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Elevated circulating CCL18 level

MedGen UID:
1716604
•Concept ID:
C5397657
•
Finding
Synonym: Increased C-C motif chemokine ligand 18 concentration
 
HPO: HP:0032640

Definition

An increased concentration of C-C motif chemokine ligand 18 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating CCL18 level

Recent clinical studies

Etiology

Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.
Huoman J, Haider S, Simpson A, Murray CS, Custovic A, Jenmalm MC
Pediatr Allergy Immunol 2021 Nov;32(8):1824-1832. Epub 2021 Jun 28 doi: 10.1111/pai.13574. PMID: 34101271Free PMC Article
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
Altered profile of chemokines in fibromyalgia patients.
García JJ, Cidoncha A, Bote ME, Hinchado MD, Ortega E
Ann Clin Biochem 2014 Sep;51(Pt 5):576-81. Epub 2013 Oct 8 doi: 10.1177/0004563213506413. PMID: 24106344
Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection.
Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ
Cytokine 2012 Nov;60(2):328-33. Epub 2012 Aug 3 doi: 10.1016/j.cyto.2012.07.006. PMID: 22863720
Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis.
van Lieshout AW, Fransen J, Flendrie M, Eijsbouts AM, van den Hoogen FH, van Riel PL, Radstake TR
Ann Rheum Dis 2007 Oct;66(10):1334-8. Epub 2007 Mar 9 doi: 10.1136/ard.2006.066084. PMID: 17350968Free PMC Article

Diagnosis

Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.
Huoman J, Haider S, Simpson A, Murray CS, Custovic A, Jenmalm MC
Pediatr Allergy Immunol 2021 Nov;32(8):1824-1832. Epub 2021 Jun 28 doi: 10.1111/pai.13574. PMID: 34101271Free PMC Article
BIOMARKERS OF DISEASE ACTIVITY IN SYSTEMIC SCLEROSIS.
Pawlik KK, Bohdziewicz A, Chrabąszcz M, Stochmal A, Sikora M, Alda-Malicka R, Czuwara J, Rudnicka L
Wiad Lek 2020;73(10):2300-2305. PMID: 33310967
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.
Hamai K, Iwamoto H, Ishikawa N, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N, Kohno N
Dis Markers 2016;2016:4759040. Epub 2016 May 17 doi: 10.1155/2016/4759040. PMID: 27293304Free PMC Article
Altered profile of chemokines in fibromyalgia patients.
García JJ, Cidoncha A, Bote ME, Hinchado MD, Ortega E
Ann Clin Biochem 2014 Sep;51(Pt 5):576-81. Epub 2013 Oct 8 doi: 10.1177/0004563213506413. PMID: 24106344

Therapy

Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis.
Gao X, Jia G, Guttman A, DePianto DJ, Morshead KB, Sun KH, Ramamoorthi N, Vander Heiden JA, Modrusan Z, Wolters PJ, Jahreis A, Arron JR, Khanna D, Ramalingam TR
Cell Rep Med 2020 Nov 17;1(8):100140. doi: 10.1016/j.xcrm.2020.100140. PMID: 33294861Free PMC Article
A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization.
Abrahamsson TR, Sandberg Abelius M, Forsberg A, Björkstén B, Jenmalm MC
Clin Exp Allergy 2011 Dec;41(12):1729-39. Epub 2011 Aug 1 doi: 10.1111/j.1365-2222.2011.03827.x. PMID: 21801246
CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.
Kraaijeveld AO, de Jager SC, de Jager WJ, Prakken BJ, McColl SR, Haspels I, Putter H, van Berkel TJ, Nagelkerken L, Jukema JW, Biessen EA
Circulation 2007 Oct 23;116(17):1931-41. Epub 2007 Oct 1 doi: 10.1161/CIRCULATIONAHA.107.706986. PMID: 17909104
Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis.
van Lieshout AW, Fransen J, Flendrie M, Eijsbouts AM, van den Hoogen FH, van Riel PL, Radstake TR
Ann Rheum Dis 2007 Oct;66(10):1334-8. Epub 2007 Mar 9 doi: 10.1136/ard.2006.066084. PMID: 17350968Free PMC Article

Prognosis

Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.
Huoman J, Haider S, Simpson A, Murray CS, Custovic A, Jenmalm MC
Pediatr Allergy Immunol 2021 Nov;32(8):1824-1832. Epub 2021 Jun 28 doi: 10.1111/pai.13574. PMID: 34101271Free PMC Article
Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis.
Gao X, Jia G, Guttman A, DePianto DJ, Morshead KB, Sun KH, Ramamoorthi N, Vander Heiden JA, Modrusan Z, Wolters PJ, Jahreis A, Arron JR, Khanna D, Ramalingam TR
Cell Rep Med 2020 Nov 17;1(8):100140. doi: 10.1016/j.xcrm.2020.100140. PMID: 33294861Free PMC Article
The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancer.
Huang H, Li J, Hu WJ, Chen C, Luo HQ, Tang XD, Zhou KY, Zhong WT, Li XY
Int J Biol Markers 2019 Jun;34(2):156-162. Epub 2019 May 3 doi: 10.1177/1724600819829758. PMID: 31046524
Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.
Hamai K, Iwamoto H, Ishikawa N, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N, Kohno N
Dis Markers 2016;2016:4759040. Epub 2016 May 17 doi: 10.1155/2016/4759040. PMID: 27293304Free PMC Article
Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection.
Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ
Cytokine 2012 Nov;60(2):328-33. Epub 2012 Aug 3 doi: 10.1016/j.cyto.2012.07.006. PMID: 22863720

Clinical prediction guides

Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.
Huoman J, Haider S, Simpson A, Murray CS, Custovic A, Jenmalm MC
Pediatr Allergy Immunol 2021 Nov;32(8):1824-1832. Epub 2021 Jun 28 doi: 10.1111/pai.13574. PMID: 34101271Free PMC Article
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.
Hamai K, Iwamoto H, Ishikawa N, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N, Kohno N
Dis Markers 2016;2016:4759040. Epub 2016 May 17 doi: 10.1155/2016/4759040. PMID: 27293304Free PMC Article
CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.
Kraaijeveld AO, de Jager SC, de Jager WJ, Prakken BJ, McColl SR, Haspels I, Putter H, van Berkel TJ, Nagelkerken L, Jukema JW, Biessen EA
Circulation 2007 Oct 23;116(17):1931-41. Epub 2007 Oct 1 doi: 10.1161/CIRCULATIONAHA.107.706986. PMID: 17909104
Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis.
van Lieshout AW, Fransen J, Flendrie M, Eijsbouts AM, van den Hoogen FH, van Riel PL, Radstake TR
Ann Rheum Dis 2007 Oct;66(10):1334-8. Epub 2007 Mar 9 doi: 10.1136/ard.2006.066084. PMID: 17350968Free PMC Article

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