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Unresectable Nasopharyngeal Carcinoma

MedGen UID:
1715939
•Concept ID:
C5236962
•
Neoplastic Process

Definition

Nasopharyngeal carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Nasopharyngeal Carcinoma

Professional guidelines

PubMed

Patterns of care and treatment outcomes for local recurrence of NPC after definite IMRT-A study by the HKNPCSG.
Ng WT, Wong ECY, Cheung AKW, Chow JCH, Poon DMC, Lai JWY, Chiang CL, Choi HCW, Chau TC, Lee VHF, Lee AWM, Tam AHP, Au KH
Head Neck 2019 Oct;41(10):3661-3669. Epub 2019 Jul 27 doi: 10.1002/hed.25892. PMID: 31350940
Chemotherapy in the treatment of locally advanced head and neck cancer.
Forastiere AA
J Surg Oncol 2008 Jun 15;97(8):701-7. doi: 10.1002/jso.21012. PMID: 18493921
Chemotherapy in the management of squamous-cell carcinoma of the head and neck.
Lamont EB, Vokes EE
Lancet Oncol 2001 May;2(5):261-9. doi: 10.1016/S1470-2045(00)00320-X. PMID: 11905780

Recent clinical studies

Etiology

Is Immune Therapy Plus Chemotherapy More Effective Than Immune Therapy Alone for Unresectable Recurrent Nasopharyngeal Carcinoma?
Zhou X, Niu X, Liu P, Ou D, Zhu Y, Wang X
Front Immunol 2021;12:762663. Epub 2021 Oct 29 doi: 10.3389/fimmu.2021.762663. PMID: 34777379Free PMC Article
Stereotactic body radiotherapy and checkpoint inhibitor for locally recurrent unresectable nasopharyngeal carcinoma.
Wu JS, Jen CW, Chen HH, Cheng SH
BMJ Case Rep 2021 Jul 12;14(7) doi: 10.1136/bcr-2020-240806. PMID: 34253513Free PMC Article
Hepatic artery infusion pump for nasopharyngeal carcinoma with liver metastasis.
Peng C, Zhou C, Li G, Li H, Shi L
Clin Exp Metastasis 2020 Apr;37(2):333-339. Epub 2019 Dec 20 doi: 10.1007/s10585-019-10015-0. PMID: 31863241Free PMC Article
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Chemotherapy in the treatment of locally advanced head and neck cancer.
Forastiere AA
J Surg Oncol 2008 Jun 15;97(8):701-7. doi: 10.1002/jso.21012. PMID: 18493921

Diagnosis

The diagnosis and management of rare cystic liver metastases from nasopharyngeal carcinoma: A case report.
Liu Q, Wang J, Sun C, Xu J
Medicine (Baltimore) 2018 Jun;97(26):e11257. doi: 10.1097/MD.0000000000011257. PMID: 29952994Free PMC Article
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Myoepithelial Carcinoma of the Nasopharynx: Report of a Rare Case and a Review of the Literature.
Soon G, Petersson F
Head Neck Pathol 2015 Dec;9(4):474-80. Epub 2015 Jun 27 doi: 10.1007/s12105-015-0638-9. PMID: 26115759Free PMC Article
Diagnosis and treatment of pancreatic metastases in 22 patients: a retrospective study.
Song SW, Cheng JF, Liu N, Zhao TH
World J Surg Oncol 2014 Sep 25;12:299. doi: 10.1186/1477-7819-12-299. PMID: 25256096Free PMC Article
Prognostic factors and survival in patients with radiation-related second malignant neoplasms following radiotherapy for nasopharyngeal carcinoma.
Xi M, Liu SL, Zhao L, Shen JX, Zhang L, Zhang P, Liu MZ
PLoS One 2013;8(12):e84586. Epub 2013 Dec 18 doi: 10.1371/journal.pone.0084586. PMID: 24367679Free PMC Article

