis 2017 Mar;12(2):210-217. Epub 2016 Nov 8 doi: 10.1111/chd.12428. PMID: 27863016
Pediatric Appropriate Use Criteria Implementation Project: A Multicenter Outpatient Echocardiography Quality Initiative.
Sachdeva R, Allen J, Benavidez OJ, Campbell RM, Douglas PS, Eidem BW, Gold L, Kelleman MS, Lopez L, McCracken CE, Stern KW, Weiner RB, Welch E, Lai WW
J Am Coll Cardiol 2015 Sep 8;66(10):1132-40. doi: 10.1016/j.jacc.2015.06.1327. PMID: 26337992
Evaluation of subclinical valvar disease in patients with rheumatic fever.
Ozkutlu S, Hallioglu O, Ayabakan C
Cardiol Young 2003 Dec;13(6):495-9. PMID: 14982288
Initial evaluation of heart murmurs: are laboratory tests necessary?
Smythe JF, Teixeira OH, Vlad P, Demers PP, Feldman W
Pediatrics 1990 Oct;86(4):497-500. PMID: 2216611

Clinical prediction guides

Auscultation While Standing: A Basic and Reliable Method to Rule Out a Pathologic Heart Murmur in Children.
Lefort B, Cheyssac E, Soulé N, Poinsot J, Vaillant MC, Nassimi A, Chantepie A
Ann Fam Med 2017 Nov;15(6):523-528. doi: 10.1370/afm.2105. PMID: 29133490Free PMC Article
Appropriateness and diagnostic yield of inpatient pediatric echocardiograms.
Lang SM, Bolin E, Daily JA, Tang X, Thomas Collins R 2nd
Congenit Heart Dis 2017 Mar;12(2):210-217. Epub 2016 Nov 8 doi: 10.1111/chd.12428. PMID: 27863016
Pediatric Appropriate Use Criteria Implementation Project: A Multicenter Outpatient Echocardiography Quality Initiative.
Sachdeva R, Allen J, Benavidez OJ, Campbell RM, Douglas PS, Eidem BW, Gold L, Kelleman MS, Lopez L, McCracken CE, Stern KW, Weiner RB, Welch E, Lai WW
J Am Coll Cardiol 2015 Sep 8;66(10):1132-40. doi: 10.1016/j.jacc.2015.06.1327. PMID: 26337992
Evaluation of subclinical valvar disease in patients with rheumatic fever.
Ozkutlu S, Hallioglu O, Ayabakan C
Cardiol Young 2003 Dec;13(6):495-9. PMID: 14982288
Initial evaluation of heart murmurs: are laboratory tests necessary?
Smythe JF, Teixeira OH, Vlad P, Demers PP, Feldman W
Pediatrics 1990 Oct;86(4):497-500. PMID: 2216611

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