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Cardioinhibitory Syncope

MedGen UID:: 1716300
•Concept ID:: C5238643
•: Sign or Symptom

Definition

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and heart rate falls. (ACC-AHA) [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCardioinhibitory Syncope

Abnormality of the nervous system
- Abnormality of the peripheral nervous system
  - Abnormality of the autonomic nervous system
    - Abnormal autonomic nervous system physiology
      - Neurocirculatory asthenia
        Vasovagal syncope
        Cardioinhibitory Syncope

Professional guidelines

PubMed

Transcatheter Leadless Pacemaker for the Treatment of Vasovagal Syncope.

Kadado AJ, Gobeil K, Motta J, Chalhoub F
Crit Pathw Cardiol 2023 Sep 1;22(3):88-90. Epub 2023 May 31 doi: 10.1097/HPC.0000000000000325. PMID: 37249900

Cardioinhibitory syncope: from pathophysiology to treatment-should we think on cardioneuroablation?

Garcia A, Marquez MF, Fierro EF, Baez JJ, Rockbrand LP, Gomez-Flores J
J Interv Card Electrophysiol 2020 Nov;59(2):441-461. Epub 2020 May 7 doi: 10.1007/s10840-020-00758-2. PMID: 32377918

Implantable rhythm devices in the management of vasovagal syncope.

Solbiati M, Sheldon RS
Auton Neurosci 2014 Sep;184:33-9. Epub 2014 May 27 doi: 10.1016/j.autneu.2014.05.012. PMID: 24916847

See all (3)

Recent clinical studies

Etiology

Transcatheter Leadless Pacemaker for the Treatment of Vasovagal Syncope.

Kadado AJ, Gobeil K, Motta J, Chalhoub F
Crit Pathw Cardiol 2023 Sep 1;22(3):88-90. Epub 2023 May 31 doi: 10.1097/HPC.0000000000000325. PMID: 37249900

Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.

Russo V, Parente E, Rago A, Comune A, Laezza N, Papa AA, Chamberland C, Huynh T, Golino P, Brignole M, Nigro G
Clin Auton Res 2022 Jun;32(3):167-173. Epub 2022 May 6 doi: 10.1007/s10286-022-00864-3. PMID: 35524080 Free PMC Article

Cardioinhibitory syncope: from pathophysiology to treatment-should we think on cardioneuroablation?

Garcia A, Marquez MF, Fierro EF, Baez JJ, Rockbrand LP, Gomez-Flores J
J Interv Card Electrophysiol 2020 Nov;59(2):441-461. Epub 2020 May 7 doi: 10.1007/s10840-020-00758-2. PMID: 32377918

Does A Therapy for Reflex Vasovagal Syncope Really Exist?

Romano S, Branz L, Fondrieschi L, Minuz P
High Blood Press Cardiovasc Prev 2019 Aug;26(4):273-281. Epub 2019 Jul 11 doi: 10.1007/s40292-019-00327-3. PMID: 31297720

Cardiac pacing in cardioinhibitory syncope in children.

Paech C, Wagner F, Mensch S, Antonin Gebauer R
Congenit Heart Dis 2018 Nov;13(6):1064-1068. Epub 2018 Oct 9 doi: 10.1111/chd.12682. PMID: 30298977

See all (26)

Diagnosis

Transcatheter Leadless Pacemaker for the Treatment of Vasovagal Syncope.

Kadado AJ, Gobeil K, Motta J, Chalhoub F
Crit Pathw Cardiol 2023 Sep 1;22(3):88-90. Epub 2023 May 31 doi: 10.1097/HPC.0000000000000325. PMID: 37249900

Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.

Cardioinhibitory syncope: from pathophysiology to treatment-should we think on cardioneuroablation?

Garcia A, Marquez MF, Fierro EF, Baez JJ, Rockbrand LP, Gomez-Flores J
J Interv Card Electrophysiol 2020 Nov;59(2):441-461. Epub 2020 May 7 doi: 10.1007/s10840-020-00758-2. PMID: 32377918

Does A Therapy for Reflex Vasovagal Syncope Really Exist?

Romano S, Branz L, Fondrieschi L, Minuz P
High Blood Press Cardiovasc Prev 2019 Aug;26(4):273-281. Epub 2019 Jul 11 doi: 10.1007/s40292-019-00327-3. PMID: 31297720

Cardiac pacing in cardioinhibitory syncope in children.