Therapy

A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
Is Immune Therapy Plus Chemotherapy More Effective Than Immune Therapy Alone for Unresectable Recurrent Nasopharyngeal Carcinoma?
Zhou X, Niu X, Liu P, Ou D, Zhu Y, Wang X
Front Immunol 2021;12:762663. Epub 2021 Oct 29 doi: 10.3389/fimmu.2021.762663. PMID: 34777379Free PMC Article
Stereotactic body radiotherapy and checkpoint inhibitor for locally recurrent unresectable nasopharyngeal carcinoma.
Wu JS, Jen CW, Chen HH, Cheng SH
BMJ Case Rep 2021 Jul 12;14(7) doi: 10.1136/bcr-2020-240806. PMID: 34253513Free PMC Article
Hepatic artery infusion pump for nasopharyngeal carcinoma with liver metastasis.
Peng C, Zhou C, Li G, Li H, Shi L
Clin Exp Metastasis 2020 Apr;37(2):333-339. Epub 2019 Dec 20 doi: 10.1007/s10585-019-10015-0. PMID: 31863241Free PMC Article
Chemotherapy in the treatment of locally advanced head and neck cancer.
Forastiere AA
J Surg Oncol 2008 Jun 15;97(8):701-7. doi: 10.1002/jso.21012. PMID: 18493921

Prognosis

A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.
Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C
Cancer Cell 2022 Sep 12;40(9):1044-1059.e8. doi: 10.1016/j.ccell.2022.08.010. PMID: 36099882
Hepatic artery infusion pump for nasopharyngeal carcinoma with liver metastasis.
Peng C, Zhou C, Li G, Li H, Shi L
Clin Exp Metastasis 2020 Apr;37(2):333-339. Epub 2019 Dec 20 doi: 10.1007/s10585-019-10015-0. PMID: 31863241Free PMC Article
Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma.
Sun Y
Mil Med Res 2019 Oct 25;6(1):32. doi: 10.1186/s40779-019-0224-7. PMID: 31651361Free PMC Article
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article

Clinical prediction guides

Is Immune Therapy Plus Chemotherapy More Effective Than Immune Therapy Alone for Unresectable Recurrent Nasopharyngeal Carcinoma?
Zhou X, Niu X, Liu P, Ou D, Zhu Y, Wang X
Front Immunol 2021;12:762663. Epub 2021 Oct 29 doi: 10.3389/fimmu.2021.762663. PMID: 34777379Free PMC Article
A Phase I Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Ipilimumab in Chinese Patients with Select Advanced Solid Tumors.
Ma Y, Fang W, Zhao H, Bathena SP, Tendolkar A, Sheng J, Zhang L
Oncologist 2021 Apr;26(4):e549-e566. Epub 2020 Nov 11 doi: 10.1002/onco.13577. PMID: 33105036Free PMC Article
Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1-Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study.
Hsu C, Lee SH, Ejadi S, Even C, Cohen RB, Le Tourneau C, Mehnert JM, Algazi A, van Brummelen EMJ, Saraf S, Thanigaimani P, Cheng JD, Hansen AR
J Clin Oncol 2017 Dec 20;35(36):4050-4056. Epub 2017 Aug 24 doi: 10.1200/JCO.2017.73.3675. PMID: 28837405
New surgical staging system for patients with recurrent nasopharyngeal carcinoma based on the AJCC/UICC rTNM classification system.
You R, Zou X, Wang SL, Jiang R, Tang LQ, Zhang WD, Li L, Zhang MX, Shen GP, Guo L, Qian CN, Mai HQ, Ma J, Hong MH, Chen MY
Eur J Cancer 2015 Sep;51(13):1771-9. Epub 2015 Jun 5 doi: 10.1016/j.ejca.2015.05.014. PMID: 26055204
Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients.
De Crevoisier R, Bourhis J, Domenge C, Wibault P, Koscielny S, Lusinchi A, Mamelle G, Janot F, Julieron M, Leridant AM, Marandas P, Armand JP, Schwaab G, Luboinski B, Eschwege F
J Clin Oncol 1998 Nov;16(11):3556-62. doi: 10.1200/JCO.1998.16.11.3556. PMID: 9817275

Recent systematic reviews

A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656

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