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Refractory Metastatic Pancreatic Adenocarcinoma

MedGen UID:
1716602
•Concept ID:
C5238966
•
Neoplastic Process

Definition

Metastatic pancreatic adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Metastatic Pancreatic Adenocarcinoma

Professional guidelines

PubMed

Camrelizumab and metronomic capecitabine for patients with treatment-refractory solid tumors (McCREST trial).
Zhou C, Shangguan C, Shi M, Xi W, Wu J, Yang H, Guo L, Cai Q, Shi Y, Liu J, Zhang J
Future Oncol 2022 Jul;18(23):2495-2503. Epub 2022 Jun 15 doi: 10.2217/fon-2021-1579. PMID: 35703115
Liposomal Irinotecan in the Treatment of Refractory Pancreatic Cancer.
Bien H, Mackenzie GG, Choi M
Recent Pat Anticancer Drug Discov 2016;11(4):376-383. doi: 10.2174/1574892811666160729094415. PMID: 27480831
Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma.
Weinberg BA, Yabar CS, Brody JR, Pishvaian MJ
Oncology (Williston Park) 2015 Nov;29(11):809-20, 886. PMID: 26573060

Recent clinical studies

Etiology

A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma.
Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Pembrolizumab Plus Axitinib for Metastatic Papillary and Chromophobe Renal Cell Carcinoma: NEMESIA (Non Clear MEtaStatic Renal Cell Carcinoma Pembrolizumab Axitinib) Study, a Subgroup Analysis of I-RARE Observational Study (Meet-URO 23a).
Stellato M, Buti S, Maruzzo M, Bersanelli M, Pierantoni F, De Giorgi U, Di Napoli M, Iacovelli R, Vitale MG, Ermacora P, Malgeri A, Maiorano BA, Prati V, Mennitto A, Cavo A, Santoni M, Carella C, Fratino L, Procopio G, Verzoni E, Santini D
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021096. PMID: 36674615Free PMC Article
Characterization of Blood-Based Molecular Profiling in Pancreatic Adenocarcinoma.
Chung C, Galvin R, Achenbach E, Dziadkowiec O, Sen S
Oncology (Williston Park) 2021 Dec 23;35(12):794-803. doi: 10.46883/2021.25920931. PMID: 35089001
Nanoliposomal irinotecan plus fluorouracil and folinic acid as a second-line treatment option in patients with metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study.
Park SJ, Kim H, Shin K, Hong TH, Suh JH, Lee MA
BMC Cancer 2021 Nov 3;21(1):1176. doi: 10.1186/s12885-021-08887-1. PMID: 34732161Free PMC Article
Molecular Profiling Practices in Pancreatic Adenocarcinoma: Academic vs Community Physicians.
Chung C, Galvin R, Achenbach E, Dziadkowiec O, Sen S
Oncology (Williston Park) 2021 May 12;35(5):244-248. doi: 10.46883/ONC.2021.3505.0244. PMID: 33979117

Diagnosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
A review study on early detection of pancreatic ductal adenocarcinoma using artificial intelligence assisted diagnostic methods.
Sijithra PC, Santhi N, Ramasamy N
Eur J Radiol 2023 Sep;166:110972. Epub 2023 Jul 11 doi: 10.1016/j.ejrad.2023.110972. PMID: 37454557
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA-Associated Pancreatic Cancer in the Clinical and Preclinical Setting.
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, Moran-Jones K, Dorrell C, Sears RC, Kuo C, Han H, Biankin A, Grandori C, Von Hoff DD, Kemp CJ
Cancer Res 2022 Sep 16;82(18):3375-3393. doi: 10.1158/0008-5472.CAN-21-4222. PMID: 35819261Free PMC Article
Altered glycosylation in pancreatic cancer and beyond.
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article

Therapy

Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA-Associated Pancreatic Cancer in the Clinical and Preclinical Setting.
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Emerging therapies for advanced insulinomas and glucagonomas.
Alexandraki KI, Kaltsas GA, Grozinsky-Glasberg S
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Aug 7 doi: 10.1530/ERC-23-0020. PMID: 37343152
Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase I/II IMMU-132-01 basket trial.
Bardia A, Messersmith WA, Kio EA, Berlin JD, Vahdat L, Masters GA, Moroose R, Santin AD, Kalinsky K, Picozzi V, O'Shaughnessy J, Gray JE, Komiya T, Lang JM, Chang JC, Starodub A, Goldenberg DM, Sharkey RM, Maliakal P, Hong Q, Wegener WA, Goswami T, Ocean AJ
Ann Oncol 2021 Jun;32(6):746-756. Epub 2021 Mar 16 doi: 10.1016/j.annonc.2021.03.005. PMID: 33741442
Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.
Beatty GL, O'Hara MH, Lacey SF, Torigian DA, Nazimuddin F, Chen F, Kulikovskaya IM, Soulen MC, McGarvey M, Nelson AM, Gladney WL, Levine BL, Melenhorst JJ, Plesa G, June CH
Gastroenterology 2018 Jul;155(1):29-32. Epub 2018 Mar 20 doi: 10.1053/j.gastro.2018.03.029. PMID: 29567081Free PMC Article
Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma.
Weinberg BA, Yabar CS, Brody JR, Pishvaian MJ
Oncology (Williston Park) 2015 Nov;29(11):809-20, 886. PMID: 26573060

Prognosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Altered glycosylation in pancreatic cancer and beyond.
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article
Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome.
Liudahl SM, Betts CB, Sivagnanam S, Morales-Oyarvide V, da Silva A, Yuan C, Hwang S, Grossblatt-Wait A, Leis KR, Larson W, Lavoie MB, Robinson P, Dias Costa A, Väyrynen SA, Clancy TE, Rubinson DA, Link J, Keith D, Horton W, Tempero MA, Vonderheide RH, Jaffee EM, Sheppard B, Goecks J, Sears RC, Park BS, Mori M, Nowak JA, Wolpin BM, Coussens LM
Cancer Discov 2021 Aug;11(8):2014-2031. Epub 2021 Mar 16 doi: 10.1158/2159-8290.CD-20-0841. PMID: 33727309Free PMC Article
Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.
Beatty GL, O'Hara MH, Lacey SF, Torigian DA, Nazimuddin F, Chen F, Kulikovskaya IM, Soulen MC, McGarvey M, Nelson AM, Gladney WL, Levine BL, Melenhorst JJ, Plesa G, June CH
Gastroenterology 2018 Jul;155(1):29-32. Epub 2018 Mar 20 doi: 10.1053/j.gastro.2018.03.029. PMID: 29567081Free PMC Article
Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma.
Weinberg BA, Yabar CS, Brody JR, Pishvaian MJ
Oncology (Williston Park) 2015 Nov;29(11):809-20, 886. PMID: 26573060

Clinical prediction guides

Efficacy and safety of autologous tumor-infiltrating lymphocytes in recurrent or refractory ovarian cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Amaria R, Knisely A, Vining D, Kopetz S, Overman MJ, Javle M, Antonoff MB, Tzeng CD, Wolff RA, Pant S, Lito K, Rangel K, Fellman B, Yuan Y, Lu KH, Sakellariou-Thompson D, Haymaker CL, Forget MA, Hwu P, Bernatchez C, Jazaeri AA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-006822. PMID: 38309721Free PMC Article
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA-Associated Pancreatic Cancer in the Clinical and Preclinical Setting.
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Squamousness gain defines pancreatic ductal adenocarcinoma hepatic metastases phenotype, and gemcitabine response.
Fraunhoffer NA, Abuelafia AM, Teyssedou C, Chuluyan E, Bigonnet M, Palazzo L, Gayet O, Nicolle R, Cros J, Iovanna J, Dusetti N
Eur J Cancer 2021 Sep;155:42-53. Epub 2021 Aug 1 doi: 10.1016/j.ejca.2021.06.038. PMID: 34348180
Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome.
Liudahl SM, Betts CB, Sivagnanam S, Morales-Oyarvide V, da Silva A, Yuan C, Hwang S, Grossblatt-Wait A, Leis KR, Larson W, Lavoie MB, Robinson P, Dias Costa A, Väyrynen SA, Clancy TE, Rubinson DA, Link J, Keith D, Horton W, Tempero MA, Vonderheide RH, Jaffee EM, Sheppard B, Goecks J, Sears RC, Park BS, Mori M, Nowak JA, Wolpin BM, Coussens LM
Cancer Discov 2021 Aug;11(8):2014-2031. Epub 2021 Mar 16 doi: 10.1158/2159-8290.CD-20-0841. PMID: 33727309Free PMC Article
Pancreatic tropism of metastatic renal cell carcinoma.
Singla N, Xie Z, Zhang Z, Gao M, Yousuf Q, Onabolu O, McKenzie T, Tcheuyap VT, Ma Y, Choi J, McKay R, Christie A, Torras OR, Bowman IA, Margulis V, Pedrosa I, Przybycin C, Wang T, Kapur P, Rini B, Brugarolas J
JCI Insight 2020 Apr 9;5(7) doi: 10.1172/jci.insight.134564. PMID: 32271170Free PMC Article

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