Paech C, Wagner F, Mensch S, Antonin Gebauer R
Congenit Heart Dis 2018 Nov;13(6):1064-1068. Epub 2018 Oct 9 doi: 10.1111/chd.12682. PMID: 30298977

See all (29)

Therapy

Glossopharyngeal neuralgia with cardioinhibitory syncope: Is a permanent pacemaker required?

Marques A, Caldeira D, Alegria S, Pereira AR, João I, Pereira H
Rev Port Cardiol 2023 Sep;42(9):805-809. Epub 2023 Apr 3 doi: 10.1016/j.repc.2019.12.013. PMID: 37019279

Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.

Cardioinhibitory syncope: from pathophysiology to treatment-should we think on cardioneuroablation?

Garcia A, Marquez MF, Fierro EF, Baez JJ, Rockbrand LP, Gomez-Flores J
J Interv Card Electrophysiol 2020 Nov;59(2):441-461. Epub 2020 May 7 doi: 10.1007/s10840-020-00758-2. PMID: 32377918

Implantable rhythm devices in the management of vasovagal syncope.

Solbiati M, Sheldon RS
Auton Neurosci 2014 Sep;184:33-9. Epub 2014 May 27 doi: 10.1016/j.autneu.2014.05.012. PMID: 24916847

The medical therapy of cardioinhibitory syncope in pediatric patients.

Deal BJ, Strieper M, Scagliotti D, Hulse E, Auld D, Campbell R, Strasburger JF, Benson DW Jr
Pacing Clin Electrophysiol 1997 Jul;20(7):1759-61. doi: 10.1111/j.1540-8159.1997.tb03563.x. PMID: 9249828

See all (13)

Prognosis

Glyceryl trinitrate-induced blood pressure variability decrease during head-up tilt test predicts vasovagal response.

Meglič B, Danieli A
Blood Press Monit 2023 Oct 1;28(5):236-243. Epub 2023 Jun 19 doi: 10.1097/MBP.0000000000000653. PMID: 37334541

The clinical presentation of syncope influences the head-up tilt test responses.

Russo V, Parente E, Comune A, Laezza N, Rago A, Golino P, Nigro G, Brignole M
Eur J Intern Med 2023 Apr;110:41-47. Epub 2023 Jan 11 doi: 10.1016/j.ejim.2023.01.001. PMID: 36639324

Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.

Cardiac pacing in cardioinhibitory syncope in children.

Paech C, Wagner F, Mensch S, Antonin Gebauer R
Congenit Heart Dis 2018 Nov;13(6):1064-1068. Epub 2018 Oct 9 doi: 10.1111/chd.12682. PMID: 30298977

Is heart rate recovery index a predictive factor for cardioinhibitory syncope?

Emren V, Kocabaş U
Kardiol Pol 2018;76(2):347-352. Epub 2017 Dec 1 doi: 10.5603/KP.a2017.0228. PMID: 29192954

See all (14)

Clinical prediction guides

Glyceryl trinitrate-induced blood pressure variability decrease during head-up tilt test predicts vasovagal response.

Meglič B, Danieli A
Blood Press Monit 2023 Oct 1;28(5):236-243. Epub 2023 Jun 19 doi: 10.1097/MBP.0000000000000653. PMID: 37334541

The clinical presentation of syncope influences the head-up tilt test responses.

Russo V, Parente E, Comune A, Laezza N, Rago A, Golino P, Nigro G, Brignole M
Eur J Intern Med 2023 Apr;110:41-47. Epub 2023 Jan 11 doi: 10.1016/j.ejim.2023.01.001. PMID: 36639324

Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.

Prevalence and One-year Outcome of Carotid Sinus Hypersensitivity in Unexplained Syncope: A Prospective Cohort Study from South India.

Kadermuneer P, Sandeep R, Haridasan V, George B, Sajeev CG, Krishnan MN
Indian Heart J 2019 Jan-Feb;71(1):1-6. Epub 2019 Jan 30 doi: 10.1016/j.ihj.2019.01.004. PMID: 31000176 Free PMC Article

Is heart rate recovery index a predictive factor for cardioinhibitory syncope?

Emren V, Kocabaş U
Kardiol Pol 2018;76(2):347-352. Epub 2017 Dec 1 doi: 10.5603/KP.a2017.0228. PMID: 29192954

See all (11)

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Cardioinhibitory Syncope

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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